Has anyone had their cycle regulate on a GLP-1 at first, then become irregular again around the 6-month mark?
I have PCOS and noticed that after starting a GLP-1, my cycle became much more regular for roughly the first 6 months while I stayed on the starting dose. Like my cycle was exactly 28 days long for about the first 6 months on a starting dose of tirzepatide.
Now, around the 7 & 8 month mark, my last couple of cycles have started becoming irregular again, even though I’m still taking the medication.
I’m curious whether anyone else with PCOS has experienced something similar. If so, did increasing your GLP-1 dose help regulate your cycle again?
I’d also love to understand why this might happen. Is it possible that the starting dose was initially helping enough with insulin resistance/metabolic issues to regulate ovulation, but over time that effect became less pronounced? Or could there be another reason cycles become irregular again despite initially improving?
Obviously I’ll be discussing it with my doctor, but I’d really love to hear other people’s experiences.