u/Key_Advance2551

I converse many hours with AI (Gemini) about this topic, using my biology background.

First, many skin proteins and enzymes contain sulfur via their amino acids (Met and Cys), which could potentially be broken down into an onion-like smell molecule. Onion's molecule itself causes mucus production by generating small amounts of acid upon contact with skin. A similar molecule might do the same.

Second, there is already research ongoing to see what skin bacteria enzymes may cause such odors. Per Gemini: https://www.hyms.ac.uk/research/research-centres-and-groups/skin-research-centre/projects/the-molecular-basis-of-thioalcohol-production-in-human-body-odour

I would be very optimistic, because it seems an enzyme inhibitor seems to be in the works by Unilever, a major personal care company.

Third, as a response to my suggestion to use ozone (which I experimented with years prior, see my prior posts), the AI responded it was a possible solution to sulfur-based odors. To that I suggested an ozone chamber to remove such smells from clothing, and the AI found me these:

https://www.reddit.com/r/hockeygoalies/comments/ckpxtw/i_wanted_to_share_my_diy_ozone_closet_all/

https://deerhunterforum.com/threads/ozone-closets.3350/

Animals are generally more sensitive to odors. If hunters are using ozone chambers to remove clothing smells already, perhaps there is a possible clothing component to PATM as well.

Originally wrote out because I was pissed off PATM was preventing me from attending NYCC. Lol. Hopefully we get cured soon.

Bacteria testing based on stool is widespread, but unreliable. There is little known about the gut microbiome and how each bacterial species behaves inside it. It is just now being discovered.

Instead, a more concrete methodology would rely on established fecal tests for chymotrypsin, trypsin, and elastase (all used to break down protein) to detect any odor causing enzymes in the stool.

I have not looked into it yet, but the enzymes would be the ones related to odor such as methane-producing, sulfur-compound producing, toluene-producing, etc. The gas made in the gut should be a gas that somehow causes constipation for the host and gets across the gut into the blood.

It seems the established methods use antibodies, but a baseline would need to be measured from "normal" people to see how much of a particular enzyme they have, to see what is considered "normal." This could take decades, but its worth studying.

As for methane, which is shown to slow down the gut (causing constipation), a substance of note is bromoform, used in the cattle industry to prevent cow methane. It is toxic to humans, but I am sure a suitable dose or delivery method (perhaps directly to the colon via rectum) will come soon. Or other substances exist to prevent methane in the human gut. Ask AI for more.

Further, a SIBO test might not detect this mechanism. SIBO relies on the methane gases climbing up through the stomach. In this case, methane is contained in the colon, but the secondary effect being bodily toxins unable to leave and hence being emitted from us due to constipation preventing toxins from leaving quickly. This is compounded by most SIBO tests requiring you to fast beforehand, preventing colonic effects from being shown.

The Sekine study is famous for establishing the baseline of PATM relating to toluene, hexene, etc. However, with those results alone, and the data that is all over the place, its hard to make a decisive conclusion.

A blood test confirming the same chemicals can be detected in the subject's blood would show irrefutable proof of PATM having its chemical emissions basis on some liver or gut issue.

Yet despite this, no such research has been done. The methods to detect substances from blood can follow Lawrence Livermore National Laboratories' protocol regarding their detection of DMSO-derivatives from the body of Gloria Ramirez.

If anyone knows why Sekine didn't test the subject's blood, please let me know.

I believe PATM is potentially related to the skin microbiome.

If so, there is something inside the blood, which then gets excreted via the sweat glands, to be broken down into a toxic gas or odorant.

Rather than using antibiotics (oral typically gets out to the skin until the liver adapts), I propose making a compound deodorant which inhibits skin microbiome enzymes one by one.

By repeated experiments, it may be possible to find the inhibitor that works.

Has anyone tried it?

Is supposed to prevent gut microbiome bacteria from de-conjugating waste in body, where de-conjugation leads to re-entry of waste to liver and blood.

Seems to work in other Reddit threads for mold exposure and estrogen removal.

Beware of the chylomicron and other lipophilic substance transporters

PATM is likely caused by a lipophilic molecule

Cocktail method used to treat Hansen's and AIDS

Cocktail deodarant may help if skin microbiome issue

If antibiotic used need to be used in cocktail with other antibiotics or else bacteria adapts

Antibiotic oral "cure" can also be skin effect if antibiotic can exit to skin (certain kinds can)

Hence oral antibiotic alone cannot prove if skin or gut issue

Key is to use many compounds at once so bacteria cannot adapt

Enterohepatic Circulation, look it up

Liver failure, bile salts, lipophilic xenobiotics. There does exist a pharmaceutical to help with this

First noticed when saw instant ramen (spicy flavor) increase rxns

Will test one day. For now will stick it out. Best of luck all