Trying Something Different

I really hope Rennie and the coaching team try something different with this team this week.

I'd rather see us take some risks with selections, try different combinations, experiment a little with the tactics, and lose by 20, than try the same thing again and lose by 3.

Obviously we want to win every game if we can, but I don't think doing the same thing again this week is going to give us the best chance.

Taylor out. Parker or Jacobson out (or both). Vaa'i back to 6 with a new locking combo? Blackadder in. Tavatavanawai in. Narawa in. Maybe Rieko? As incredible as he is, Jordan looks like he needs a rest (maybe just a shorter shift?)

Could even try out a new fullback/fly half combo... not sure if Mounga is the answer, but could be worth a go. Love to the back with Mounga at 10? Mackenzie to come off the bench? J Barrett at fullback and Ioane at 13 with Tupaea at 12, or Big Jim at 12 and Tupaea still 13? Then move Barrett in to 12 with Mackenzie coming off the bench?

Definitely need better use of the bench, no matter what the selections are.

Just spitblling here, but we have so many interesting options that could surprise the Boks. I hope we aren't too conservative.

reddit.com
u/Responsible-Quote717 — 1 month ago
🔥 Hot ▲ 26.4k r/DrugsProTips+2 crossposts

In 2015 a woman accidentally snorted 55 mg of pure LSD (equal to 550x a normal recreational dose), thinking it was cocaine. She "blacked out" for the first 12 hours & felt "pleasantly high" for the second 12. A day later her chronic foot pain ceased, leading her to eventually end her morphine habit.

>According to the study, which was published last month by Mark Haden and Birgitta Woods, the 46-year-old woman overdosed on the hallucinogenic drug in 2015 after mistaking it for 55 milligrams of cocaine, CNN reported.
The LSD (lysergic acid diethylamide) was in powder form. The recommended dose (although it is illegal in the U.S. and U.K.) for recreational use is 100 micrograms.
After taking the drug, the woman, referred to as CB in the text, blacked out and vomited for 12 hours straight, CNN reported.
After that, CB recalled feeling "pleasantly high" for the 12 hours that followed, despite still vomiting.
According to the study, CB's roommate recalled the 46-year-old sitting still in a chair, while tripping, with her eyes open or rolled back. She occasionally spoke, but what she said was not understandable.
Just 10 hours after that, CB was "coherent" and was back to holding conversations as normal.
However, it wasn't until the next day that CB noticed a change in her body.
During her 20s, CB was diagnosed with Lyme disease, a condition that badly damaged her foot and caused her to go through life with "significant pain," the study revealed, CNN reported.
After her LSD trip, CB realized her foot pain was gone and she was able to stop using morphine. The pain later returned, but she was able to keep it under control with a lower dose of morphine and a micro dose of LSD every three days.
By January 2018, CB was able to stop taking both morphine and LSD completely and had no withdrawals, the study stated, CNN reported.
While her pain disappeared, CB said she instead experienced anxiety, depression and social withdrawal, according to the study.

u/Pantyprincesss11 — 1 month ago
▲ 64 r/DTIC

All eyes on psychedelic drugmakers as Definium, Compass near major catalysts - BioSpace

"Now, the biotech—formerly known as MindMed—plans to share anxiety data this week, findings that could push Definium’s stock up “25-50% or more,” Jefferies analysts wrote in a Thursday note."

🤑🚀

biospace.com
u/Responsible-Quote717 — 2 months ago
▲ 27 r/DTIC

How Priced-In Are The GAD Results?

With the GAD results due this week, I assume we're all expecting similar results to what we got with the Phase 2b trial and the MDD results from June.

But, how priced-in do you think these results are already? What sort of price movement are we expecting after the results drop? Any guesses?

Good luck and Godspeed. 🚀

reddit.com
u/Responsible-Quote717 — 2 months ago
▲ 922 r/DTIC+1 crossposts

New research finds a single dose of LSD lowers stress and improves problem solving ability, but not in the way scientists expected. The effects showed up a week after the drug wore off

Most of the research on LSD focuses on the experience itself: what people see, feel, and think while the drug is active. The hours during the trip are treated as the event. What comes after is treated as the aftermath, a return to normal.

A new study from the University of Fribourg asked a different question. Instead of measuring what LSD does while people are on it, researchers waited. They gave 45 healthy adults a full clinical dose and sent them home. They did not test them that day.

One week later, participants came back. The researchers measured their stress levels using validated psychological scales. They measured their ability to generate alternative solutions to difficult problems, a core component of cognitive flexibility. They ran motor learning tests. They took brain measurements.

What they found in that one-week window was not what most people would expect from a drug that had finished working six days earlier.

tech-paper.com
u/Responsible-Quote717 — 3 months ago

Definium Therapeutics Gains

Just wanted to share my gains this week after my main holding Definium Therapeutics (DFTX) announced highly (and I mean highly) positive results from their first Phase III trial of LSD for Major Depressive Disorder.

They're set to release two further lots of results from two other Phase III trials of DT120 (their patented form of LSD) for Generalised Anxiety Disorder later on this year.

Up $85k NZD... It's been a very good week.

Anyone else invested in this, or any other psychedelic stocks?

u/Responsible-Quote717 — 4 months ago
▲ 13 r/DTIC

Who's buying?

There's been a lot of comments about profit selling, but who out there is buying at the moment?

If you're planning on buying more in the future, what sort of pullback are you looking for as an entry point?

reddit.com
u/Responsible-Quote717 — 4 months ago
▲ 27 r/DTIC

June 11th - First Phase III Results?

So, are we all thinking that June 11th is the date we get out first Phase III results announcement?

Is this the week we've been waiting for for years?

Will we be above $30 by weeks end?

How are we all feeling?

reddit.com
u/Responsible-Quote717 — 4 months ago