u/PA9912

I was put on an off label drug for adhd that is a basically a norepinephrine and dopamine reputake inhibitor. It works in a similar way to Wellbutrin but is quite strong…in fact it’s used for narcolepsy too. The issue is that it feels like it’s tanking my cortisol. I have taken pain meds with no issue and I doubt dopamine is the cause but norepinephrine is basically adrenaline. Other drugs that increase this are stimulants like Ritalin, concerta etc.

Has anyone experienced this issue? My cortisol seems low every afternoon now. I did a search and it seems like some people take adhd meds without issue but I can’t think of another reason this is happening. I’m also secondary in case that’s helpful to know. Things like caffeine actually do help me a little when my cortisol is low.

My endo has been no help and my PCP is clueless. As usual. And doctors never consider my adrenal issues when prescribing unfortunately. I didn’t even know there were drugs that lower hydro efficacy until recently.

I was really excited to start cromolyn and was hoping to alternate it with ketotifen to reduce tolerance which I get from all meds but Xolair. The issue is that after the first week it doesn’t work nearly as well, even for GI symptoms. It’s barely helpful now and I started skin flushing again even after taking it. I also read it doesn’t cross the blood brain barrier which I find helpful about ketotifen. I also don’t find the eye drops or nasal spray very helpful.

Has anyone felt this way? I don’t react to it; it just doesn’t work well. My biggest allergy is salicylates in case that’s related at all. For example, I can’t do DAO from peas or quercetin.