The reverse seems possible but the permanency not, repeated diminishing of positives of things that once worked
Some thoughts on my post finasteride symptoms, long story, multi year... i think 4 years now... may this experience serve someone:
Still have PFS, but not on it's peak.
PEAK: Peak is literally unlivable, I don't think a single human on earth can handle it for years (lasted about 3 months): extreme low energy, extreme brain fog, couldn't even do programming tasks at the time (desk job), strong suicidal thoughts, bad erection quality (tops at 70% and goes away fast without manual stimulation), penis numbness, peeing is slow no potency, a feeling of being underwater, a feeling of your body being delayed, no internal dialog, no amount of rest recovers you even 12+h of sleep, no food taste good, peeing doesnt feel satisfying or the feel of blader emptiness goes away, no mind muscle connection in the gym, inhability to enojoy things you enjoyed before like videogames, movies, food. It feels like well being is being capped while suffering is bottomless. Physical changes on the penis for worse, like going from a 20yr old to a 55yr old in weeks, penis starts bending in ways in never bent before, feels weak, stretches out if pulled, balls are smaller like almost there is nothing there just the sack, everything that is quick and "humph" like is a chore to do, like punching in boxing or reacting rapidly in a videogame... feels of separation between you and your body like its a shell, its delayed and you never connect directly with anything, there is "space" between you and things. less cum load volume, cum is different look-wise and consistency wise, doesnt shoot as far...
During this peak, and before any physical changes (like penis physical changes) i actually fully cured myself for a single day. I took P5P (vitamin b6), about 50mg. Literally in about 3h or so i was fully cured. And i mean fully, and to a point that actually surpassed my normal state before PFS state. If you game a pill right now that makes me feel that way, it worked all the time and i have lifetime supply, i would literally sell my house and everything i own for it, its that good, i rather live in the streets with that feeling, i felt like i could do anything, any mental task or even a backflip, total control o the mind and body, was crazy.
At this cure moment: dick was fuller than before even before FPS, got erect fully with no manual stimulation, just visually and not even strong visual, like i could see someone walking hot in the street and get fully erect, mentally was better than ever, no brain fog, actually felt smarter, feel so much stronger and muscle connection wise, that in the gym i broke bench records by 4 reps from one week to another... this is literally unthinkable to accomplish as ive been for years going to the gym, thats like 6 months of progress in a day.
At this point i thought i was done! Lucky me... but no... and things went worse from here. So it was PEAK suffering -> cured by P5P -> back to PEAK (now with physical changes in the penis for the worse, the 20yr old dick to a 55yr old one).
I also made the mistake of taking P5P every single day, this led me to develop neuropathy, which to this day never went away, although symptoms improved. Strengely what cured me of this is to take more P5P... what i did is stop for months, then condition improved but not fully, still felt numbnes, tingling, loss of control of left hand... then after months of nothing took one p5p pill and it immediatly got better. it was at a local maximum of improvement and taking it again improved it further.
it also improved PFS by not as the first time, less. and this is a patter that repeats itself with other things that helped. They help at the beggining, then less, then less, and then do nothing or only negatives.
P5P: Literal cure the first time. Then mild improvements. Then nothing. Then only negative effects. Now it only helps it taken about once every few months 50mg, and the improvements are very mild.
Enclomophine: This recovered by balls to actuall have some size. Similar pattern. First week nothing, second week felt amazing, could appreciate things like games, movies, food, even just standing felt amazing, inner dialog came back forever, when taking enclomophine my balls where massive in response for a few hours. Then week 3 balls no longer responded... now after years, even after months of not taking it, if i take it it does nothing, only negatives effects: blurry vision, sleepiness, balls dont change.
BUT! Enclomophine is what permanently cured me from PEAK suffering. Now it's just more standard livable post finasteride. Still shit, but this can be handled with.
If now I'm at MIDDLE PFS lets call it, now thing barely move the needs... even if I take enclomophoine, p5p, kisspeptin... i even took steroids like dianabol (this did nothing only make me slightly stronger, but no mind muscle connection).
Now at middle i don't have the nightmare phsicologial terror. My current syntoms are: dick goes to about 90%, cum is lower than pre PFS, rare times goes to 100% but goes away fast always. mild brain fog, low level sugar-like syntoms of feeling tired and not connecting with the muscle, specially at forearms. too much sleepiness. in general i feel like im 70% me, but have the capacity to be 100% but just cant unlock it no matter what i do and i alway have this feel that something is wrong.
So what im seeing is, recovery is possible... except for physical stuff, i dont think my dick can go back as before, it requires a miracly... it just feels like its someone else dick, while the workings of it can improve, as ive improved it multiple times... just to go back to 80%. but at the phisical level seems like permanent damage.
But while recovery is possible, it works in strange ways where a thing that worked before no longer works. Again this happened multiple times: with php, enclomophine, tribulus with protodioscin... first time amazing, then mild, then nothing, and then just negatives...
So my recomendation to those who never tried p5p or enclomophine is the following:
Use it once, literally once, if it improves you, then stop. See how long can you keep up without taking it back, and if you are recovered to 70 - 80% then leave it there never take those again unless you drop to shitty levels. Otherwise it seems it will stop working sadly.
One thing i point out it, i never felt loss of libido. libido was always high, specially mentally, just dick didnt respond, which created frustration, but libido was there and was high all the time.
Regarding blood, by test is low, below normal range, i actually got it higher at some point, but felt worse. i also did panel for dht and estradiol. I can conclude that the only thing that helped me feel better is having less DHT and more estrdiol for some reason. Everytime the blood showed this, i felt better.
At some point i had normal range dht and low test and estradiol, felt like shit. then had more test, more estradiol and lower dht and that time felt better.
This is further corraborated by taking dht pills like proviron, literally made me feel worse, specially on the dick that almost dissapeared at this poin, was very weak and small looking unless stimulated. I also took estradiol directly and it either did absolutely nothing or made me feel better. So i think this is conclusive for my case at least. And i took decent estradiol doses like 25mg a few days and it either did nothing or made me feel better, dick felt better as well, more full, providon did the oppositve.
One theory could be that before PFS you had good dht, test and estradiol balance, then once you took finasteride, the body bad less dht, now with less dht it tries to compensate by lowering estradiol so it goes back into range, but now when you stop finasteride, dht surges back up, and you are again out of balance, but now the body cannot balance the rest and you feel like shit.
Again, at blood panels higher test didnt made me feel better, it was irrelevant, as currently is lower than at peak but i feel better. more dht always meant feeling worse, and higher estradiol made me feel better.
Currently im stuck at recovery limbo, i dont have hopes to ever come back to pre PFS and even less to the P5P type of extreme cure. Today the only thing that works to a small degree:
P5P still works, but only about once monthly or once every two months, but the risks or neuropathy are there even at that low dose and frequency. So i protect myself as much as possible by taking, at the same, once single dose only once a month:
P5P 25mb, b2 100mb, other b bitamins like b1, b9. zinc and magnesium (seems zinc, magnesium and b2 help with p5p transport and thus avoiding negatives), estradiol as esterone pill, kisspeptin 10 intra-nassaly, cistanche. i take kisspeptin to avoid potential supression due to esterone, but even taking esterone by itself i never felt surpress.
I take this massive combo once a month and it feel like it improves a little and the improvement last multiple weeks at least. but its very mild, and if i feel ok i dont take it as the risks are not worth it.
But if you are at a point where you didnt try p5p, or ecnlomophine or kisspeptin and you do, and it works, i suggest to stop. the positive may be permanent to some degree, and taking more has very high risk of stopping working.
Another theory i have is some people are born with PFS like syntoms... like by default they are like that. Low energy people, or ones that dont erect just by looking at some hot chick... like before PFS dick problems were unthinkable, there was no way not to get hard, and stay hard, it doesnt even go away, waking up with a boner every single day... but some people are not like that, also are somewhat slow in reaction times, very sleepy by default...etc So i feel like some people unafected by finasteride are people that by defaul are like that already, at least some portion of people. another piece of evidence is adult content... some guys dicks... bro your shit is not supposed to look or bend like that. and if fully erect it points upwards not forward. before i couldnt even understand what was going on there... now sadly i do.
I would classify people as: they are post finasteride like before, so unafected by the drug. Or others that are affected, but the body can go back to basline after stopping. For example one body could develop gyno from finasteride, because estradiol production is manteined, while other dont develop gyno, because their body mehanism is to lower estradiol production as response.
I feel like there should be more research on this, not only for people with PFS, but for all people in general, if a true cure is found, i feel like it could improve the lives of the general population as well, like maximizing who you are as a person. It feel like if you can go one way to the depths of hell with this, you could go in the opposite direction as well and improve your well being by a lot even if today you feel normal.