Having Leslie obsessed with the Duprees for no reason is tired. Her beef should end at Ted and Bill.
There should've been something to make Leslie actually hate this family. Barbara not wanting her isn't Anita's fault. Ted not wanting her isn't Nicole's fault. Not to mention, she now has endless pockets because of Anita. Girl what else do you want?
You know what would've been soapy......
Nicole had fertility issues. Ted had an affair with Leslie, but instead of paying Leslie to abort and leave town, he has her kidnapped and gives her baby to Nicole. Nicole unknowingly adopts Ted's affair baby, and raises the baby as her own. Ted and Bill have had Leslie locked up in a asylum all these years, but she breaks out ready for revenge. Leslie's beef could've been the Duprees not giving her access to her daughter even after finding out the truth.
Or if you really want to get soapy...... Have Nicole find out about the affair and have her be the one to lock Leslie up and steal her baby.
Bonus points: Anita could've always knew about Leslie being Barbara's daughter and took her in as a niece. Leslie pulls a cousin Faith and sleeps with Ted. Anita chooses her real family over Leslie and has her locked up in the loonie bin, and they raise Katherine Evangeline as a Dupree.