u/Overall_Antelope_504

Over the years, I've been dealing with a wide range of symptoms that doctors haven't been able to identify. I was diagnosed with Crohn’s disease in 2018, mild Gastroparesis in 2023—which occurred right after stopping a long course of prednisone—and POTS in 2025, even though I had been experiencing symptoms since I finished the prednisone. Nobody has questioned my cortisol levels, even though I've mentioned it multiple times. I'm underweight, can't gain weight, dizzy, have migraines often and always feel nauseous, but lately I can't get my nervous system under control. I can't seem to calm my body down whenever anything stressful happens. I'm not asking if this is AI but whether anyone has been through something similar?

So far I've been on Humira, Entyvio, Stelara, Rinvoq, and now skyrizi. Currently, Skyrizi isn't keeping me in remission and my inflammation is pretty high like 8,000. My doctor wants me on budesonide until I can get on a new biologic but it makes me so nauseous and increases my migraines. I don't have diarrhea I have constipation and urgency at times. Does budesonide make anyone else feel worse?

My MIL, who is 73, has had RA, osteoarthritis, and osteoporosis for the majority of her life. She has been on methotrexate, Humira, Orencia, and prednisone. She is currently taking leflunomide and Rinvoq. She has a history of high BP and has a pacemaker. Her rheumatologist knew this before prescribing Rinvoq. She's been on Rinvoq for a month and is now experiencing high BP even with taking BP meds. Is that a common side effect?

I would describe it as feeling poisoned. It has significantly impacted my health, especially my head and gut. I constantly feel like I have motion sickness, nausea, and memory loss. I've been exposed to mold for 2 1/2 years and have been the most affected among us. I am underweight and unable to gain weight. We're finally moving into a new home, but I'm worried about reinfection because my family refuses to replace the porous items that can be replaced.

I was diagnosed with IC a few years ago, and I've noticed that my symptoms tend to worsen around my period. I often struggle to determine whether it's a UTI. I've visited my primary care provider multiple times about it. Sometimes, it feels like my kidneys are affected, so a UTI could be the cause, but I'm tired of taking antibiotics every time this happens. I already got CDiff this year from being on antibiotics twice for a UTI last year.