u/Cable_tree39

I’m 19 and began noticing some thinning and temple loss in 2024. Over the past 2 years I’ve tried all kinds of doses of oral and topical finasteride 5 separate times, and each time I end up developing intolerable psychological and sexual issues within weeks that get worse and worse the longer I continue taking the drug. I’m now considering topical anti-androgens like KX826 / pyrilutamide.

The problem is that even the low concentration costs around $70 per month, which means over $800 per year for something that may not even work. Would you guys say it’s worth it? Are there any convincing results out there for this solution? I’m also considering adding 2% ketoconazole cream as Ive heard this also has some anti androgenic activity. What’s the best I can do without 5ar inhibitors?

Have any of you been able to use both eyes after the procedure? Did it last?

Any meds or supplements I should get to make it easier? It’s very disorienting and overwhelming

I got the surgery yesterday, but as soon as I took the patch off today to begin the antibiotic drops, I’m kind of freaking out really really bad from just the sheer disorientation. I’m pretty sure I’m seeing in 3d for the first time. Any advice to make it feel less horrible? Please tell me it gets easier soon.

I suspect Ive had gut problems on and off for years that are related to SIBO. I was just prescribed BACTRIM DS to take for an infected ingrown toenail. I know antibiotics are bad for the gut, but I’m seriously feeling sick and feverish and local treatments haven’t worked, so I think I have to take it. Is this antibiotic particularly bad, and are there any foods I should avoid or add to make it less harsh?

Usually costs about $20 more than it does now so if you’ve been thinking of getting it now is a good time, I’m about to try it personally

This could be where Pelage will be presenting the full dataset from phase 2 for PP405

"Following completion of the randomized controlled phase of the study, participants in the placebo group were eligible to enroll in a three-month open-label extension to assess long-term safety, which is now complete. The company plans to share a full dataset from the trial at a future medical meeting in 2026."

I’m 18 and Ive been anxiously waiting almost an entire year for my surgery date. Now I know it will happen in about a month. Whenever I think about it my heart starts beating super fast, my stomach hurts, and I start shaking. I’ve never gone under in my life so I’m mostly scared about the anesthesia. I’m scared I won’t wake up, I’m scared it’ll make me feel super sick, I’m scared of the pain I’ll have to go through. I’m scared I’ll have a fucking panic attack as soon as I enter the building and want to leave at the last second. But I have no choice, I abandoned my life because of this condition, I spent my whole life unable to look in the mirror without crying, excluded wherever I go, treated like garbage. This hell is the reason Ive lived a life of escapism and isolation. I refuse to do it any longer. Did anyone else feel this way before surgery, how did you put your courage for a better life above your fear of suffering? Do they at least give you benzos or something before the surgery?

Each compound works the same way, binding to the androgen receptors of the scalp to kick out testosterone and DHT.

Kx-826 (Pyrilutamide) has the strongest binding affinity, yet somehow shows the weakest results in trials

Ru58841 has weaker binding affinity, yet somehow shows the strongest results in both trials and anecdotal reports, even outperforming finasteride

Cb-03-01 (Clascoterone Breezula) also has a weaker binding affinity, yet shows strong results in trials, but weak results in anecdotal reports

(3 possibilities: The trials are being faked by the manufacturer, the grey market formula is incorrect, or there’s insufficient anecdotal data)

Kx-826 and Cb-03-01 are the most expensive due to their novelty and patent holders, Ru58841 is much cheaper to source

Kx-826 and Cb-03-01 have minimal side effects if absorbed into the bloodstream, while Ru58841 ingestion has been shown to cause heart failure and lung disease. However, ingestion is rare due to the short half life and low concentration.

Which compound is the best for someone who can’t take finasteride?

Ive been reflecting and thinking a lot about my life lately, and I’m starting to think one of the biggest battles man faces is the push and pull between fear and regret. I truly am starting to think that the pain of looking back on our regrets will always outweigh the pain of fear heavily. Are there any philosophers who engaged deeply with this idea?

Has anyone tried ketoconazole solution or cream on the scalp? I know a lot of people try the shampoo, but that only stays on your scalp for 5 minutes. I’m looking for alternatives to 5ar inhibitors.

According to the trials it increases hair density by hundreds of percents compared to placebo

But people who use grey market cb-03-01 claim it’s extremely weak and not even close to ru58841 in effectiveness. The vast majority of anecdotes cant even get maintenance on it.

So is cb-03-01 not the same compound as clascoterone somehow? Or are the clinical trials being faked?

Is it realistic to hope it could be a replacement for 5ar inhibitors?

I’ve tried every dosing protocol you could think of, oral and topical. Every single time I start to get horrific sides after a couple weeks that just get worse and worse as I keep taking it. Should I try dutasteride? Do you guys think we’ll have a better cure against the Norwood reaper in the next few years?

Then why am I losing my hairline so rapidly on it after switching from oral fin? Is this a temporary shed that will grow back, or am I just losing ground by switching to topical?

Let’s say hypothetically someone is born into a Job-like situation where they suffer intensely every day due to health issues, disabilities, and immense loss, and despite spending their days praying to God and worshipping, the suffering never relents even a little. If they asked for forgiveness, would God forgive them for not being able to carry their burdens any longer? Or would he condemn them to eternal hellfire for their weakness and lack of faith?