u/yshcrp

Was watching Prof. Melcangi’s interview with SIDEfxHUB and he mentions this. This would explain the sexual disfunction cause this enzyme is very important for it. And this enzyme is also affected in PSSD, which can explain the nearly identical sexual issues in both syndromes.

In Addition to Blocking 5α-R, Finasteride Inhibits Adrenaline Production, Possibly Inducing Sexual and Psychological Side Effects, New Research Suggests:

https://www.pfsfoundation.org/news/in-addition-to-blocking-5%CE%B1-r-finasteride-inhibits-adrenaline-production-possibly-inducing-sexual-and-psychological-side-effects-new-research-suggests

Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close:

https://www.sciencedirect.com/science/article/pii/S0091302223000626

Had no idea about this. Google about how to boost this enzyme:

"Phenylethanolamine N-methyltransferase (PNMT) activity can be boosted biologically through exposure to physiological stress, adequate levels of the cofactor S-adenosylmethionine (SAM), and stimulation by glucocorticoids (cortisol/corticosterone).

How PNMT is Regulated and Supported
Glucocorticoids: High levels of cortisol or corticosterone from the adrenal cortex naturally induce and maintain PNMT gene expression and enzyme activity in the adrenal medulla. [1, 2]

Stress Stimuli: Acute or repeated physiological stressors (such as immobilization stress or cold exposure) significantly upregulate PNMT gene expression and elevate adrenaline synthesis. [1, 2]

Cofactor Availability: SAM (S-adenosylmethionine) acts as the essential methyl donor for PNMT to convert norepinephrine into epinephrine; it also helps stabilize the enzyme structure and extend its half-life. [1, 2, 3]"

I used SAM-e in the past after developing PFS for joints and depression but wasn’t for long. Didn’t have any crash nor improvement and didn’t find anything about SAM-e here but on Propecia Help there’s a post about PSSD induced by SAM-e.

Had watched a small part of this documentary as a video on YouTube but never the full documentary. Very good info. We definitely need to share this as much as we can.

It exposes Merck’s corruption, talks to experts, patients, and with mothers of victims of the poison. Finasteride needs to be banned as soon as possible and Merck needs to be held accountable for its crimes.

Merck Manipulated the Science about the Drug Vioxx

Scientists from the pharmaceutical giant Merck skewed the results of clinical trials in favor of the arthritis drug, Vioxx, to hide evidence that the drug increased patients’ risk of heart attack.

To increase the likelihood of FDA approval for its anti-inflammatory and arthritis drug Vioxx, the pharmaceutical giant Merck used flawed methodologies biased toward predetermined results to exaggerate the drug’s positive effects. Internal documents made public in litigation revealed that a Merck marketing team had developed a strategy called ADVANTAGE (Assessment of Differences between Vioxx And Naproxen To Ascertain Gastrointestinal tolerability and Effectiveness) to skew the results of clinical trials in the drug’s favor. As part of the strategy, scientists manipulated the trial design by comparing the drug to naproxen, a pain reliever sold under brand names such as Aleve, rather than to a placebo.

The scientists highlighted the results that naproxen decreased the risk of heart attack by 80 percent, and downplayed results showing that Vioxx increased the risk of heart attack by 400 percent. This misleading presentation of the evidence made it look like naproxen was protecting patients from heart attacks, and that Vioxx only looked risky by comparison. In fact, Vioxx has since been found to significantly increase cardiovascular risk, leading Merck to withdraw the product from the market in 2004.

Merck’s manipulation of the science around Vioxx also included a pattern of ghostwriting of scientific articles. Internal documents reveal that in 16 of 20 papers reporting on clinical trials of Vioxx, a Merck employee was initially listed as the lead author of the first draft; on the published versions, an outside academic was listed as the primary author. In one draft of a Vioxx research study that did not yet have a prominent outside name attached, Merck officials listed the lead author only as “External author?” A Merck scientist was also found to have removed the evidence of three heart attacks among patients in a dataset from the results presented.

Tragically, Merck’s manipulation of its data—and the FDA’s resulting approval of Vioxx in 1999—led to thousands of avoidable premature deaths and 100,000 heart attacks. Dr. David Graham, the Associate Director for Science and Medicine in FDA’s Office of Drug Safety, testified in 2004 before the Senate Finance Committee that the FDA's failure to recall Vioxx earlier had resulted in as many as 55,000 premature deaths from heart attacks and stroke, calling it the equivalent of allowing "two to four jumbo jetliners" to crash every week for five years. Even years after discontinuing use of the drug, patients who have taken Vioxx continue to experience complications.

https://www.ucs.org/resources/merck-manipulated-science-about-drug-vioxx

And people wanna say Merck wouldn’t do the same with finasteride, hah. In fact, we now know 100% they did:

https://www.reuters.com/investigates/special-report/usa-courts-secrecy-propecia/

As expected, the conman lost to Zach after suing him and asking for 30 million (lol) because Zach exposed him for his frauds.

Jake Claver exposed: https://youtu.be/nl8A3OD2NIw

Allopregnanolone is a key and potent neurosteroid derived from progesterone. It’s approved since 2019 for postpartum depression (brexanolone, IV use). Now they are using it in capsules and it’s called zuranolone.

With brexanolone, because it was IV, the job was done in just 2.5 days. With zuranolone, in 14 days. It didn’t get approved for depression in the US (which I believe was to protect the other drugs, including benzos) and it’s very expensive/overpriced (around 16k total for the 14 days). But it was approved in December of 2025 in Japan for depression (MDD) and it’s very cheap (4 dollars per capsule).

I’m currently using it but it’s because I’m dealing with post-finasteride syndrome, as finasteride blocks the conversion of progesterone to allopregnanolone by blocking the 5AR enzyme. And studies have shown very low levels of neurosteroids in PFS patients.

The first two times injecting I took 100mg by mistake (1ml), but the effect was very good and it did relieve my PFS symptoms, including the neuropathy, as ALLO works on GABA-A and it actually upregulates the receptors (the opposite of what benzos, for example, do).

But the thing is not using ALLO just to temporarily relieve the symptoms. Studies have shown that ALLO can actually repair the myelin sheath, as it acts directly on the cells responsible for myelination (oligodendrocytes and Schwann cells) to promote white matter regeneration.

You can do your own research for more details. I just really needed to share this and create more awareness about this substance – which in my opinion is clearly a miracle molecule.

I’m using the substance (buying from a website; it’s not brexanolone nor zuranolone) with a protocol more focused on the post-finasteride syndrome (PFS), which is 30mg three times per week (I’m much better mentally after 6 injections [first two, as mentioned, were 100mg by mistake]).

But I already ordered more and want to keep using it with the focus of healing my neuropathy, which maybe requires to be taking it everyday (I need to do more research) for the myelin repair.

I’m also using supplements like R-ALA, benfotiamine, L-citrulline, ALCAR, folate and B12; and focusing on exercising and getting proper sleep (sleeping early/at the proper time and for enough hours).

But I was blown away by this info about ALLO and I feel like this substance is being held hostage by big pharma and being hidden from the public. I also have two people in my family with multiple sclerosis and this could be helpful for them as well because of the myelin repair.

Alternatives to real ALLO are Etifoxine (anxiety medication from France that works by boosting ALLO) and progesterone (more suitable for women as it is a female hormone).

Already knew about this after I developed BFS (fasciculation syndrome). I have it since 2018 and I ended realizing that sleeping early and for enough hours reverses the BFS, cause around November of 2018 I slept very early (non-intentionally) and woke up very early for a month and all the symptoms disappeared.

Unfortunately I was so scared that I didn’t even know what I had and didn’t have any diagnosis yet. I thought the improvement was due to diet and ended up sleeping late and not enough again (sleep deprivation is one of the causes of BFS) and everything came back.

Now since I developed peripheral neuropathy (probably from a medication), the first thing that came to my mind was sleeping early to reverse it and indeed it does that.

Main problem for me with these diseases is that I have insomnia and need not only to sleep early but also to sleep for 9 hours (I’ve been using meds). I notice that even if I sleep early (like 9pm/10pm) but do not sleep for the 9 hours I wake up with the symptoms.

But if I sleep early and for 9 hours, I wake up feeling the symptoms improve/diminish. I hope this can help you. Research about sleeping early and its benefits, it’s so important because of getting real restorative sleep.

So as you guys know at the first week on the allopregnanolone caproate I actually took by mistake 100mg (1ml) twice. That’s 200mg in just two days, and although I felt awesome on it with the effects, it’s not the right therapeutical dose.

So then I stopped and waited until Monday of this week and started taking 30mg. The website says 10-70mg per week, but I emailed them asking if because I have PFS if I couldn’t take a little more than that, which is 30mg Monday, Wednesday and Friday.

They said it makes sense. So it’s already 290mg in two weeks because of the mistake. After the second 30mg dose on Wednesday I felt like the depression was nearly gone (Zuranolone fixes depression in 14 days; Brexanolone, the IV one, in 2.5 days).

So yesterday I woke up already feeling like the depression was pretty much gone. I did wake up with anxiety at waking up (one of my PFS symptoms that made a return recently), but I think it was because I had to take 8mg Ramelteon (can cause anxiety) and 25mg propanolol (rebound effect) cause I had a problem with my father and needed to calm down and sleep.

Also on Tuesday my Andractim gel arrived and I immediately started using it on the penis and testicles. I can definitely tell it’s helping a lot. Wednesday I had to go to the hospital to do some exams and I was feeling very confident, like my older self (or even better), my TMJD was also much better and relieved.

Not to mention the effects on my penis, yesterday for the first time in three years I looked at it before showering and it was basically normal (I’ve been avoiding looking at it flaccid so I wouldn’t get even worse mentally). It’s also not feeling like jelly anymore. Libido is much better as well.

So three hours ago I took my 30mg shot of the allopregnanolone caproate and I’m feeling pretty fine, no depression nor anxiety (already woke up without anxiety and depression today), TMJ is fine, peripheral neuropathy fine as well, good motivation and euphoria. And also applied the Andractim, which, as mentioned, is helping greatly as well.

So that’s the update for now. Neurosteroids are miracle molecules and finasteride should be banned (just like Vioxx, which was also from Merck and killed thousands, was banned). Let’s remember ALLO is being used for depression and it does the job in a few days; I truly believe Zuranolone was not approved for depression in the US to protect the other poison pills that need to be taken for life.

It was approved in Japan though with great success and it’s very cheap over there (4 bucks per capsule), but in the US it’s 16k (!) for the 14 days. We need other countries to do the same!

Not to mention that it upregulates GABA-A, the complete opposite of benzos which are addictive as they downregulate the receptors. So this stuff could be used for anxiety disorders as well, just like Etifoxine (ALLO bosting med) is used in many countries for that purpose.

I’m definitely feeling better and I didn’t even finish the treatment, especially with Andractim, which I just recently started on Tuesday of this week. And let’s also not forget that DHT turns into 3-alpha-androstenediol which is a potent positive allosteric modulator of the GABA-A receptor.

That’s the update for now, guys. There is hope. Keep fighting, seek treatment. Never give up. Take care.