u/NourEldin_

I am an early carer researcher, currently at medical school, and I have a really big paper with great potential, unfortunately I can't afford to publish it open access, and sometimes my abstract get accepted in International conferences, still I can't afford travelling and accommodation fees :(

I am an early carer researcher, currently at medical school, and I have a really big paper with great potential, unfortunately I can't afford to publish it open access, and sometimes my abstract get accepted in International conferences, still I can't afford travelling and accommodation fees :(

I am an early carer researcher, currently at medical school, and I have a really big paper with great potential, unfortunately I can't afford to publish it open access, and sometimes my abstract get accepted in International conferences, still I can't afford travelling and accommodation fees :(

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Hello everyone,

My colleagues and I recently published a review article in Regenerative Engineering and Translational Medicine* titled :

"The Use of Organoids in Dentistry: An Overview of New Research Approaches"

I wanted to share a summary of our findings with this community, as this technology is poised to shift our approach from traditional restorative materials toward true biological regeneration.

For those unfamiliar, organoids are miniature, three-dimensional, self-organizing structures derived from stem cells that accurately mimic the architecture and functionality of human native tissues. Unlike traditional 2D cell cultures, which fail to capture complex cellular interplay, or animal models, which don't always translate perfectly to human physiology, organoids give us a highly accurate in vitro system.

Here are the key areas where organoids are making waves in dental science:

1. Tooth and Periodontal Tissue Regeneration

Traditional dental research heavily relies on animal models, but tooth organoids—typically cultivated using stem cells like Dental Pulp Stem Cells (DPSCs) and Periodontal Ligament Stem Cells (PDLSCs)—are filling the gap.

* They allow us to model complex conditions like pulpitis, apical periodontitis, and dental caries.

* We are seeing massive potential for tissue engineering; rather than relying solely on implants or grafts, organoids could eventually help regenerate missing teeth, cementum, and alveolar bone by utilizing the body's innate regenerative capacity.

2. Restoring Salivary Gland Function

Irreversible damage to salivary glands from radiation therapy or autoimmune diseases like Sjögren’s syndrome (resulting in severe xerostomia) is notoriously difficult to manage.

* Researchers are successfully developing salivary gland organoids containing functional acinar and ductal cells.

* These models have actually demonstrated the ability to produce saliva in response to neurotransmitter stimulation and have restored glandular function when transplanted in animal models.

3. Precision Oncology for Oral Cancers

Oral squamous cell carcinoma (OSCC) and other oral malignancies exhibit vast genetic diversity that traditional models struggle to replicate.

* Patient-derived tumor organoids can preserve the original tumor's exact morphological and immunophenotypic characteristics.

* This allows clinicians to test chemotherapeutic and radiotherapeutic interventions directly on the patient's specific cancer organoid to predict therapeutic responses before treating the actual patient.

We're incredibly excited about the future of this bioengineering frontier. If you are interested in the deep dive, including the exact signaling pathways and biomaterial scaffolds used, you can check out the full paper here:

https://doi.org/10.1007/s40883-025-00541-7.

I would love to hear your thoughts on this! Do you see biological tissue regeneration becoming a standard in your practices within our lifetimes?