People who has this for more than 6 years, how has it been changing for you ? Is it getting worse ? Better? No change, I’m a long time sufferer and I feel like it’s changing, like mostly getting worse I guess

I wanted to write this because when my symptoms first started, one of the worst things I did was read endless stories online that made the situation sound completely hopeless and permanent.

I understand why people who are suffering write those posts. When you’re in the middle of it, it genuinely feels like something fundamental inside you has disappeared. But people who improve often stop visiting these communities. Because of that, I think recovery stories are probably underrepresented.

So this is mine:

When I stopped finasteride, I fell into a state that is difficult to describe unless you have experienced it yourself. My libido was pretty much completely gone, I felt emotionally blunted, and there was this profound disconnect between what I knew I should be feeling and what I was actually able to feel. I could still understand things intellectually, but the emotional response behind them was missing. It felt like I was watching my old self from a distance.
The first thing I did was exactly what I would now tell people not to do: I panicked and tried to force myself back to normal.
I read endless PFS stories and protocols online and started experimenting with anything that sounded remotely promising. Mucuna pruriens, ashwagandha, saffron, different supplements, different combinations. I was constantly searching for the one thing that would switch my old brain and feelings back on.
And some of those things did something.
That was almost what made it worse.
Sometimes I would get a tiny spark. A little more libido, a bit more emotional response, a moment where I thought: there it is, I’m coming back.
But it never really felt like me.
It felt artificial. Like I had pushed my system hard enough to create a faint imitation of something I used to experience naturally. And as soon as I stopped taking whatever I was experimenting with, I would fall back into the same emptiness. And If i didn‘t stop myself the tiny spark i was feeling disappeared by itself.
So I got stuck in this cycle of trying something, noticing a tiny change, becoming hopeful, monitoring myself constantly, losing the effect, crashing again and then searching for the next thing.
Looking back, that desperate need to “fix” myself was one of the most exhausting parts of the whole experience.
The thing I eventually had to accept was that there was no switch I could flip.
Recovery, at least for me, was mostly about time.
And I know how frustrating that sounds when you are in the middle of it. I hated the idea of simply waiting. I wanted something active to do. I wanted a protocol, a substance, a mechanism I could control.
But my body did not recover in a straight line and it did not recover because of one intervention.
It came in waves.
There were periods where I clearly felt better, followed by periods where I felt like I had lost all of that progress again. Sometimes physical or sexual sensations would return before the emotional part did. Sometimes I would notice a little more attraction, more motivation or more pleasure, only for it to fade again.
If I judged my recovery day by day, it looked completely chaotic.
If I looked at it over months, the direction was much clearer.
The waves kept going up and down, but the overall baseline was slowly moving upward.
One part of my story that I also don’t want to leave out is cannabis.
I had roughly three periods during this whole process where I used cannabis relatively regularly. I’m not recommending it, and I absolutely do not think people should read this as “cannabis treats PFS.”
For me, it did something much more limited.
During those phases, it sometimes gave me a very muted glimpse of myself again. It did not restore my libido or reactivate my emotional system in any lasting way. It was more like, for a moment, I could recognize parts of my personality and inner world again.
It still felt dampened and incomplete, but that mattered psychologically.
After the third of those phases, I was finally in a state where I could start rebuilding habits that I simply had not been able to maintain while I was at my lowest.
And that was the point where things started changing more meaningfully.
Not because cannabis “fixed” anything, but because I finally started changing the way I lived because after stopping cannabis consumption(after a time where i smoked every day for like 1-2 Months straight) I had like a „small window“ for 2-3 werks that allowed me to „jump on the train“:
I began training consistently again. I returned to strength training and started pushing my body physically instead of living almost entirely inside my own head and constantly checking whether I felt normal yet.
At the same time, I changed my diet significantly.
I started eating much more fruit and vegetables, paying more attention to whole foods, protein, healthy fats and micronutrients, and generally asking myself whether I was actually giving my body the basic things it needs to function well and to repair itself.
That shift became very important to me.
I stopped asking, what substance can repair me?
Instead I started asking, what conditions am I giving my body to repair itself?
I don’t want to overstate this. I am not claiming that fruit, vegetables and the gym are a scientifically proven cure for PFS. I can’t tell anyone exactly why I improved, and I can’t separate one factor perfectly from another.
What I can say is that the combination of time, a much healthier lifestyle, physical activity and eventually trusting my body instead of constantly interfering with it was what coincided with my most meaningful recovery.
And that recovery was incredibly gradual.
It wasn’t one morning where I woke up and everything was back.
At first, certain sensations returned.
Then there were more moments of spontaneous attraction.
Then emotions started carrying more weight again.
Then libido became more consistent.
And even now, I still feel like my body and mind are reconnecting.
That is probably one of the strangest parts of this whole experience.
For a long time, the physical side and the emotional side felt separated. A bodily response could happen without the corresponding emotional feeling fully being there. Even as physical sensations and nerve responses returned, my mind did not immediately know how to connect to them in the way it once had.
That connection is still continuing to rebuild.
But the difference compared with where I started is enormous.
At this point, roughly 1 year and 8–9 months after stopping finasteride, my libido has returned to the point where it can sometimes actually feel too strong.
That is surreal to write, because there was a time when I genuinely believed I might never feel normal sexual desire again.
My emotional life has also come back in a way I honestly could not imagine during the worst period.
And the biggest difference is this:
The feelings no longer feel artificially induced.
I don’t need to take something and wait for a tiny spark.
They arise on their own.
They feel like mine.
That is what I wish I had understood at the beginning.
I spent so much time trying to drag my old self back by force, when what I ultimately needed was to stop constantly manipulating my system, give it stability, give it the basics it needed and allow recovery to happen on its own timeline.
That does not mean doing nothing.
For me, “giving it time” did not mean lying in bed and hoping for the best.
It meant rebuilding my life around things that were actually good for me: exercise, proper food, routine, sleep, movement, structure and gradually participating in life again even when I did not yet feel completely like myself.
And it meant accepting that a bad week did not erase months of progress.
I also want to say something about PFS communities, because I think they can distort your perception very badly when you are newly affected.
The suffering people describe there is real. I don’t want to minimize that at all.
But there is also an obvious selection effect.
When someone is terrified, numb and constantly thinking about PFS, they spend hours reading forums.
When someone slowly gets better, they start doing other things again.
They go to work. They study. They train. They date. They see friends. They think about ordinary life instead of spending every evening analyzing symptoms.
And many of them never come back to write a recovery post.
That can make these communities look much more hopeless than reality necessarily is.
I cannot promise anyone that their recovery will look like mine.
I cannot tell anyone how long it will take.
I cannot tell you that a certain diet, supplement or exercise routine will cure you.
But I can tell you this:
For a long time, I genuinely thought I had lost a fundamental part of myself.
I had moments where the only thing I could produce were these weak, artificial glimpses of my previous emotions.
I thought that might be all I would ever get.
It wasn’t.
My recovery was slow, uneven, frustrating and full of setbacks.
But when I look at the overall trajectory, it has been very real.
So if you are currently in the stage where you are trying ten different supplements, checking your libido twenty times a day and interpreting every bad day as proof that you are permanently broken, I would at least consider doing the opposite.
Stop chasing every tiny biochemical lever you read about online.
Get sensible medical testing if you need it.
Then give your body consistency.
Eat well.
Move.
Train if you can.
Sleep.
Build routines.
Give yourself time.
And judge your progress over months, not hours.

am I the only so bad that I can’t tolerate any meds or supplements.

Anyone else having even more trouble getting a hard-on when standing. Weird shit, I have to lie down beat meat and then on a good day I get 100% erect. Standing gives me 60% size max.

I have all the worst side effects. Erectile dysfunction, low libido, brain fog, slowed mental processing, word finding difficulties. I likely have some of the ones regarding depression too, but I can't even tell at this point. I used to be a human being. I used to be human. I used to be the quick witted one who made everyone laugh with jokes. Always knew the right thing to say to comfort my friend's. Was very into writing and wordplay. It takes me multiple seconds to remember basic words, and my thinking is slowed. I'm a husk of who I used to be. Mentally slow. Mentally fucking slow. I didnt want to go bald. I didnt know about any of this, and now my life is ruined. There's nothing left for me in this life. How am I supposed to live as half a man? I've lost everything that makes up myself. I'm 23. Stopped and started it when I was 21. Two years later, and at the point in which my life should be getting started, it's ended. I need a professional cure. I need anything. I know there isn't, but I need it. I can't do this. I can't go on.

So yesterday I took my first injection of allopregnanolone caproate (at 10mg). And yesterday I was very, very depressed because of PFS obviously but also because of some other things happening in my life (and probably because I unfortunately had to take quetiapine to sleep). And this was actually good because then I could see if the ALLO would indeed work or not.

Within 20-30 minutes after the shot, I started noticing the effects kicking in. And later on I was no longer depressed, my drive for life had comeback, my anxiety was nearly zero. My TMJ disfunction stopped. Everything was better and I was feeling like my older self essentially.

I took the shot during the day because the person who told me about this said that he talked with the sellers and they told him to take at morning time, but my next shot will be at the beginning of the night (for the insomnia), cause I experienced drowsiness and was sleepy until 5 hours after the shot at 2:30pm.

I now need to finish the vial and see how I’ll feel, I think I’ll keep taking 10mg so it can last longer. I’ll be buying more for sure and I’m trying to get access to Zuranolone via importation. I’m also buying Etifoxine (oral neurosteroids booster).

All I can say is that allopregnanolone is a miracle molecule, and to think we blocked this is insane (finasteride is pure poison). I say this because if you research, you’ll see that not only ALLO acts on GABA-A to promote its effects, but it also upregulates and modulates it. This is the opposite of what benzos do, benzos act on GABA-A but downregulate it over time.

This was just the first day and I need to finish the vial to see how I’ll feel afterwards. But maybe because we have PFS we need to be taking this for life or at least for a longer time than the 14 days used in depression. But maybe not cause we have reports of recovery with Etifoxine, GHB, and also Ketamine (although this one does not act on neurosteroids).

When it comes to ALLO medications, we just don’t have many reports/experiences because essentially, for some very suspicious reason, no one can get access to it (but get access to poisons like benzos). Brexanolone (the IV one) for example is approved since 2019, but heavily restricted and overpriced; and now the same is happening with zuranolone (very, very cheap in Japan though as I showed in my last post).

Now almost 24 hours later I’m feeling slightly better than before the shot (less depressed), but we know the official treatment consists of 14 days. This caproate ALLO will last less than that at 10mg (in the website it says 5-30mg per week). So that’s the update for now.

Been taking oral finasteride 1mg for past 1.5 months for MPB, although baldness improved but since start of 1 month been experiencing weak erections(like 70% only able to get it up compared to 100% before). Should I stop taking the medication altogether or take it alternate days or keep taking it and ED might get better? Anyone who is experienced can you please comment?

Hey guys, I’m 24yo from the Netherlands
I took 1mg of Finasteride starting on May 1st, 2026, and stopped in June 2026 after taking about 25 pills in total. I quit because of side effects. My erections have completely returned to normal now, and while I still have slightly watery semen, that isn't my main concern right now.
What I’m suffering from the most is intense Depersonalization / Derealization (DP/DR). I feel completely disconnected from reality, dizzy, and I'm honestly terrified.
Here is my timeline:
Initial side effects: About 11 days after stopping in June, I got hit with heavy brain fog. Eventually, that cleared up and I started feeling much better.
The relapse: Last week, the brain fog and severe DP/DR came back full force, and it’s not going away. I feel dizzy and detached from everything around me.
Doctor visits: I went to my family doctor about two months ago, and she just told me to wait two weeks. She eventually referred me to a psychiatrist, but he wasn't helpful at all—he basically just told me to fix my sleep schedule and sent me on my way.
I feel stuck and scared. Is this actual PFS (Post-Finasteride Syndrome), or is my nervous system just completely burnt out from high anxiety and hyper-vigilance? Has anyone else experienced this delayed DP/DR wave after quitting, and how did you get your mind back to baseline?
I'd really appreciate any advice or shared experiences.

I didn't even get it from Fin I got it from Mold/Covid/Gauncaficine. But around the time I got sick I got kicked out of college for some unrelated stupid reason. I got a bunch of money taken from me I also lost all my friends and my gf right before getting sick.

I know its out of the scope of these posts but I can't help but wonder if a real curse was put on me. You can't even begin to explain all the bad things that happened to me in 2021-2022 and they all still linger today I have never been able to move on. When I start to add up all the bad things that happened over the course of months I genuinely can't believe it. Its so bad it almost seems like a comic.

Its as if some demon has done everything in his power to make me kill myself. I felt like during those years the entire energy shifted and I knew I was fucked. Everything I ever tried went wrong in life. Its like I entered a hellish reality everyone also hates me its like they can sense I have a cursed aura and want nothing to do with me.

The only reason I don't kill myself is I received a sign from God to not do it. Even I am not foolish enough to ignore that I know if I ended my life things will get worse.

I’m coming up on 6 years with PFS, and unfortunately my condition seems to be deteriorating rather than improving. I’ve gone from really bad to somehow even worse.

For the first few years, one of the only ways I could get my brain and CNS to calm down was by pushing myself physically. At one point I was lifting 3–5 days a week and running 40–50 miles per week. Exercise was one of the few things that made me feel somewhat normal.

After a few years, I needed knee and hip surgery and went through a long recovery of about a year. Eventually I was able to get back to lifting and running. Through everything PFS had taken from me, I was incredibly grateful that I could still use my body and push myself physically.

For about the past 18 months, though, I’ve been back in the sufferfest. My brain and body feel permanently stuck in fight or flight. Intrusive thoughts, constant hyperarousal, essentially zero stress tolerance. I’ve stopped all supplements, made dietary changes, tried simplifying everything, and nothing has made a meaningful difference.

Last month I hurt my back and then got sick immediately afterward. For a few weeks I could barely get out of bed and did absolutely no exercise. For the first time in months, I could actually feel my nervous system starting to calm down. My mind became clearer. I was able to sit quietly and read several books. I started feeling like I was coming out of this constant fight-or-flight state.

Now my back is better and I’ve started going to the gym again. Almost immediately, I’m back in fight or flight and feeling terrible.

I’ve seen people here talk about exercise intolerance and eventually recovering from it, but I’m wondering if anyone has experienced this developing or worsening years into PFS.

At this point, my stress tolerance is basically nonexistent. I can’t go to a restaurant. Apparently I can’t go to the gym. I even tried learning a new language and had to cancel the lessons because it was too stimulating. It feels like almost any physical or mental stress pushes my nervous system over the edge.

Exercise was the last thing I felt like PFS hadn’t taken from me, which makes this particularly difficult to accept.

Has anyone had a similar progression where exercise initially helped for years, but eventually started making your symptoms significantly worse? Did you have to stop exercising completely for a period of time? And if so, were you eventually able to build your tolerance back up?

I’m trying to understand whether anyone else has gone through this trajectory and come out the other side.

Hi all, just wanna share my issues and would like to hear whether this is something others have experienced as well and how you dealt with it. Ive been doing minoxidil for two years orally and started doing 1,25mg oral finasteride 2 weeks ago. Already after the 2nd night I got hit with major sleep issues. Difficult to fall asleep, waking up during the night and having trouble going back to sleep.

I know sleep issues are common, but most posts I read about this seem to describe a gradual/late problem, whereas mine hit instantly.

Two weeks later (and off finasteride after that 2nd dose) I'm still struggling a lot. I also realize placebo (or rather nocebo) and anxiety can play a part, but damn, it was like turning a switch for me. I'll never do finasteride again, but curious on what to expect going forward.

Thanks for any feedback.

I am proof that even a perfume can cause a breakdown due to its ingredients. I was cognitively fine in recent days, but the reason I got worse was buying and using a perfume, and now I feel a little dizzy and tired, and yesterday my penis was cold, just like it was 6 months ago. This is proof of how bad an illness we have. I pray to God for healing for all of us 🤲🏼

Product contents:

PEPPER,VIOLET,CARDAMOM,LAVENDER,SWEET,APPLE,JASMINE,LILY OF THE VALLEY,AMBERWOOD,TONKA BEAN,CEDARWOOD,VANILLA,MUSK

Some thoughts on my post finasteride symptoms, long story, multi year... i think 4 years now... may this experience serve someone:

Still have PFS, but not on it's peak.

PEAK: Peak is literally unlivable, I don't think a single human on earth can handle it for years (lasted about 3 months): extreme low energy, extreme brain fog, couldn't even do programming tasks at the time (desk job), strong suicidal thoughts, bad erection quality (tops at 70% and goes away fast without manual stimulation), penis numbness, peeing is slow no potency, a feeling of being underwater, a feeling of your body being delayed, no internal dialog, no amount of rest recovers you even 12+h of sleep, no food taste good, peeing doesnt feel satisfying or the feel of blader emptiness goes away, no mind muscle connection in the gym, inhability to enojoy things you enjoyed before like videogames, movies, food. It feels like well being is being capped while suffering is bottomless. Physical changes on the penis for worse, like going from a 20yr old to a 55yr old in weeks, penis starts bending in ways in never bent before, feels weak, stretches out if pulled, balls are smaller like almost there is nothing there just the sack, everything that is quick and "humph" like is a chore to do, like punching in boxing or reacting rapidly in a videogame... feels of separation between you and your body like its a shell, its delayed and you never connect directly with anything, there is "space" between you and things. less cum load volume, cum is different look-wise and consistency wise, doesnt shoot as far...

During this peak, and before any physical changes (like penis physical changes) i actually fully cured myself for a single day. I took P5P (vitamin b6), about 50mg. Literally in about 3h or so i was fully cured. And i mean fully, and to a point that actually surpassed my normal state before PFS state. If you game a pill right now that makes me feel that way, it worked all the time and i have lifetime supply, i would literally sell my house and everything i own for it, its that good, i rather live in the streets with that feeling, i felt like i could do anything, any mental task or even a backflip, total control o the mind and body, was crazy.

At this cure moment: dick was fuller than before even before FPS, got erect fully with no manual stimulation, just visually and not even strong visual, like i could see someone walking hot in the street and get fully erect, mentally was better than ever, no brain fog, actually felt smarter, feel so much stronger and muscle connection wise, that in the gym i broke bench records by 4 reps from one week to another... this is literally unthinkable to accomplish as ive been for years going to the gym, thats like 6 months of progress in a day.

At this point i thought i was done! Lucky me... but no... and things went worse from here. So it was PEAK suffering -> cured by P5P -> back to PEAK (now with physical changes in the penis for the worse, the 20yr old dick to a 55yr old one).

I also made the mistake of taking P5P every single day, this led me to develop neuropathy, which to this day never went away, although symptoms improved. Strengely what cured me of this is to take more P5P... what i did is stop for months, then condition improved but not fully, still felt numbnes, tingling, loss of control of left hand... then after months of nothing took one p5p pill and it immediatly got better. it was at a local maximum of improvement and taking it again improved it further.

it also improved PFS by not as the first time, less. and this is a patter that repeats itself with other things that helped. They help at the beggining, then less, then less, and then do nothing or only negatives.

P5P: Literal cure the first time. Then mild improvements. Then nothing. Then only negative effects. Now it only helps it taken about once every few months 50mg, and the improvements are very mild.

Enclomophine: This recovered by balls to actuall have some size. Similar pattern. First week nothing, second week felt amazing, could appreciate things like games, movies, food, even just standing felt amazing, inner dialog came back forever, when taking enclomophine my balls where massive in response for a few hours. Then week 3 balls no longer responded... now after years, even after months of not taking it, if i take it it does nothing, only negatives effects: blurry vision, sleepiness, balls dont change.

BUT! Enclomophine is what permanently cured me from PEAK suffering. Now it's just more standard livable post finasteride. Still shit, but this can be handled with.

If now I'm at MIDDLE PFS lets call it, now thing barely move the needs... even if I take enclomophoine, p5p, kisspeptin... i even took steroids like dianabol (this did nothing only make me slightly stronger, but no mind muscle connection).

Now at middle i don't have the nightmare phsicologial terror. My current syntoms are: dick goes to about 90%, cum is lower than pre PFS, rare times goes to 100% but goes away fast always. mild brain fog, low level sugar-like syntoms of feeling tired and not connecting with the muscle, specially at forearms. too much sleepiness. in general i feel like im 70% me, but have the capacity to be 100% but just cant unlock it no matter what i do and i alway have this feel that something is wrong.

So what im seeing is, recovery is possible... except for physical stuff, i dont think my dick can go back as before, it requires a miracly... it just feels like its someone else dick, while the workings of it can improve, as ive improved it multiple times... just to go back to 80%. but at the phisical level seems like permanent damage.

But while recovery is possible, it works in strange ways where a thing that worked before no longer works. Again this happened multiple times: with php, enclomophine, tribulus with protodioscin... first time amazing, then mild, then nothing, and then just negatives...

So my recomendation to those who never tried p5p or enclomophine is the following:

Use it once, literally once, if it improves you, then stop. See how long can you keep up without taking it back, and if you are recovered to 70 - 80% then leave it there never take those again unless you drop to shitty levels. Otherwise it seems it will stop working sadly.

One thing i point out it, i never felt loss of libido. libido was always high, specially mentally, just dick didnt respond, which created frustration, but libido was there and was high all the time.

Regarding blood, by test is low, below normal range, i actually got it higher at some point, but felt worse. i also did panel for dht and estradiol. I can conclude that the only thing that helped me feel better is having less DHT and more estrdiol for some reason. Everytime the blood showed this, i felt better.

At some point i had normal range dht and low test and estradiol, felt like shit. then had more test, more estradiol and lower dht and that time felt better.

This is further corraborated by taking dht pills like proviron, literally made me feel worse, specially on the dick that almost dissapeared at this poin, was very weak and small looking unless stimulated. I also took estradiol directly and it either did absolutely nothing or made me feel better. So i think this is conclusive for my case at least. And i took decent estradiol doses like 25mg a few days and it either did nothing or made me feel better, dick felt better as well, more full, providon did the oppositve.

One theory could be that before PFS you had good dht, test and estradiol balance, then once you took finasteride, the body bad less dht, now with less dht it tries to compensate by lowering estradiol so it goes back into range, but now when you stop finasteride, dht surges back up, and you are again out of balance, but now the body cannot balance the rest and you feel like shit.

Again, at blood panels higher test didnt made me feel better, it was irrelevant, as currently is lower than at peak but i feel better. more dht always meant feeling worse, and higher estradiol made me feel better.

Currently im stuck at recovery limbo, i dont have hopes to ever come back to pre PFS and even less to the P5P type of extreme cure. Today the only thing that works to a small degree:

P5P still works, but only about once monthly or once every two months, but the risks or neuropathy are there even at that low dose and frequency. So i protect myself as much as possible by taking, at the same, once single dose only once a month:

P5P 25mb, b2 100mb, other b bitamins like b1, b9. zinc and magnesium (seems zinc, magnesium and b2 help with p5p transport and thus avoiding negatives), estradiol as esterone pill, kisspeptin 10 intra-nassaly, cistanche. i take kisspeptin to avoid potential supression due to esterone, but even taking esterone by itself i never felt surpress.

I take this massive combo once a month and it feel like it improves a little and the improvement last multiple weeks at least. but its very mild, and if i feel ok i dont take it as the risks are not worth it.

But if you are at a point where you didnt try p5p, or ecnlomophine or kisspeptin and you do, and it works, i suggest to stop. the positive may be permanent to some degree, and taking more has very high risk of stopping working.

Another theory i have is some people are born with PFS like syntoms... like by default they are like that. Low energy people, or ones that dont erect just by looking at some hot chick... like before PFS dick problems were unthinkable, there was no way not to get hard, and stay hard, it doesnt even go away, waking up with a boner every single day... but some people are not like that, also are somewhat slow in reaction times, very sleepy by default...etc So i feel like some people unafected by finasteride are people that by defaul are like that already, at least some portion of people. another piece of evidence is adult content... some guys dicks... bro your shit is not supposed to look or bend like that. and if fully erect it points upwards not forward. before i couldnt even understand what was going on there... now sadly i do.

I would classify people as: they are post finasteride like before, so unafected by the drug. Or others that are affected, but the body can go back to basline after stopping. For example one body could develop gyno from finasteride, because estradiol production is manteined, while other dont develop gyno, because their body mehanism is to lower estradiol production as response.

I feel like there should be more research on this, not only for people with PFS, but for all people in general, if a true cure is found, i feel like it could improve the lives of the general population as well, like maximizing who you are as a person. It feel like if you can go one way to the depths of hell with this, you could go in the opposite direction as well and improve your well being by a lot even if today you feel normal.

Both Google and Grok inform this. I just don’t understand how cheap medications can be so expensive in the US (I know health insurance covers it most of the time, but still atrocious, because of the off-label needs).

Google:

“In Japan, the official National Health Insurance (NHI) drug reimbursement price for Shionogi's ZURZUVAE Capsules 30 mg (generic name: zuranolone) is ¥646.80 per 30 mg capsule.

Treatment Cost Breakdown
Per Capsule: ¥646.80 (NHI price)

Standard Dosage: 1 capsule (30 mg) once daily after dinner for 14 days”

Grok:

“In Japan, the National Health Insurance (NHI) price (薬価) for zuranolone (ズラノロン) is 646.80 yen per 30 mg capsule (brand name: ザズベイカプセル30mg / Zazubei Capsule 30 mg, marketed by Shionogi).

It was approved in December 2025 for depression/depressive states (**うつ**病・うつ************状態) and listed on the NHI drug price list on March 18, 2026.

This is substantially lower than the U.S. list price for a 14-day course of Zurzuvae (around $15,900).”

We need to fight for this. I’ll try to import the medication to my country from Japan.

For those who don’t know, Zuranolone (allopregnanolone) upregulates, restores and modulates the GABA-A receptor. That’s why the treatment is only for 14 days (very similar to the treatment of depression using ketamine)!

I posted this over in r/tressless and it instantly got removed.

The male body needs DHT to function normally. Unfortunately the current treatments we have for male hair loss aren’t very good with the only drug that tackles the root cause of baldness (finasteride) reduces DHT levels systemically throughout the body instead of only in the scalp. Finasteride is not a DHT blocker, it is an enzyme blocker. The enzyme 5 alpha reductase in the body also produces essential neurosteroids in the brain which would explain the brain fog and depression because this mechanism is blocked when taking the drug.

Certain compounds are in development which use a more targeted approach but as of now for the last 30 years finasteride has been the only effective treatment for hair loss. If a man is still relatively young like 20s and 30s, it’s not worth it to take this drug which affects the entire body instead of just the DHT in the scalp for a cosmetic condition.

The worst part about it is pharma reps at Merck knew this, they aren’t stupid they knew the drug affects the entire body yet they still market it as safe and that side effects are rare. Keep in mind that it was not developed for hair loss. The effects on hair are an unintended side effect. It was originally created for 50-60 year old men with enlarged prostates.

I started taking finasteride about two weeks ago. Recently, I’ve started experiencing pain and discomfort throughout both of my arms.

It seems to get significantly worse when I do anything physically demanding. Sometimes the pain gets so bad afterward that I can barely use my arms.

Has anyone experienced anything similar while taking finasteride? I’d really appreciate hearing from anyone who has experienced similar symptoms.

I've been affected relatively recently with fluctuations in anxiety and insomnia in particular... Currently anxiety spiked again and made me feel so restless I might as well go for a run at 10:54.

I don't want this to be permanent so bad - that's what's freaking me out - doubt on if this state is permanent. I just want to rest, go to sleep normally and be anxiety free, or at least be 90% free of this. Anything supportive is greatly appreciated, if you have had a similar experience and recovered, that too

I’ve heard that a PFS research paper may be submitted to a scientific journal by the end of this year.

What I’m trying to understand is what usually happens after submission and how long the whole process can realistically take.

For example, if a manuscript is submitted in December:

• How long does the first peer-review round usually take?
• How many rounds of revisions are common?
• How long can it take from submission to acceptance?
• And after acceptance, how long until the paper is actually available online?

I know this varies a lot between journals and studies, but I’m mainly looking for a rough realistic timeline.

For example, would something like this be plausible?

Submission → first reviews: 1–3 months → revisions: 1–3 months → acceptance/publication: another 1–3 months

So are we usually talking about several months, around a year, or potentially much longer?

If anyone here has experience with academic publishing or knows how previous PFS papers moved through peer review, I’d really appreciate your insight.