u/Potato_Potato_8447

Anyone else having even more trouble getting a hard-on when standing. Weird shit, I have to lie down beat meat and then on a good day I get 100% erect. Standing gives me 60% size max.

Or is the loss of sexual function a life sentence by now?

For those who successfully use(d) HCG, did the mind–penis connection improve with it? And did the improvements stick after cessation (in case you’ve already stopped)?

Is anyone in the patient community in touch with the people undergoing the chemical castration therapy? I’m curious how they’re doing, I understood they’ve come off the castration medication? And anyone aware what med is used, Relugolix or Lupron if I’m not mistaken?

Anyone experience with taking Cordyceps?

It’s suppose to work on the Leydig cells to produce more test (I’m aware of a certain theory of a certain Dr.). In that sense it seems like a more natural alternative to hcg. Can’t find information on whether it is an 5-ari or not.

We’re always talking about androgen signaling and never about estrogen signaling. Anyone with knowledge about this? The estrogen receptor obviously cross-talks with the androgen receptor so we can’t talk about AR signaling in isolation but it feels like we do?

Why my question: I’m seeing a functional doctor who is theorizing pfs shares a lot similarities with hyperestrogenism. But frankly, that’s just well-intentioned speculation.

Hi Dr., a few questions regarding the PFS theory.

When I started finasteride, I got anorgasmia after just one dose. I didn’t know anything about PFS, so I thought it was just an adjustment period. My ability to feel orgasms returned the same day. Although I later developed PFS with many side effects, the anorgasmia fortunately never returned. Does your theory explain this phenomenon?

Another question, is it possible that we have structurally impaired our ability to excrete androgens? That would imply that even on Lupron or Relugolix (not sure which one was preferred) we still wouldn’t be able to properly clear the metabolic waste?

I wonder if there are patients here taking calcium d-glucarate. If so, what are your experiences?

Anyone aware about this new device and the progress of clinical testing? Seems promising for ED

https://comphya.com/caverstim

So I’ve been reading on this sub that there’s a lot of reason for hope. In the comments, I asked what new developments there actually are, but I haven’t gotten a clear answer. Are there any new initiatives that genuinely justify this optimism?

Concretely, we have the PFSN studies on the background, but it’s unclear what they will yield. There’s also Dr. Powers’ theory, which still needs proper research to even get off the ground. The proposed castration-based therapy sounds very risky. Status of Melcangi’s research is unclear to me, and his suggested treatment with zuranolone has unfortunately already been tried without success. My humble opinion, these 3 ‘projects’ each, do not seem te be anywhere near safe and reproducible treatment for pfs.

Given all the optimism I’m reading here, I’m wondering if I’m missing any other initiatives beyond these three?

Hello doctor, nice seeing a message on X with you at the PFS conference. Looking forward to hear about an update and hopefully new insights from your work on understanding PFS.

Keep going!

https://x.com/pfsfoundation/status/2047843486007697412?s=46

I read somewhere there is a PFS conference this weekend, can’t find any information on this. Anyone attending? Where can I find info about this event?