Quick crash course for understanding refrigerants as a commercial installer.
Typical refrigerant :(410-a) requires a pitch back to the compressors for oil return [this is this crux of man made refrigerants], along with an invert at the top of each riser that's the size of the rise, and a trap at the bottom of each riser thats the size of the run.
Glycol :Flows like water, needs to pitch towards coils, typically uses very large lines, no inverts or traps necessary, requires a special solenoid to install per coil.
Co2 :High pressure. Inverts and traps aren't necessary because of the pressure and rapid movement of gas. Needs a ton of check valves, and redundancy to not blow up.
Ammonia :Nah, fuck that shit.