Stimulants + cholinergics?
Have you tried taking something that raises dopamine/noradrenaline alongside something that raises Acetylcholine? If so, what was your experience (mood, motivation, focus, mental clarity)? Is it a good combination?
Have you tried taking something that raises dopamine/noradrenaline alongside something that raises Acetylcholine? If so, what was your experience (mood, motivation, focus, mental clarity)? Is it a good combination?
Do things that increase Dopamine/noradrenaline synergize well with things that increase Acetylcholine? what's your experience (Focus, motivation, mental clarity)?
Every stimulant i've tried had a similar effect on me: They make me wired and increase my vigiliance, kinda improve my attention and sometimes i felt like my muscles were ready to run or fight. But that's about it
I get 0 of the anticipatory excitement/motivational effects from them, i don't get any more enjoyment with them or make me actually feel interested in doing things for the "grand scheme" long term goals or even for stuff like seeking social interactions. In fact i'd argue amphetamine/dextroamphetamine actually made me less interested (mainly because it also happened to blunt enjoyment for leisure activities like watching tv shows while doing nothing for motivation), whereas with methylphenidate it has 0 positive or negative effect on mood and it just simply makes me wired.
They give me more willpower to keep grinding, but the effort in the process feels mechanical and i feel like i just do things for inertia, i don't get quite into flow state/in the zone either. I mean, i can keep going but it would be nice if at least i felt SOME sort of motivation or anticipatory excitement at all. Motivation acts as a catalyst for longer term goals, on the very rare moments where i get motivated for stuff that is not watching some movies or playing some games (it happened during the very first week of methylphenidate but i know its common for that initial feeling not to last) it's like i just get more ideas about how to achieve goals and put them into execution more quickly and with better organization and planification than if i was just trying to willpower my way through it
The reason i say adrenergic effects without dopaminergic ones is because i remember not a long time ago i took a preworkout (without the meds) that had synephrine and yohimbine among other stuff like caffeine and those are compounds that affect noradrenaline way more than dopamine, and it honestly made me feel very similar from stimulants that supposedly have a more balanced effect between the 2 in that it made me feel wired and alert without much else going on
If you placebo-blinded me, i would be able to tell the difference between pill and no pill but i think i wouldnt notice the difference if you gave me amphetamines or that preworkout or methylphenidate, i would simply feel more alert and think a bit faster/concentrate longer.
Does anybody else have a similar experience to me in that stimulants provide 0 positive effects in mood and motivation? Has anybody found something that made them feel a bit more motivated or interested about things? Im not wondering about euphoria, i dont need that, but i guess something that made you feel a bit more enthusiastic and in general feel more enjoyment from things, if anything made you feel that way what was it?