
Altitude physiology in critical transport — what changes when your ICU patient leaves the ground
Reposting something I've been meaning to write up after a few months doing critical care air transport alongside ground ICU work.
Most intensivists know the theory. Fewer have felt it in practice at 28,000 feet with a deteriorating patient and a ventilator that's not the one from your unit.
The oxygenation problem is real and underestimated.
Commercial aircraft cabins are pressurised to approximately 6,000–8,000 feet equivalent altitude. Charter aircraft used for medical transport are similar. At that pressure, FiO2 from your 100% oxygen source still delivers 100% - but the partial pressure of inspired oxygen (PiO2) drops by roughly 20–25% compared to sea level.
For a patient with healthy lungs, inconsequential. For a patient with:
- ARDS on high FiO2 with marginal SpO2
- Severe pneumonia
- Post-lobectomy or post-transplant lungs
- Pulmonary hypertension
...that drop is not trivial. I've seen patients who looked stable at ground level show SpO2 dips within 20 minutes of reaching cruise altitude, requiring FiO2 escalation we hadn't budgeted for in our oxygen reserve calculations.
The ventilator switch problem nobody talks about.
Patients arrive from ICUs on specific ventilators — often Draeger, Hamilton, Maquet. Transport ventilators are a different beast. Volume-pressure relationships behave differently. Trigger sensitivity varies. If your patient has been on a specific mode and PEEP for 48 hours and you switch devices 10 minutes before loading onto an aircraft, you will spend the first 30 minutes of the flight chasing settings.
Best practice I've landed on: if at all possible, do the ventilator transition at the referring ICU while the team is still present and you have backup. Don't do it on the tarmac.
The moments that actually scare me - and it's not the flight.
In order of actual clinical risk in my experience:
- Stretcher transfer (position change + vibration triggers haemodynamic shifts you don't expect)
- Ground ambulance to aircraft loading — ambient temperature, altitude already rising, family chaos around you
- Cruise altitude FiO2 recalculation
- Destination transfer - everyone relaxes too early
The flight itself, if the patient is appropriately stabilised, is usually the most controlled phase. The transitions are where things go wrong.