u/OperationKindly2794

I started my eczema treatment journey about a year ago with Baricitinib. The first 5 months were amazing, my skin improved more than I thought was possible.

After that, things started getting a bit worse. Still much better than before treatment, but not as good as those first few months.

My dermatologist convinced me to switch to Tralokinumab. The 2–3 weeks off baricitinib were awful and I basically flared back to square one. Now I’ve been on tralokinumab for 3 months and I’m still nowhere near the results I had with baricitinib, I would say close to no results whatsoever.

Has anyone had little or no success with tralokinumab but responded well to dupilumab? Is it worth a shot? Or would you go back to a JAK inhibitor in this situation?

Sidenote: also had alopecia areata in the past.

Im a qd with ~1 yoe, let’s say second tier firm and quite small desk, whats the best way to get a big bonus even early in your career?

Feels like the really big bonuses are reserved for traders and researchers, what would you do to maximize your personal total comp as a dev in a desk?

I have ~1 yoe so still not a lot of experience in the industry