u/JoshK92

5-MAPB/Adderall cross tolerance?

Hello, soon I will be trying 5mapb for the first time (75mg Xum Plur tabs). I've been scouring reddit and google for information regarding cross tolerance/interactions/potential risks between 5mapb and Adderall, but haven't found anything that seemed conclusive or specific enough for me to make any determinations.

I'm prescribed 10mg XR & 10mg IR of Adderall per day for inattentive ADHD, though I almost always take one or the other per day instead of both.

I do not plan on taking any Adderall on the day I try the Plur tabs, I want to evaluate them completely on their own. I'm curious about their interactions for 2 reasons:

1- I'm actually hoping that there is a bit of cross tolerance to minimize the possibility or severity of negative side effects on the 5mapb come up. (I seem to be prone to anxiety and rough come ups)

2- I'd be lying if I said I wasn't curious about experimenting with them together to see how the experience is effected, assuming the trial of 5mapb goes well and I decide to try it again in the future.

From my layman's perspective, it seems fair to reason that since MDMA and amphetamines can be mixed reasonably safely (in appropriate doses) then 5mapb and Adderall would share similar interactions and safety guidelines?

To be clear: I will absolutely not be blindly or recklessly experimenting; for all I know, after trying 5mapb on it's own, I may decide it's not for me and never even try it again. I'm simply thinking out loud and seeking more informed input.

With the main point of this post out of the way, I'll ramble about my background if anyone feels like reading it lol - I'm 34 years old, 6 feet tall, 170lbs. In my late teens I used DXM pretty regularly (average 3 times per month, 300mg to 600mg per dose, with occasional higher doses). I was only able to do that for about a year and half before the experience lost it's magic, and my body seemingly started to reject the substance. In the early days, I experienced absolutely zero negative side effects - I was light as feather on the come up. Towards the end, I grew progressively more heavy and was experiencing diminished returns on the experience itself. I took this as my cue to move on from DXM. To this day, I avoid medications containing DXM because I still feel sick just thinking about it.

After DXM, in my early 20s I used LSD (my favorite) several times, MDMA a handful of times, and mushrooms a handful of times. I didn't have any negative experiences with any of these substances. But by my late 20s, with age, less free time, more mental and emotional baggage, I just naturally grew apart from the desire (and access) to use psychedelics, or even smoke weed.

Now in my 30's, I'm curious about exploring altered states of consciousness again. I've used Road Trip gummies a handful of times at low to moderate doses with no negative effects aside from light anxiety on the come up. I do experience severe anxiety, nausea, and vomiting from edible THC products though. So despite my reemerging curiosity, I'm still a bit hesitant to try new things.

The handful of times I tried MDMA, it was hands down the most powerful anti-anxiety I've ever experienced. I'm hoping 5mapb will be as gentle and welcoming as those experiences. In the event I'm one of the people who does experience the rough come up, it definitely won't be my first rodeo lol - I know to remain calm and not try to fight the ocean. With continued research and careful planning, hopefully I can avoid that altogether though, as it is a major road block which deters me from seeking out new psychedelic experiences.

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u/JoshK92 — 4 hours ago