I struggle with insomnia and I can take up to 50mg of baclofen and don’t feel any sleep at all. Maybe 60-80mg can give me some sleep? Good thing is that baclofen at 40mg+ also helps me not wake up in the middle of the night.
Because it induces such a restorative sleep, this indeed happens, which can actually classify GHB (Xywav/Xyrem/Lumryz) as a nootropic when used for sleep purposes. This can also be attributed to the dopamine and glutamate rebound that occurs after GHB wears off.
Narcoleptics using it medically (Xywav) also confirm that it helps with brain fog:
New comment on one of my posts exposing Jake.
I realized that after developing BFS and then sleeping early for a month non-intentionally in 2018. I guess I was just very sleep deprived (sleeping too little) and back then I was editing videos all day and would get tired early.
So I was sleeping around 7:30-8pm and waking up around 5am. All my BFS symptoms disappeared. Unfortunately I didn’t even know what I had as I was very scared, thought the reversal was due to diet changes as at first I thought it was something linked to arteries/heart, and started sleeping late again and not enough and everything came back (BFS is linked to sleep deprivation).
So I saw this as a sign from the Most High showing to me that sleep was the key to reverse this. Tried to replicate this without meds (in 2018 I wasn’t taking any meds) with no success and since then I’ve been using meds.
Because of the need to sleep at the right time, I developed anxiety before sleep (it’s like racing against time, cause if I don’t sleep on time the next day I’m full of fasciculations and nerve pain). And the limit for me is 11pm.
Even though I haven’t been able to fully reverse the syndrome, at least I can say it’s under control. This last night I took quetiapine and was able to sleep around 9pm and woke up at 6:10am. I’m using baclofen too so I don’t wake up in the middle of the night and it works great.
So I’m very optimistic that I’ll finally be able to reverse this nightmare of a syndrome, cause without baclofen if I sleep around 9pm I always wake up way too early. So now I’m finally able to sleep early without losing my sleep in the middle of the night.
I’m also focusing on heavy exercise (doing Muay Thai now) so there’s adenosine buildup in the brain and then I can take lower doses of these meds.
A big problem with quetiapine and antipsychotics is that after 4-5 days on it for sleep my mental health gets really bad. I use pregabalin and it helps a lot but can’t take it everyday because of tolerance.
But that’s it, sleeping early is so important to get real restorative sleep and it’s no wonder that people like Bryan Johnson sleep at 8:30pm. It’s simply incredible.
Baclofen has been amazing for me for sleep maintenance. Now I can sleep early and not wake up in the middle of the night with no sleep for the first time in my life. But from my experience it has to be 40mg. And from what I researched, doses above 20mg can disrupt REM sleep.
And I have BFS (fasciculation syndrome) and it’s linked to sleep, and even though I’m sleeping early and for 9 hours (the ideal for me to reverse the syndrome), I’m still waking up feeling like the sleep wasn’t enough.
Should I get the dose down to 25-35mg? I remember 30mg not being enough and 20mg not working at all. Or maybe take 20mg around 6pm and then a second dose right before bed of 20-30mg?
Other conditions that Google mentions:
• Fibromyalgia: Historically studied and prescribed off-label for managing widespread pain and improving restorative sleep in severe cases.
• Parkinson's Disease-Related Sleep Issues:
Used for managing severe sleep fragmentation or hypersomnia secondary to Parkinson's.
• Chronic Pain & Neuropathy: Sometimes utilized off-label to manage refractory neuropathic pain by modulating neurotransmitter activity.
• Alcohol Withdrawal: In some clinical research settings, oxybate formulations have been explored to manage severe alcohol withdrawal symptoms.
• Dystonia: Specifically in patients with alcohol-responsive dystonia and spasmodic dysphonia.
• Anxiety Disorders: There are exploratory studies on its effectiveness in reducing symptoms of severe anxiety.
• Treatment-Resistant Depression: It is sometimes considered for patients who have not responded to standard antidepressants, though it is not a first-line treatment.
When will, at least, this corruption on the price end? The conspiracy against this substance is forever? I never seen anything like it.
GOOGLE:
Between its initial FDA approval in 2002 and 2014, the list price for sodium oxybate (Xyrem) surged by 841%.
Key Price Milestones (Xyrem)
• 2007: The annual cost was roughly $11,169.
• 2014: The annual cost reached $106,215.
• Recent (2025/2026): The annual list price for brand-name Xyrem rose to over $182,000), although the entry of authorized generics in 2023 has dropped the retail price to roughly $5,200 for 180ml or about $10,000 per month without insurance.
Jazz Pharmaceuticals has recently resolved multiple high-profile antitrust and patent lawsuits. Most notably, they paid $145 million to resolve claims that they conspired with Hikma Pharmaceuticals to delay the launch of generic alternatives to their narcolepsy drug, Xyrem. They also reached a global settlement resolving multi-front litigation with Avadel Pharmaceuticals.
Other conditions:
• Fibromyalgia: Historically studied and prescribed off-label for managing widespread pain and improving restorative sleep in severe cases.
• Parkinson's Disease-Related Sleep Issues:
Used for managing severe sleep fragmentation or hypersomnia secondary to Parkinson's.
• Chronic Pain & Neuropathy: Sometimes utilized off-label to manage refractory neuropathic pain by modulating neurotransmitter activity.
• Alcohol Withdrawal: In some clinical research settings, oxybate formulations have been explored to manage severe alcohol withdrawal symptoms.
• Dystonia: Specifically in patients with alcohol-responsive dystonia and spasmodic dysphonia.
• Anxiety Disorders: There are exploratory studies on its effectiveness in reducing symptoms of severe anxiety.
• Treatment-Resistant Depression: It is sometimes considered for patients who have not responded to standard antidepressants, though it is not a first-line treatment.
When will, at least, this corruption on the price end? The conspiracy against this substance is forever? I never seen anything like it.
GOOGLE:
Between its initial FDA approval in 2002 and 2014, the list price for sodium oxybate (Xyrem) surged by 841%.
Key Price Milestones (Xyrem)
• 2007: The annual cost was roughly $11,169.
• 2014: The annual cost reached $106,215.
• Recent (2025/2026): The annual list price for brand-name Xyrem rose to over $182,000), although the entry of authorized generics in 2023 has dropped the retail price to roughly $5,200 for 180ml or about $10,000 per month without insurance.
Jazz Pharmaceuticals has recently resolved multiple high-profile antitrust and patent lawsuits. Most notably, they paid $145 million to resolve claims that they conspired with Hikma Pharmaceuticals to delay the launch of generic alternatives to their narcolepsy drug, Xyrem. They also reached a global settlement resolving multi-front litigation with Avadel Pharmaceuticals.
While the Creator’s Name was hidden (jewish law, YHWH to “Lord/Kyrius” tradition in the Bible), the Messiah’s Name went from YAUSHA (יהושע) to Yeshu/Yeshua (ישוע) then Iesous and then Iesus (I’m not even gonna mention this name’s meaning because you’re not prepared, but research “ie” and “sus” in latin).
Yeshu/Yeshua according to rabbis means “may his name be forgotten forever” as an acronym, which fulfilled Jeremiah’s prophecy:
“I had been like a gentle lamb led to the slaughter; I did not realize that they had plotted against me, saying, “Let us destroy the tree and its fruit; let us cut him off from the land of the living, that his name be remembered no more.” Yrmyau (Jeremiah) 11:19
I’m gonna leave you guys with this video which shows archaeological proof and the Yaudim (Jews) themselves pronouncing the Name in the names of prophets (Numbers 6:27):
And this one is in Portuguese but it shows them evoking the Name when they’re being attacked with missiles (Psalms 50:15):
I think my brain has had enough of this. Started with antihistamines, then seroquel for a year and a half (it worked with heavy BJJ training but stopped when I realized it was literally destroying my psyche), then mirtazapine (never really worked), then benzos (rohypnol was the main one), then came back to seroquel (and clozapine) with the idea of rotating it before the psych side effects start (around the 5th day).
But because of a knee injury I had to stop BJJ training and haven’t been able to return yet, and seroquel isn’t working properly anymore, that’s why I added low dose clozapine as a last resort (25mg max because of dangerous side effects). I’m worried about how my brain might be affected from all of this (rebound insomnia, GABA problems).
This last night I was able to sleep with clonidine 100mcg (first time using it) even though I was experiencing heart palpitations from it, but woke up at 3:30am with the insane barking from my neighbor’s dog (I’m about to move) and couldn’t sleep anymore (tried alprazolam and melatonin).
The thing is, nothing works except clozapine, and I’m worried even that will stop working too at one point (25mg used to knock me out, but recently had nights in which it didn’t work). And clozapine’s mental side effects are even worse as it is the strongest antipsychotic.
So I’m gonna listen to my aunt and to a friend of mine who told me about walking until getting very tired and see what happens. I already woke up early and I’m exposing myself to the sunset light. And at midday, if I’m healthy enough (cause I have benign fasciculation syndrome and recently developed paresthesia on hands and feet, a common and well-documented secondary symptom of the syndrome – which gets worse when I don’t sleep properly), I’m gonna train Muay Thai.
I only started meds because of my syndrome, as it started in 2018 after sleep deprivation (one of the known causes), and around November 2018 after not sleeping much I felt really tired around 7:30pm and went to sleep. Woke up around 5am and did this for an entire month (unintentionally) and all my symptoms subsided.
Unfortunately I didn’t make the connection with sleep (thought it was diet because I still didn’t know what I had as I was very scared) and started sleeping late and not enough again and all the symptoms came back. I tried to recreate this early sleeping with no meds but to no avail. But I’m gonna try again.
I also started to have heart palpitations and certainly arrhythmias, and that started certainly when I tried 150mg doxepin (it’s a known side effect, unfortunate cause it worked very well at this dose); because that’s when I first had this arrhythmia/palpitation stuff. It was happening with mirtazapine too, especially when I couldn’t sleep well. I know that if I sleep well and enough this stops just like my other symptoms do.
So I’m gonna “walk for my life”, train and see what happens, cause the more hours awake we are and the more we exercise, the more adenosine we build in our brains (sleep molecule). And that’s what I’m gonna try to do.
I also know that in 2018 in that month when I woke up early, at least in some of those days, I’d get my car and drive and go to a supermarket or something. It was a very nice feeling waking up at 4, 5am when it was still dark and with little to no people in the streets. It’s also important to do that because of getting exposed to the sunset, which signals the brain that the day started.
And to finish, about walking, I remember that in 2024 I went to an outlet and when I was leaving at the afternoon I couldn’t remember where I parked and had to walk a lot with some quite heavy bags, and at night I felt really tired and could’ve certainly slept with no meds, but still took some mirtazapine to make sure I’d sleep. I also hadn’t slept much that day.
I think pharma failed us with all those meds that don’t work and have bad side effects, and then the off-label ones. Not to mention that in extreme cases involving sleep deprivation, access to strong approved meds like oxybates should be available before more people develop what I developed.
Wish me luck. Thanks.
There is a website strictly with compounds for 5ar and the name says so. I don’t know if I can mention it here so you all can just google “allopregnanolone caproate”. They also sell a regular allopregnanolone and also Allopregnanolone Lavender Sleep Balm – 30mL (150mg).
Has anyone tried any type of allopregnanolone? I know there’s a medication called brexanolone (Zulresso), but it’s a Schedule IV controlled substance:
GOOGLE:
“Allopregnanolone (also known as brexanolone or Zulresso) is a regulated substance. [1, 2, 3, 4]
Legal & Medical Status: In the United States, it is a Schedule IV controlled substance. The pure compound and its medical formulations are tightly restricted and require strict medical supervision or a valid, targeted prescription.
Medical Use: It is FDA-approved under the brand name Zulresso for the treatment of postpartum depression. Because of potential side effects like excessive sedation and sudden loss of consciousness, its clinical use is restricted to certified healthcare facilities with a continuous 60-hour intravenous infusion.
Synthetic Options: Oral alternatives, such as zuranolone (Zurzuvae), are also heavily monitored medications used for major and postpartum depression.
Research & Lab Use: If you are looking to acquire allopregnanolone for scientific research, specialized chemical vendors classify it as a restricted compound requiring specific permits and licensure.
Action: It acts on GABA-A receptors in the brain, having a strong anxiolytic and mood-stabilizing effect.”
If anyone has tried can you please share your experience with it?
*This post is for informational purposes
*I’m not promoting anything nor a quick fix
A cheap compound for 100k?
“GHB is a remarkable molecule because it can suppress depressive ideation and anxiety, sometimes within less than 30 minutes. It also seems to be immediately active on the most severe and treatment-resistant forms of depression. Because of such remarkable properties I jokingly used to call GHB "Or Potable", which means "drinkable gold" in French! Indeed a molecule which can block your depression and suicidal ideas, anxiety, etc, in such an efficient way is as precious as gold because it can save your life. GHB saved my own life many times when all other antidepressants failed.”
Claude Rifat
The Great GHB Debate
Behind the media reports is an intense GHB debate comprised of two very vocal opposing factions — on the one side is the FDA, DEA, and families whose loved ones reportedly died of GHB overdose. This is the group that has conducted a public awareness campaign and is responsible for getting GHB made into a Schedule I drug.
On the other side of the debate is a much smaller group of doctors, researchers, and GHB users, including narcoleptics, who are sometimes prescribed GHB to treat their debilitating daytime sleeping disorder. This group claims GHB is an exceedingly safe and useful substance that has been banned for the benefit of pharmaceutical companies, who they say are intrinsically intertwined with the FDA. They point out that the mainstream press often refers to GHB as a ‘designer drug’, but it is a natural substance found in meat and vegetables and every cell of the human body.
Central to the debate is the case of Hillory Farias, a seventeen-year-old La Porte, Texas, girl whose 1996 death was attributed to GHB overdose. Before the Farias case, no death had been attributed exclusively to GHB ingestion alone.
Dr. Ward Dean, co-author of ‘GHB: The Natural Mood Enhancer’, describes GHB as “one of the most useful substances known to man.” He is so confident in GHB and its precursor chemicals’ safety that he gives it to his kids to help them sleep.
After studying the autopsy report, Dean and his team say GHB had nothing to do Farias’ death. First, the amount of GHB found in Farias’ body isn’t even enough to get someone high.
In clinical studies, rats are regularly given many times that amount of GHB without dying. Narcoleptics use much higher doses of GHB daily without any reported side effects and three grams of GHB is typically prescribed to induce sleep. They also point out that Farias died in her sleep many hours after getting home.
Since GHB is a fast acting molecule, any effects from unusual toxicity would have showed up within an hour, they say. GHB overdose causes deep sleep within minutes, but Farias was able to say goodbye to her friends, get out of the car, get inside her house and climb into bed on her own.
Also GHB is naturally found in the blood post-mortem, says Dean. Up to 168 milligrams have been found in the blood of cadavers that had not ingested any GHB. Dean believes that that body can produce huge amounts of GHB at the time of death as a way to try and protect the brain and organs from low oxygen levels, thus essentially any death can be attributed to GHB ingestion if that’s what investigators are seeking.
Dean and his team say the coroner eventually determined that Farias suffered from a congenital heart disease, and died as the result of a blood clot. Nevertheless, the title of the bill that President Bill Clinton signed is officially called the Hillory J. Farias and Samantha Reid Date-Rape Drug Prohibition Act (although neither of the girls were sexually assaulted).
In Samantha Reid’s case, she died the day after GHB ingestion. The death was blamed on GHB, although the drug leaves the body within a matter of hours. Reid’s parents were conspicuously absent from the list of people who testified in support of the bill named after their daughter.
Full article: https://andewanderer.com/?portfolio=ghb-death-of-a-party-drug
Guys, I’m struggling a lot with my severe insomnia and fasciculation syndrome (which is linked to sleep deprivation and gets worse when I don’t sleep well).
Right now I’m relying on antipsychotics but they destroy me psychologically after a few days of usage and not to mention the long list of side effects they have, which include prolonged QT syndrome, which can cause deadly arrhythmias. And for a year now I started to have heart palpitations so I’m super cautious now with these drugs.
So because it’s impossible for me to get pharma GHB in Xywav, I’m thinking about trying BD again. I’m suffering with this syndrome for 8 years now and I know that to get better I need to sleep at an appropriate time and for enough hours, which unfortunately for me is 9 hours.
I used NaGHB but was only getting 2-3 hours max per 4.5g dose and was having to take 4 doses to get the 9 hours and feel better but it’s way too much sodium and I had high blood pressure, so I had to stop using it. But it was working tremendously for the insomnia and the sleep. It was something that I could rely on knowing that it would work.
Talked with nearly all the vendors on DW and no one has K-GHB nor were willing to try and make it. So what’s left is trying BD again, even if it’s just occasionally.
Does anyone here have experience with BD strictly for sleep or at very moderate doses? Cause I know some people claim no side effects with it and also say side effects might be from impurities and not from BD it self.
There’s also 1,3 BD which is now sold in beverages (Ketohol) and it’s literally the same as 1,4 but it gets converted into BHB in the liver instead of GHB. If you research you’ll see that 1,4 BD is not for human consumption because it turns into GHB. But we know GHB is non-toxic at therapeutic doses.
I’m not here promoting 1,4 BD, I’m just asking questions cause I’m really struggling to get my life back. Benign fasciculation syndrome is no joke, the neuropathic pain and twitching are horrible, not to mention I also developed weakness.
Thanks.
My BFS 100% started after sleep deprivation. Now I know that to get better I need to sleep properly which means at the right time and for enough hours (I know this from my own experience dealing with this for 8 years).
Xywav is low-sodium GHB. GHB is a tremendously effective sleep aid and the best medication for severe sleep disorders. I have severe insomnia, and that’s why I can’t reverse the syndrome like I did at one point and have to rely on bad medications like antipsychotics.
I actually got GHB (sodium-GHB) and it was working tremendously. The problem is that is too much sodium and the half-life is short, so I was needing 4 doses of it to get enough sleep (I need at least 9 hours).
So Xywav would be perfect because it’s low in sodium and I’d be able to take those 4 doses with no problems (would just have to manage possible glutamate rebound [but this usually goes away as the body adjusts to it, cause GHB is naturally occurring in our bodies]).
So we should fight for this. Not to mention that GHB relieves the neuropathic pain and twitching very well (just doesn’t last as long). The thing is that because it relieves the pain and twitching so well, it could be very helpful for those having a hard time sleeping because of the symptoms.
In 2018 I was able to reverse this disease by sleeping early for an entire month. Sadly I didn’t know what I had was BFS, thought it was the change in diet and started sleeping late again and everything came back and since then I haven’t been able to recreate what I did in 2018.
In 2022-2023 I started using quetiapine alongside with heavy BJJ training and was able to get a lot better. Not as good as in 2018 cause I was sleeping around 10pm and sometimes I’d sleep around 9pm and wake up in the middle of the night with no sleep at all and that would set me back cause I’d take another dose of quetiapine but many times I was awake for 2 or 3 hours before I’d sleep again.
And the problem with quetiapine is that it makes me so anxious, depressed and anhedonic after 5 or 6 days using it. So I have to take breaks. I’m also using clozapine and that’s the strongest antipsychotic there is so this one is even worse (after 3 days I’m already really bad psychologically).
Not to mention I started having heart palpitations and this meds can induce prolonged QT syndrome, which can cause deadly arrhythmias. So I’m very cautious these days with these meds.
So Xywav would be very beneficial for us. And as I said, I used the GHB and it was working great and I was getting better. Stopped using because of the high sodium (had high blood pressure). I’m trying to get potassium-GHB but no one has it right now.
Links about GHB:
GHB: Best medication to treat severe sleep disorder:
https://news.uthscsa.edu/ghb-best-medication-to-treat-severe-sleep-disorder
The effects of gamma-hydroxybutyrate on sleep:
https://pubmed.ncbi.nlm.nih.gov/192353
Dr. Ward Dean on
GHB: The One Substance to really promote sound, restful sleep; Anti-Aging effects; Big Pharma conspiracy
Yes There's A Miracle Cure For Insomnia & Addiction!
GHB: The Natural Mood Enhancer (Book):
Alcohol (ethanol) is generally much worse for the liver than 1,4-butanediol (1,4-BD), especially with chronic or heavy use. pubmed.ncbi.nlm.nih.gov
Alcohol (Ethanol) and Liver Damage
Ethanol is a well-established hepatotoxin. Chronic heavy consumption leads to:
• Alcoholic fatty liver (steatosis), alcoholic hepatitis, fibrosis, and cirrhosis.
• It causes oxidative stress, inflammation, fat accumulation, and cell death in the liver via metabolism (primarily by alcohol dehydrogenase and aldehyde dehydrogenase, producing acetaldehyde and reactive oxygen species).
• Epidemiology: Alcohol-associated liver disease (ALD) affects millions globally (prevalence around 4-5% in general populations, much higher in heavy drinkers). It accounts for a large share of liver disease deaths, cirrhosis cases, and transplants. Mortality rates have risen significantly in recent years. pubmed.ncbi.nlm.nih.gov
This is dose- and duration-dependent, with risks escalating over years of regular heavy drinking. Many people develop irreversible damage.
1,4-Butanediol (1,4-BD) and Liver Effects
1,4-BD is an industrial solvent and GHB precursor. It is metabolized in the liver primarily by alcohol dehydrogenase (ADH) to gamma-hydroxybutyraldehyde, then to GHB (via aldehyde dehydrogenase). This shares metabolic pathways with ethanol, leading to competitive inhibition when both are present. pmc.ncbi.nlm.nih.gov
Evidence on hepatotoxicity:
• Animal studies (e.g., rats) show mild-to-moderate liver inflammation or minor changes at high doses (e.g., 500 mg/kg), but not severe or statistically strong organ-specific toxicity in subchronic studies. No strong carcinogenic signal. ntp.niehs.nih.gov
• In human recreational/chronic misuse (often high/frequent doses), reports mention toxic hepatitis as a complication, along with other organ effects (kidneys, heart, etc.). This occurs in the context of heavy polydrug or compulsive use. pmc.ncbi.nlm.nih.gov
• Acute overdoses can cause severe effects (respiratory depression, coma, death), sometimes mimicking toxic alcohol poisoning, but liver damage is not the primary acute feature. Co-ingestion with ethanol can worsen outcomes, including increased mortality and tissue damage in animal models (due to competition for ADH, leading to higher levels of the parent compound or altered kinetics). pubmed.ncbi.nlm.nih.gov
1,4-BD lacks the extensive long-term population data of alcohol; use is less common and often episodic or addictive in specific contexts rather than a daily societal norm.
Key Comparison and Caveats
• Chronic exposure: Ethanol has far stronger, dose-dependent evidence for progressive liver scarring and failure. 1,4-BD can contribute to toxic hepatitis in heavy users but appears less potent per se for long-term fibrotic/cirrhotic disease.
• Acute/high-dose: Both are risky; 1,4-BD has a narrower therapeutic window for CNS/respiratory depression (via GHB), and mixing with alcohol is particularly hazardous. nejm.org
• Individual factors: Genetics (e.g., ADH/ALDH variants), dose, frequency, nutrition, and co-exposures matter for both. Neither is “safe.”
• Neither is recommended: 1,4-BD is not for human consumption and carries risks of addiction, overdose, and multi-organ toxicity.
Bottom line: Alcohol poses a substantially greater overall risk to the liver due to its prevalence, well-documented chronic effects, and public health burden. 1,4-BD is toxic (especially acutely or in combination), but not a comparable driver of widespread liver disease.
This was like a last question, “It occurs endogenously or not?”, and that’s what it answered, mentioning some studies.
New England Journal of Medicine:
“1,4-Butanediol and γ-hydroxybutyrate occur endogenously in humans in trace amounts.1”
I wonder if I’d have problems using 4ml twice per night (around 2 or 3 times a week). The one time I took 4.2ml I was knocked out and slept for 6 hours.
This source mentions liver, kidneys and heart (myocarditis) damage but these were people using up to 100-150ml a day:
Consequences of 1,4-Butanediol Misuse: A Review
“Typical complications include toxic hepatitis, nephritis and myocarditis, persistent increase in intracranial pressure.2 The frequency of drug use can reach 20–40 times per day, and the daily dose may increase up to 100–150 ml.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC10698855/
I simply can’t stand not sleeping well anymore, insomnia drugs don’t work for me (even tried Dayvigo, terrible), antipsychotics I can only use for up to 4 days in a row cause they absolutely destroy me psychologically, mirtazapine doesn’t really work. So I might try 1,4 BD again for sleep.
And I have BFS (fasciculation syndrome) and it’s all linked to sleep. If I had access to Xywav I’d have had my life back for a while now. The corruption on the price is absurd. My doctors can prescribe it for me but the problem is the price because it has to be imported to my country.
I’ve been taking 40mg right before sleep cause that’s the dose that is effective for making me stop waking up during the night.
Problem is I have BFS (fasciculation syndrome) and it’s linked to sleep deprivation and poor sleep. So now I need to sleep at an optimal time (early) and for enough hours.
So baclofen has been amazing in making me not wake up during the night, cause when I sleep really early, that’s when I wake up in the middle of the night with no sleep at all. But with baclofen that’s not happening.
Throughout the years suffering from this terrible disease I noticed that I need to sleep early and for 9 hours or even more to start feeling better.
The problem is that many times I was able to do that with baclofen + sleep medication but still wake up with fasciculations.
So maybe that’s the baclofen messing with my REM? Cause I read that at higher doses it can do that. I tried lower doses like 20mg/30mg but unfortunately I wake up in the middle of the night with no sleep.
What’s your experiences with higher doses for sleep? I maybe wanna try taking a 60 or 80mg dose one night so I can maybe sleep the most possible and sleep like a rock but I’m worried it’s gonna be even worse for my sleep quality (REM).
So I’ve been using Baclofen at 40mg at bed time so I don’t wake up in the middle of the night and lose sleep and it’s been working great at that. Some nights I’m sleeping up to 9 hours straight.
The problem is that I’m worried about my REM sleep cause I read that at higher doses Baclofen might reduce REM duration. And I have BFS (fasciculation syndrome) and it’s linked to sleep deprivation and poor sleep and I need the best sleep possible, which is early and for enough hours to start getting better.
And I’m noticing that even though I’m sleeping very early and for enough hours (9), I’m still waking up with fasciculations. So Baclofen is helping with reducing the sleep fragmentation but probably not helping with the overall quality of sleep.
So I’m thinking about switching to pregabalin or gabapentin. The problem is that I use these drugs for my fasciculations and neuropathic pain (and also for anxiety), so I’m worried that it might stop working for that purpose and it really helps in relieving these symptoms.
But my question is, will pregabalin have some maintained efficacy like Baclofen has for sleep maintenance? Cause I know very well how it loses efficacy if I use it all the time for my symptoms (I focus on using when I really need it, like when I didn’t sleep well).
Does the same apply to sleep, in the sense that it will stop working and I’ll be waking up in the middle of the night? Thanks.