▲ 7 r/MTHFR

Does anyone have this combo MTHFR/MTRR/COMT? Methylation Bottleneck Paradox as its nickname. Would love to discuss what’s helped you.

MTHFR C677T (Heterozygous)
MTRR A66G (Heterozygous)
COMT G472A (Homozygous Met/Met)

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u/TheLastRonin35 — 1 day ago

Help Getting Accepted

I've been on the "waitlist" for about a year. I have a great job, former NFL player, 6,000 instagram friends. Is it this hard to get on? What am I doing wrong? Happy to pay for someone to help get me accepted.

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u/TheLastRonin35 — 21 days ago
▲ 2.0k r/bigbangtheory+1 crossposts

My Rant...Anyone else completely agree with Raj in Season 5 when he said he misses the "old days" before the girlfriends took over? Should the four single guys era have lasted way longer?

I’m on my 6th rewatch of the show right now and I just watched "The Weekend Vortex" in Season 5 (the episode where they do the 48-hour Star Wars gaming marathon with the sleeping bags on the floor).

At the end of the episode, after the girls storm in, ruin the night, and Penny says "And that’s how a girl makes a scene," Raj drops a line that hits me hard every time. He says he just wanted a weekend like the "old days"—the four of them hanging out and playing video games before everyone got girlfriends.

Honestly? Raj hit the nail on the head. That's exactly how I feel about the whole trajectory of the show.

Seasons 1–3 are by far the best era of the series. As a single guy who loves nerd culture, those early seasons just hit different. The whole vibe of four single, socially awkward geniuses hanging out at the comic shop, playing games, and trying to talk to the girl next door was pure gold. It felt like a true nerd sanctuary.

Also, early Sheldon was so much better. He was arrogant and rigid, sure, but he was an independent adult who just didn't care about social norms. Later on, it feels like the writers turned him into a helpless child who needed constant babysitting.

I get that a show needs character growth to last 12 seasons, and I’m fine with them introducing Amy and Bernadette eventually. But I really wish they would have let that original "old days" dynamic run for 5 or 6 seasons first.

Once the relationships took over permanently, it stopped being a unique show about nerd subculture and just turned into a mainstream sitcom. Instead of the guys fighting over a Lord of the Rings prop or building a time machine, we got endless plots about wedding planning, relationship agreements, and Bernadette constantly nagging Howard to stop doing the fun stuff he loved (honestly, I can’t stand her later on).

Am I the only one who completely agrees with Raj here? How many seasons do you think the original setup should have lasted before they changed it?

u/TheLastRonin35 — 2 months ago