u/LaruePDX

am I the only so bad that I can’t tolerate any meds or supplements.

what test should I consider before considering a protocol. I’m a severe long hauler w PFS/PSSD. Thenk you i am looking forward to more information coming out from the patients going through Castration protocol.

I'm monitoring the journey of the patients doing the protocol. I took Fin from 2010-2021. Unfortunately, I btrusted my Dr and the FDA. Within the itsg six months I developed side effects. one of which was severe depression. I didn't suspect Fin as the culprit. I was put on the worst anti depressant possible with Fin-Prozac. took it for 4 years. I am 5 years out and have made every mistake possible as I had no idea bakit the extent of PFS or PSSD. the most debiktaimg aspect for me is joint and soft tissue issues. I made a catastrophic mistake and had hip surgery in 2024.

My body simply did not have the signaling and raw materials to heal. I know my collagen synthesis is fucked. I have so many other symptoms. But, the pain, atrophy and connective tissue destruction is unreal. I also suspecty nine health is poor at best. I awaiting the results and I will most likely turn to the protocol as my Hail Mary. ii was so fucking dumb not to rearxh Fin and Prozac. I am basicall bed ridden and declining.

I was a competitive cyclist and worked in my feet ten hours a day. when I started Fin issues came up quickly in hindsight. My gains in the gym stopped and I started to have mild joint pain. Bla med it on aging and geneics. I was so dumb and ignorant. I believe this protocol has the potential to restore proper metabolic signaling. I hope I not too far gone. I may not be a good candidate and I own the risk. I just can't love like this. I feel like I'merely existing. Idk what I'm asking or looking for. I'm just thankful Dr Powres is trying to save lives of our dismissed community. He is putting himself of forriducle and judgment within his peer group. He could enetualy be recognized as a pioneer in this nightmare. Sorry about the typos my vision is getting worse as well.

does anyone else have severe joint/connective tissue issues? is this a signaling issue. I feel like my ability to heal is fucked. i can’t overcome injurie.

I have severe, longstanding PFS with progressive muscle loss, severe muscle/tendon pain, and major loss of function.

Objective findings:

• Left hip: external-rotator atrophy with tendons scarred to the posterior capsule; gluteal tendon thickening/scar remodeling with fatty infiltration; mild hamstring tendinosis
• Lumbar MRI: abnormal T2 signal/edema in the lower-lumbar paraspinal muscles. The original report called it minimal/nonspecific, but it was subsequently reviewed and I was told the edema appears significant.
• No major implant loosening, fracture, infection, spinal stenosis, or foraminal stenosis.

Recent hormones:

• Total testosterone ~525
• Free testosterone normal
• LH 1.7
• FSH 4.9
• Estradiol ~30

My concern is that I may have normal serum testosterone but impaired tissue-level androgen signaling, potentially contributing to the muscle atrophy, tendon problems, abnormal muscle MRI findings, and poor recovery.

Dr. Powers, could this fit the subgroup you’re describing?

What objective testing would you recommend to determine whether this mechanism is actually present? Would you look at androgen metabolites such as 3α-diol-G/DHT, CK/aldolase, EMG/NCS, additional muscle MRI, or anything else?

Finally, given my findings and severe functional decline, do you think I am someone who should consider attempting the relugolix/chemical-castration reset protocol, or would you recommend establishing additional objective evidence first?

I’m trying to determine whether I may be in the subgroup you believe could benefit from the protocol rather than simply experimenting blindly.

Hello,

i know Dr Powers has patients actively going through a prprofile. does anyone have any of those patients have connective tissue issues. I have severe issues within my pelvis floors Getting an MRI to take a closer look. I have Glute tendonosisi and atrophy. the muscle feels dormant and unresponsive and my lower back has arthritis which could be unrelated to PfS. I guess I’m curious how/if there is any hope for restoring my body’s natural ability to heal. I’m concerned this is also vascular in nature. Where I’m not getting adequate blood and oxygen to the tissue. Could the protocol restore signaling and kick start healing. The rest of my PFS/PSSD symptoms I can learn to live with.

I started at 38 and took it for ten years. I tolerated it ok until I got older. I feel like the severity of PFS could be worse as we age. if I started in my 20’s and quit by 30 I have to believe I would have more capacity to heal.

I keep researching how to heal collagen synthesis and androgen signaling and everything leads back to hormonal balance.i wish it was that fucking easy. this poison has been around since 97’ and we are still being told to get your testo checked. it is so fucked!

i am ready to do some drastic shit. I’m starting conservatively with dry needling and shockwave for tendon scaring But, then looking at peptides.

I have ongoing severe atrophy and damage in the tendons and soft tissue all around my pelvic floor and lower back. I’m one severe pain and have totake action. I’m goimg to start what is known as the Wolverine stack in the peptide community. I know this could go horribly wrong. But, I’m basically crippled as it is.

I need hope…. this is so bad . I have extreme muscle and soft tissue atrophy in my pelivd area. feels like my muscles have shut down. it is just getting worse.

I have tendonosis in my glute min and max. Hamstings… I’m thinking about doing PRP injections. I have to do something.

My connecmotive tissue in my pelvic floor and back is breaking down. The pain is unrelenting, I am ready to try anything. is there anything I do do?!? BPC -157?!? I am scared taking my life is my only option. How the fuck can this be real.

Along with the pharmaceutical companies, Dr’s and prescribers are killing oeople daily. my life was taken the first day I took Fin then when I became depressed that’s when they pit the final final nail in the coffin with anti depressant. I will never heal at all. My body and brain will never heal and they take zero responsibilit.

I know fucked yo androgen signaling has been a huge reason I’m deteriorating.there has to be something that can be done. I have severe bone/nerve and soft tissue issues. there has to be something I can do. I don’t want to fucking die. I just can’t live with this much pain. I can deal with any other part of PFS.

I have what feels like the most severe case possible. I don’t want to kill myself. But, I’ve lost everything and loved line a hermit. if someone told me that in 5 years we like have a transmit that offers meaningful healing. I would be able to hang on. My body and brain are wasting away. All because I could not recognize and connect the side effcets back to this poison.

I feel like I need to completely cut out sugar. after I eat anything I feel my nervous system gets more fucked, brain fog and general inflammation spike.

Hello, I am a 53-year-old male. I let an ortho convince me I needed a hip replacement three years ago. I now realize it was more nerve related and nothing really indicated it was the hip joint. He knew I was desperate to bike, snowboard, and do yoga. He told me if I wanted to bike again I needed to do this. Soon after surgery I started to get groin pain and knew something was wrong. I kept getting gaslit that I would heal. My brain wanted to believe I would just get better. PT just made the pain worse. this last holiday I became so dispodant that I OD’d on oain meds, passed out and was hospitalized. I just want my life back. This is what was found in the MRI and my suregeim wants nothing to do with me now:

• Iliopsoas close to the acetabular cup → possible groin pain/hip flexor irritation.
• Gluteal tendons thickened/scar remodeled → possible side hip/upper glute pain.
• Mild fatty infiltration of glute muscles → some muscle loss/weakness.
• External rotator muscle atrophy + scarring → altered hip mechanics, possible pain.
• Mild hamstring tendinosis → possible buttock discomfort

I realize virtually no one has these issues. I don't know where to turn. I don't want another surgery. I ha e constant pain and can't do this much longer.