Schaden häufige Diäten dem Stoffwechsel? Eine aktuelle Analyse
Wenn man bei der Abnahme ein hartnäckiges Plateau erreicht hat oder im Zielgewicht angekommen ist, fragen sich viele, ob der Stoffwechsel aufgrund vorheriger Diäten oder durch die Art der Abnahme „kaputt“ gegangen sein könnte.
In einer umfangreichen Analyse haben sich zwei Wissenschaftler diesem Thema angenommen und in der aktuellen Juni Ausgabe The Lancet Diabetes & Endocrinolgy Is weight cycling clinically harmfull? dazu Stellung genommen. Die Autoren gehen auch auf eine Abnahme unter Mounjaro ein.
Ihr Fazit: Das meiste ist im Bereich von Mythen angesiedelt und nicht durch robuste wissenschaftliche Daten untermauert (auch wenn selbst in Fachpublikationen häufig so getan würde, als ob).
Leider ist der Artikel hinter einer Bezahlfunktion, man findet aber gute Zusammenfassungen im Netz. Hier die relevanten Punkte aus der Originalarbeit.
Myths and realities about weight cycling
Increased bodyweight and fatmass?
Final bodyweight and fat mass after weight cycling will likely be the same or lower than those a patient with obesity started from. Gradually rising bodyweight over a patient’s lifetime is not consistently related to weight cycling history and is independent of baseline adiposity status, which implicates ageing.
Decreased lean (muscle) mass?
The effect of weight cycling on lean mass will depend both on the final bodyweight attained, and on the diet and physical activity patterns during the phases of weight loss and regain. No robust evidence currently exists to suggest that weight cycling per se causes disproportionally low lean mass.
Lower resting metabolic rate?
Resting metabolic rate after weight cycling is on the order of what would be anticipated for the final bodyweight and body composition achieved.
More widespread metabolic abnormalities?
Weight cycling does not seem to exacerbate the metabolic complications of obesity. If anything, some benefit can be realised, particularly if the final bodyweight is lower than the starting weight.
Adverse alterations in immune function and inflammation?
There is evidence of both harmful and beneficial effects of weight cycling at the cellular or tissue levels, but their functional significance is unclear as global metabolic homeostasis remains largely unaffected.
More visceral and ectopic fat deposition (eg, liver, muscle, pancreas, and heart)?
Weight cycling does not promote fat accumulation in the liver, but data on visceral adipose tissue and other ectopic fat depots are scarce. There is a need for more research.
Increased risk of cardiometabolic disease and mortality?
Such reports are likely due to reverse causation or confounding from underlying metabolic dysfunction or pre-existing ill health.
Frustration and disappointment? Feelings of frustration and disappointment are not a myth. However, weight cycling is a hurdle in nearly every successful weight loss journey.