u/Stargenie8

My husband might qualify for the SUPRAMe trial In the UK..we are waiting to find out of his blood is HLa positive to be eligible.

Has anyone else had success on this trial? TIL is also an option. How did you decide between these two possibilities.

He is stage four aggressive melanoma. So we are trying to line up a plan b in case targeted treatment stops working. He is braf positive and on enco/ bini for about three months.

He is also dealing with urinary tract infections and joint pain in the ankles which we think are side effects from the targeted treatment.

My husband is stage four aggressive melanoma. Pembro didn't work and he progressed so fast they moved him to targeted therapy and skipped the iplimubab /nivumolab step.

The NHS in the UK won't usually recommend stopping targeted therapy to risk going to ipi/nivo..however they have said that if we request this they will support it for us.

The reason is the risk of the cancer coming back aggressively and not being able to get it under control before the IM kicks in.

We re not sure what to do..curious if anyone else has explored this and found it to work. Or what are the thoughts on here?

We are aware of some trials where they are monitoring ctdna and taking breaks from targeted therapy. Whereby they wait for ctdna to rise before starting back on the therapy..has anyone had success with this?

We are unsure what to do as we know it is a risk to stop but also if the targeted stops working we might be too late do the IM..whereas at the moment his bloods and scans are good so he would be better able to tolerate it potentially.

My husband is stage IV aggressive melanoma. Was stage II and NED in April this year but moved to stage IV very quickly a month later. So we know it is extremely aggressive and was in multiple organs. He was extremely sick very fast.

However, since starting targeted therapy (he is braf+) called encor/ Bini. He is better than in a very long time..we don't have scans back yet as he began it less than three months ago but we are hopeful those will be reassuring.

My question is what can / do people take safely along with targeted therapy to help extend the lifetime of the drug efficacy. We understand it works for many many years for some and not others.

We are thinking of trying selenium. As studies show it can be effective against melanoma. Does it interfere with targeted treatment?

We will stay away from curcumin, we learned it is not safe from his oncologist. However every oncologist we see cannot give a clear answer on any other alternative therapies. Other than recommending exercises.

Does anyone take anything or follow a particular diet or regimen that they think has contributed to longer pfs?

He is in his 40s and we have 3 very young kids.