ACOU085: Promising First-in-Patient Results in Cisplatin-Induced Ototoxicity

>In patients who developed ototoxicity, treatment with ACOU085 resulted in a clinically meaningful prevention of pure-tone audiometry (PTA) threshold increases at affected frequencies, compared to placebo, following the final cisplatin cycle. Further analysis of the PROHEAR Study results, including post-hoc evaluations, is ongoing and will be submitted for publication in a peer-reviewed journal.

>“This is an important and encouraging milestone toward establishing Kv7.4 activation as a novel therapeutic approach for multiple forms of hearing loss. This broad therapeutic potential addresses a significant unmet medical need, which current device-based solutions only partially meet. The clinical results for ACOU085 create a compelling opportunity to advance Kv7.4 modulation into broader patient populations,” said Professor Hubert Löwenheim, Chair of Otorhinolaryngology – Head & Neck Surgery at Tübingen University Medical Center and Scientific Supervisor of the PROHEAR Study.

Although only for cisplatin-Induced hearing loss, it's nice to have some good news once in a while.

acousia.com
u/Repa24 — 5 days ago

Verzögerung bei der Deutschen Bahn: Eröffnung der Bahnstrecke Nürnberg–Regensburg auf Ende Juli verschoben

spiegel.de
u/Repa24 — 1 month ago