u/Ok-Arm-8127

hi, i wonder if anyone else has experienced malate as being sedative.I have mthfr - homozygous slow comt and VDR taq. I am trying to to get up to 360 mgs of elemental magnesium through malate. i have tried different times, dissolving in h20 and loading am and pm , but it sedates me, i was floored by other forms of magnesium.I am also on clomipramine 70 mgs for an episode of depression, has anyone else found malate sedating? i presume its the MG acting on GABA and maybe i should reduce dose and build up, any thoughts or advice appreciated 👍