Y Combinator just released their "Requests for Startups" - what problems and startups they want to fund. i will not promote.
Every cycle or so, YC releases a RFS stating which kinds of problems and/or tech startups they're actively looking for. I find it interesting to glance over the headers of what's considered "attractive" tech verticals for the world's biggest VC.
AI is a given ofc, but this time around they're focusing a bit more on the stuff which makes AI work, as well as stuff around agriculture, space production/mining, hardware/software production, and SaaS Challengers.
This is the Summer 2026 batch. Here are the breakdowns from their site:
AI SOFTWARE
SaaS Challengers - AI has collapsed the cost of building software, which means the moat legacy SaaS relied on is basically gone. Good time to go after the ones that have felt untouchable: ERPs, chip design tools, industrial control systems.
AI-Native Service Companies - Instead of selling software that helps people do a job, just do the job. Accounting, compliance, insurance brokerage, healthcare admin. The services market is much larger than SaaS.
Dynamic Software Interfaces - Coding agents are good enough now that users can reshape software for their own needs. Companies ship the core, users modify the rest.
Software for Agents - AI agents are doing real work but through interfaces built for humans. They need APIs, MCPs, CLIs. Every software category needs a version built with agents in mind first.
AI INFRASTRUCTURE
Company Brain - Critical knowledge is scattered across emails, Slack, tickets, and people's heads. Build a system that pulls it together and makes it usable by AI agents so they can do consistent work without a human filling in the gaps.
The AI Operating System for Companies - Make everything a company produces queryable by an AI layer. Meetings, tickets, customer calls, all of it. The goal is a closed loop where the system flags problems and adjusts rather than waiting for someone to notice weeks later.
Inference Chips for Agent Workflows - GPUs hit around 30-40% utilization on agentic workloads because the work is bursty. There's room for chips designed around how agents actually run, not just prompt-in-response-out.
SCIENCE & MEDICINE
AI-Native Discovery Engines - The scientific loop of hypothesize, experiment, interpret, repeat is slow at every step. The bet is on systems that can run that loop with minimal human input and feed results back in automatically.
AI Personalized Medicine - Genome sequencing is getting cheap fast, new diagnostics are coming to market, and mRNA delivery is maturing. The opportunity is connecting all that personal health data to treatments actually tailored to the individual.
DEFENSE & HARDWARE
Counter-Swarm Defense - A Patriot missile costs $3M, an FPV drone costs $500. Swarms of cheap autonomous drones are a real threat and current systems weren't built for them. Looking for interceptors, sensor fusion software, or non-kinetic countermeasures.
Hardware Supply Chain - In Shenzhen you can go from design to a physical part in a day. In the US that takes weeks. Looking for anything that meaningfully closes that gap.
Supply Chain 2.0 for Semiconductors - A single advanced chip crosses a dozen countries and takes five months to build, mostly tracked with spreadsheets. Real-time allocation tracking, risk monitoring, and export compliance tooling barely exist yet.
SPACE
Electronics in Space - Reusable rockets are making it cheaper to put things in orbit and demand for compute in space is about to grow. Specifically interested in inference chips built around the constraints of space: weight, heat, radiation.
Industrial Capabilities in Space - Extracting raw materials from lunar regolith and 3D printing structures from it on the moon. Some of this is more practical in low gravity than on Earth.
AGRICULTURE
AI for Low-Pesticide Agriculture - Farmers are stuck spraying more chemicals for diminishing returns as pests adapt. AI vision and precision robotics now make it possible to treat individual plants, and bio-based alternatives like microbes and RNA solutions are catching up to replace whole classes of synthetic chemicals.
ENTERPRISE
Startups That Want to Sell to Huge Companies - It used to be nearly impossible for an early-stage startup to land a Fortune 100 deal. That's changing. Enterprise buyers are actively looking, small teams can ship faster than ever, and YC has seen companies land multimillion-dollar pilots within their first year.