u/PrintConfident8417

I did an OGTT with insulin test - my blood sugar went really high at the 1hr mark (in T2 diabetes range). It then came into pre-diabetic range at the 2hr mark. However, my insulin remained super high throughout the test (more than double the reference range amount). This caused my blood sugar to drop rapidly after I left the clinic causing me to go hypoglycemic.

It was so scary, I couldn’t talk or think and my sister had to feed me a banana/juice to get my glucose back up.

Is this common and has anyone else experienced this? I try to limit carbs and sugar so I haven’t had that much sugar since I was a kid - and nothing like this has ever happened to me before.

For context, I have lean PCOS. No other confirmed diagnosis (which is why I did this test). My fasting insulin is very low (below reference range) so I suspect I have an impaired first phase insulin release which causes the high glucose spikes initially.

I’ve smelled several people wearing a perfume that almost smells like a blue raspberry popsicle- that’s fun, fruity and fresh (and slightly tart), but I’ve never had the courage to ask any of them what they’re wearing. Any ideas?

It’s perfect for summertime.

It almost smells like it would be a body mist, but the projection (and quality) is so good that makes me wonder if it’s an actual perfume.

I’ve smelled a handful of people wearing it over the last 7+ years.

I was doing some reading and was presented with the theory (by AI, so take it with a grain of salt) that people who are hyper mobile have a harder time adjusting to cromolyn. Does anyone know if there’s any truth to this? Or have people who are hyper mobile or have EDS been able to tolerate cromolyn easily - and are taking full doses?

I just switched from capsules to the liquid form and it was delivered with an ice pack.

But it doesn’t say anything about needing refrigeration on the bottle and the pharmacy is now closed. Does this medication need to be kept cold?

It’s not the ampules. It’s in a large bottle I have to draw up with a syringe.

I’m experiencing a mini flare that has brought on new joint pain. But I have no idea what it could be from.

I started cromolyn about 5 days ago but I’m taking a super-micro dose. Literally 1/25th of a dose. I’ve reacted to a full dose before, but with brain fog and head pressure- so this feels different.

I’ve also introduced magnesium malate, ovasitol (a form of inositol) and I took a single probiotic cap 4 days ago (histaminX brand).

Has anyone reacted to any of these before?

I’m really hoping that it’s not the cromolyn. I want it to work so badly… and it’s literally such a tiny dose.

Just feeling defeated and stressed.

I felt terrible on my first dose of cromolyn. I got head pressure, a migraine and brain fog. I’m considering lowering the dose and titrating up more slowly - like many people have done. However, I’m curious and wanting to understand what is actually happening that makes people feel worse on it initially, and sometimes long term. What is its mechanism for stabilizing mast cells and why do some people feel worse?

Is it actually causing further mast cell degranulation?

Anything that makes me feel unwell makes me incredibly anxious… since I actually caused my MCAS by “pushing through” side effects/symptoms that I thought were temporary, but would eventually result in gut healing.

So are these side effects something that is worth it in the end, or could they actually be making our MCAS much worse in the long run?

I’m so desperate at this point and looking for any suggestions and guidance you can share.

I didn’t get much instruction from my practitioner regarding starting chromolyn. I took my first dose today - taken 30min before dinner.

I have the capsules, but she said I could open them and mix it into water so it will coat the inside of my stomach (which is where we want to target).

After my first dose (a full capsule), I began feeling agitated, uncomfortable, foggy and got head pressure. Which are common symptoms I get when exposed to an irritant, etc.

So… is this normal? Am I supposed to build up tolerance gradually? Will my body adjust or is this a surefire sign that I should quit while I’m ahead before it puts me into a flare?

For reference, I have slow MAO and COMT genes meaning that I clear neurotransmitters and toxins slowly. Which is why I can’t tolerate things like LDN. So I’m just wondering if this is something that could build up in my system like that, or if my cells just need time to adjust gradually.

I tolerated Ketotifen really well so I’ve been surprised by this reaction.

Other than glucose spikes (which I’m currently managing), I believe that the sole act of digesting my food is my biggest trigger.

No matter how low histamine I eat, or whether I take dao enzymes or not… I seem to itch and my skin becomes inflamed after meals. It has even gotten worse since trying to work on my vagus nerve (for the purpose of improving digestion), which leads me to believe that the release of histamine by the stomach, to produce stomach acid is leading to my mast cell degranulation.

I’ve taken high dose ketotifen for several months without any benefit, because I’ve had an unknown daily trigger that I haven’t been able to identify. I recently started working on the root cause of my poor digestive health and have seen improvements. But while my digestion is better, my MCAS flares got worse.

For context, I developed the same symptoms I’m currently experiencing (puffy face, itchy jaw line, skin is irritated and red) while trying digestive aids like betaine HCL or digestive bitters.

I suspect that the parietal cells which release histamine to produce the stomach acid are causing my mast cells to degranulate systemically. Has anyone else experienced this before? Is this a plausible theory, and if so, have you found a solution?

I know that H2 blockers can help with this, but I’ve been reluctant to try them up until now since I was initially trying to “increase” my stomach acid due to poor gut health and gut dysbiosis. I’m open to it now, if this is in fact the cause of my persistent and daily flares.

Has anyone on Pepcid noticed a significant decrease in stomach acid/digestive capacity, or worsening of gut health since starting the medication?

And has anyone else been triggered by digestive juices/production of stomach acid or enzymes?

Any suggestions are appreciated.

As the title says, I got a headache and felt generally unwell and a bit nauseous after using the device for the first time.

I started with 5min on level 17. I couldn’t feel the pulse too strongly, so I thought this was a safe level.

Then I tried level 20 for 1-2min. Just to compare the level difference.

Shortly after, I developed a headache and nausea. Is this normal, or is this my body saying that it does t tolerate this type of stimulation - as I do have a sensitive system?

Should I try it again on a lower setting, or is this a clear sign to stop altogether?

I’m just concerned about doing unnecessary harm.