u/yshcrp

I’m gonna be trying this one too as there are reports of recovery with it. This is not medical advice nor quick fix. It’s just for informational purposes. I just recently came across this substance.

Etifoxine stimulates the biosynthesis and levels of several key neurosteroids, most notably allopregnanolone, which heavily mediates its calming and anxiolytic effects. It also boosts levels of progesterone, pregnenolone, 17-hydroxypregnenolone, and DHEA.

It has been approved and marketed in approximately 53 countries worldwide. It was originally developed and is most widely used in France.

To avoid censorship when it comes to this topic, I decided to start a new sub called PFS_Protocols. You are all very welcome!

https://www.reddit.com/r/PFS\_Protocols/s/65madaYMoo

So yesterday I took my first injection of allopregnanolone caproate (at 10mg). And yesterday I was very, very depressed because of PFS obviously but also because of some other things happening in my life (and probably because I unfortunately had to take quetiapine to sleep). And this was actually good because then I could see if the ALLO would indeed work or not.

Within 20-30 minutes after the shot, I started noticing the effects kicking in. And later on I was no longer depressed, my drive for life had comeback, my anxiety was nearly zero. My TMJ disfunction stopped. Everything was better and I was feeling like my older self essentially.

I took the shot during the day because the person who told me about this said that he talked with the sellers and they told him to take at morning time, but my next shot will be at the beginning of the night (for the insomnia), cause I experienced drowsiness and was sleepy until 5 hours after the shot at 2:30pm.

I now need to finish the vial and see how I’ll feel, I think I’ll keep taking 10mg so it can last longer. I’ll be buying more for sure and I’m trying to get access to Zuranolone via importation. I’m also buying Etifoxine (oral neurosteroids booster).

All I can say is that allopregnanolone is a miracle molecule, and to think we blocked this is insane (finasteride is pure poison). I say this because if you research, you’ll see that not only ALLO acts on GABA-A to promote its effects, but it also upregulates and modulates it. This is the opposite of what benzos do, benzos act on GABA-A but downregulate it over time.

This was just the first day and I need to finish the vial to see how I’ll feel afterwards. But maybe because we have PFS we need to be taking this for life or at least for a longer time than the 14 days used in depression. But maybe not cause we have reports of recovery with Etifoxine, GHB, and also Ketamine (although this one does not act on neurosteroids).

When it comes to ALLO medications, we just don’t have many reports/experiences because essentially, for some very suspicious reason, no one can get access to it (but get access to poisons like benzos). Brexanolone (the IV one) for example is approved since 2019, but heavily restricted and overpriced; and now the same is happening with zuranolone (very, very cheap in Japan though as I showed in my last post).

Now almost 24 hours later I’m feeling slightly better than before the shot (less depressed), but we know the official treatment consists of 14 days. This caproate ALLO will last less than that at 10mg (in the website it says 5-30mg per week). So that’s the update for now.

Both Google and Grok inform this. I just don’t understand how cheap medications can be so expensive in the US (I know health insurance covers it most of the time, but still atrocious, because of the off-label needs).

Google:

“In Japan, the official National Health Insurance (NHI) drug reimbursement price for Shionogi's ZURZUVAE Capsules 30 mg (generic name: zuranolone) is ¥646.80 per 30 mg capsule.

Treatment Cost Breakdown
Per Capsule: ¥646.80 (NHI price)

Standard Dosage: 1 capsule (30 mg) once daily after dinner for 14 days”

Grok:

“In Japan, the National Health Insurance (NHI) price (薬価) for zuranolone (ズラノロン) is 646.80 yen per 30 mg capsule (brand name: ザズベイカプセル30mg / Zazubei Capsule 30 mg, marketed by Shionogi).

It was approved in December 2025 for depression/depressive states (**うつ**病・うつ************状態) and listed on the NHI drug price list on March 18, 2026.

This is substantially lower than the U.S. list price for a 14-day course of Zurzuvae (around $15,900).”

We need to fight for this. I’ll try to import the medication to my country from Japan.

For those who don’t know, Zuranolone (allopregnanolone) upregulates, restores and modulates the GABA-A receptor. That’s why the treatment is only for 14 days (very similar to the treatment of depression using ketamine)!

This has been talked about on the forums since 2018 I think, as SAGE-217. Now it’s out since 2023 for postpartum depression as zuranolone, an oral allopregnanolone, which is very easy to use. But super restricted and highly expensive (when it shouldn’t be). Now imagine being from a third world country and trying to get access to this.

This disease is the worst in the world, cause it’s still not completely recognized, people around don’t seem to believe, and the stuff that could help us like a simple allopregnanolone supplementation is restricted from us when actually it should be readily available.

In Japan it’s already approved for depression and I think that we PFS sufferers can benefit much more than people with depression because we actually blocked the neurosteroid/enzyme with the poison called finasteride.

This is insane. I had no idea that “SAGE-217” was out and that it was zuranolone. I’m with a compound called allopregnanolone caproate here and I’ll probably be taking 10mg on Monday. I’m very positive it will help me. I’ll post an update here.

The thing is, why do I need to purchase allopregnanolone from a website from another country, pay taxes, the price is also not cheap, will have to inject it – when there’s also the approved medicine since 2023 as an oral, safe treatment? Big pharma’s BS, bureaucracy and conspiracy are insane.

Let’s remember allo acts on GABA-A just like benzos and other drugs and it could be a major hit on all those poison drugs, cause it doesn’t downregulate the receptors like benzos do, it actually enhances, restores balance and modulates them. And it’s something natural and technically a freaking supplement.

I have unbelievable insomnia and this certainly can help me tremendously, and it should be available right now. Even if it’s not a cure, it certainly can be a treatment.

But the big pharma and government BS is just insane. They’re the ones responsible for our disaster with finasteride to begin with, and even the newest treatment is being kept from us.

I started having success with it after a few days and with enough sleep pressure (waking up early, exercising) at 5mg. I actually started with 10mg but the anxiety and depression the next day is unbearable, and even benzos and pregabalin don’t help that much in controlling this. I think even antipsychotics didn’t make me feel this bad.

I read that this side effect doesn’t stop with time for some, but has those side effects improved over time for anyone here as the body adapts to it? Thanks.

Been dealing with this since the beginning, had lots of bruxism, crooked teeth (used myobrace system to straighten), couldn’t even explain what it was. But now I’m having this huge TMJ tension and I’m having some clicks and even some pops when it’s too tense.

I’m thinking about doing TRT and some other stuff. I’m currently doing low dose proviron but it’s not helping like when I used it the first time (it really relieved this until I crashed).

I wonder if this resolved for anyone cause it’s clear to me that this has something to do with hormones cause as I mentioned, Proviron helped 100% for a while.

This can maybe act similar to pregabalin in relieving the TMJ tension. But it’s totally different and it acts like an SSRI (which is interesting) but instead of serotonin, it acts on GABA. It’s a very unknown drug for some reason.

I’m pretty desperate, I got TMJD from finasteride (the post-finasteride syndrome), used myobrace system, my bottom teeth straightened after a while, but now 2 years later I’m having this huge TMJ tension and it seems it’s gonna explode at times, not to mention the clicking when it’s too tense.

I remember using low dose Proviron (synthetic DHT) in 2023 and in the second day I felt like I was 100%. But ended up crashing later on and everything came back. Tried again with no success and also had too much hair loss, maybe because I took higher doses at times, and then stopped.

There’s others in the PFS community with TMJ issues, so it’s obviously from finasteride. I think I’m going to a TMJ specialist in my country but also try some other hormone approaches (I’m trying Proviron again but no success). This is hell on earth, it totally takes your comfort and confidence away 24/7.

It’s been a while since I restarted trying Dayvigo but I’m not taking it regularly (like every day) because of this anxiety and depression. It’s just horrible. But Dayvigo is what’s left for me and it’s working for insomnia for the most part and I like it’s impact on sleep.

I know there’s info and anecdotes about this anxiety/depression going away with time but it doesn’t seem to be the case for me. It seems to be some metabolite or something.

Cause last night I slept at 9:40pm, woke up around 6am feeling fine, no depression or anxiety, but at 9am this nightmare started again. I really need this to go away cause it’s indeed bad and I’m taking only 5mg.

Thanks.

This is another medication that seems hidden from the public, just like GHB, allopregnanolone, andractim.

It acts like an SSRI but instead of serotonin, it acts on elevating the levels of GABA in the brain. This might help with anxiety, sleep (it increases slow-wave sleep, which is deep sleep) and maybe mood as well.

Not to mention I’m dealing with tingling in hands and feet and TMJ disorder. Maybe it’ll help with that as well.

This medication is not available in my country and I’ll have to import it and I don’t think it’ll be cheap.

I’m trying it now instead of Dayvigo because Dayvigo gives me bad anxiety and depression the next day because of the long half-life. I wonder if maybe I should try 75mg Quviviq cause 50mg didn’t do much. I was expecting it to actually hit harder cause it acts faster than Dayvigo.

I struggle with insomnia and I can take up to 50mg of baclofen and don’t feel any sleep at all. Maybe 60-80mg can give me some sleep? Good thing is that baclofen at 40mg+ also helps me not wake up in the middle of the night.

I realized that after developing BFS and then sleeping early for a month non-intentionally in 2018. I guess I was just very sleep deprived (sleeping too little) and back then I was editing videos all day and would get tired early.

So I was sleeping around 7:30-8pm and waking up around 5am. All my BFS symptoms disappeared. Unfortunately I didn’t even know what I had as I was very scared, thought the reversal was due to diet changes as at first I thought it was something linked to arteries/heart, and started sleeping late again and not enough and everything came back (BFS is linked to sleep deprivation).

So I saw this as a sign from the Most High showing to me that sleep was the key to reverse this. Tried to replicate this without meds (in 2018 I wasn’t taking any meds) with no success and since then I’ve been using meds.

Because of the need to sleep at the right time, I developed anxiety before sleep (it’s like racing against time, cause if I don’t sleep on time the next day I’m full of fasciculations and nerve pain). And the limit for me is 11pm.

Even though I haven’t been able to fully reverse the syndrome, at least I can say it’s under control. This last night I took quetiapine and was able to sleep around 9pm and woke up at 6:10am. I’m using baclofen too so I don’t wake up in the middle of the night and it works great.

So I’m very optimistic that I’ll finally be able to reverse this nightmare of a syndrome, cause without baclofen if I sleep around 9pm I always wake up way too early. So now I’m finally able to sleep early without losing my sleep in the middle of the night.

I’m also focusing on heavy exercise (doing Muay Thai now) so there’s adenosine buildup in the brain and then I can take lower doses of these meds.

A big problem with quetiapine and antipsychotics is that after 4-5 days on it for sleep my mental health gets really bad. I use pregabalin and it helps a lot but can’t take it everyday because of tolerance.

But that’s it, sleeping early is so important to get real restorative sleep and it’s no wonder that people like Bryan Johnson sleep at 8:30pm. It’s simply incredible.

Baclofen has been amazing for me for sleep maintenance. Now I can sleep early and not wake up in the middle of the night with no sleep for the first time in my life. But from my experience it has to be 40mg. And from what I researched, doses above 20mg can disrupt REM sleep.

And I have BFS (fasciculation syndrome) and it’s linked to sleep, and even though I’m sleeping early and for 9 hours (the ideal for me to reverse the syndrome), I’m still waking up feeling like the sleep wasn’t enough.

Should I get the dose down to 25-35mg? I remember 30mg not being enough and 20mg not working at all. Or maybe take 20mg around 6pm and then a second dose right before bed of 20-30mg?