u/Robbos2310

So in past research I’ve handled BPC-157, TB500, Selank, Semax, GHK-CU, etc without any major issues during reconstitution. Recently started working with Tesamorelin and have run into some confusing behaviour.

The Tesamorelin is supplied in 20mg lyophilized vials. Based on a lot of discussion online, the research subject was first reconstituted with 2mL bacteriostatic water. Initially everything appeared normal, however after refrigeration the following day the solution had turned into a jelly-like consistency.

Additional bacteriostatic water was then added incrementally and the solution mostly re-dissolved, although not perfectly. Unsure whether this indicates a concentration issue, formulation issue, or instability problem.

After speaking with a few people, it was suggested that Tesamorelin may sometimes require acetic acid solution rather than bacteriostatic water for proper reconstitution. A fresh 20mg vial was therefore reconstituted using 2mL acetic acid solution instead.

This second vial behaved differently and did not gel in the same way, however the resulting solution appeared significantly more irritating/harsh during research application than other peptides previously handled. Post-application there was noticeable localized redness and irritation around the administration site, although it settled down afterwards.

Questions:

- Is the jelly-like behaviour with bacteriostatic water something others have encountered specifically with Tesamorelin?

- Is there a specific type/strength/brand of bacteriostatic water commonly preferred for Tesamorelin research to avoid gelling?

- Does this sound more like a formulation or manufacturing issue?

- If a vial initially gelled with bacteriostatic water but later re-dissolved after adding additional diluent, would most researchers still consider that vial questionable?

So in the past I’ve used BPC-157, TB500, Selank, Semax, GHK-CU, etc with no real issues reconstituting them. I’ve now started trying Tesamorelin and I’ve hit a wall with it.

I have 20mg vials. Read online pretty much everywhere to reconstitute with 2mL of bacteriostatic water, so I did that. Used it that night, put it in the fridge, then the next night the vial had basically turned into jelly. I had no idea what was going on.

I then added a bit more bacteriostatic water and it dissolved again. Added almost another mL total and it mostly dissolved, but still not perfectly. Didn’t really know whether to trust it after that.

Then I got told by a few people that Tesamorelin is supposed to be reconstituted with acetic acid solution instead. So I did a fresh 20mg vial with 2mL acetic acid solution and injected it tonight and holy shit, it burned BAD. Not “slight sting” bad either. Legit thought something had gone wrong when injecting it. It settled down afterwards and now it’s just red/sore around the injection site, but that was enough to make me seriously question continuing with this.

I’ve now got 10 vials total, with 2 effectively already used/testing:

one reconstituted with bacteriostatic water that gelled,

one with acetic acid solution that burned like hell.

Does this sound normal to people who’ve used Tesamorelin? Is there a specific type/strength/brand of bacteriostatic water people use with peptides like Tesamorelin that helps prevent the whole “turning into gel” issue? Or is this more likely a product/formulation issue?

Also, can the original bacteriostatic water vial that I added extra water to later still be usable, or once it’s gone through that weird gel/dissolve process is it basically questionable at that point?