Enclomiphene *HYPER RESPONDER* 12.5mg qd 8 month results + questions
TLDR: 23M 5’10 Raised total T by 1,000 ng/dL and free T by 200 pg/mL in 8 months on enclo 12.5mg once daily but skyrocketed my LH to 33.1 mIU/mL. Do I continue at this dose or halve it?
THE LONG: I started enclomiphene in August 2025 with baseline results at 429 ng/dL total T and 82.5 pg/mL free T. LH at 3.9 mIU/mL and SHBG at 19 nmol/L (I know, low). I was roughly 175 pounds at 5’10 about 2 weeks out from femur reconstruction surgery eating at maintenance and lifting what I could 3-4 times a week. LH and SHBG pointed towards mild hypnogonadism. I took enclomiphene throughout the entire surgery recovery (4 months crutches + 2 months on a cane) to boost recovery. Fast forward to Jan 5 2026 I got bloods again which came back at 817 ng/dL total T and 208.4 pg/mL free T. LH at 7.6 mIU/mL and SHBG at 16 nmol/L. I had gained weight (190 lb) during post surgery reduction in activity. At this point I was very satisfied with the results, my goal was always to get to the higher end of the normal range and exist there. I started cutting weight to get back into shape and from Jan - May lost about 35 pounds (current weight 152 average fasted morning weight). Just got my 8 month bloodwork to see where my hormones were sitting after losing so much mass and quite frankly I’m dumbfounded. May 12 2026 and 1,430 ng/dL total T, 273.7 pg/mL free T, LH 33.1 mIU/mL, SHBG 35 nmol/L. I would conservatively estimate that I’m about 14-15% bodyfat right now compared to likely over 25% at 190lb in Jan. I do legs (PT focused still getting my strength back in the repaired femur) x2 per week and grease the groove style calisthenics training throughout the day most days of the week. I get around 8-10k steps on average and about 120-150 minutes of zone 2 biking a week. Seeing as how my LH is so high, I need some advice on whether to cut my dose in half to get back under 1,000 ng/dL total T to avoid risking leydig cell desensitization (is this even real?). I’m worried that riding this “TRT” level for too long will result in permanent effects despite enclo being a non permanent alternative to TRT. Attached are bloodwork for each stage (baseline, 4 months, 8 months) for proof. Still waiting to get my E2 results back from the most recent bloods, will update post when those come in tomorrow or Wednesday.