u/Undeadhip

So, my psychiatrist said that i should control inflammation in order to not end up in bad asthenic-apathetic states. I had been thinking that my inflammation is under control because I’ve been taking biologics since 2016 - it actually worked well, I’ve never had acute pain flares since then.

But now I pay attention and I notice that “no bad pain” doesn’t mean “no inflammation”. It looks like it’s still there but in a different shape. I would wake up being very heavy, with different parts of me being “unpleasant”: neck, lower back, lower ribs, biceps, knees. It’s hard to explain what exactly “unpleasant” means, but those places would like a bit hot, kinda softer than usual. The whole body feels “inflamed” and it’s sometimes hard to name exact spots. I would just want to lay down and wait until it goes away.

Sorry for such an explanation, but my question is exactly about that. Maybe you have something similar - how do you describe it?

So I've been diagnosed with the following in psychoneurological department of a hospital (Kyiv, Ukraine):

Organic brain damage with:

• emotional-volitional disorders
• asthenia
• Astheno-apathetic-depressive syndrome
• F-06.8 (ICD-10 code)

The doctors there say it's due the inflammation from my Psoriatic Arthritis, like it's actually a thing that it may affect brain or CNS. I am now prescribed duloxetine 120 mg and pregabalin 300 mg (150x2).

Anyone heard anything about it? Internet says that there is a link but other doctors in the city I've talked to are being kinda dismissive about the idea

Hi. Just for the context: i've been developing for Apple platforms since 2012; worked at MacPaw for 6 years (the developer of CleanMyMac); have been freelancing since 2023 mostly due to health reasons.

I am keeping an eye on this AI thing. I'm working with Codex and Claude. I'm listening to what people say. And what I think is - most of what we've learned and why we've been valuable won't be needed as much. We all know that those tools can code fine. But even code review will become unneeded. Who cares how the code looks if it does what's needed? The code is going to be written by machines and for machines. There will be no need for us to even look at it.

And I am not talking about far future. I am talking about thinking into that direction already - that is, building systems that does all of the work. If we give enough feedback for AI - it could iterate on its solution until it reaches the target, where the target is "all of the existing requirements + new requirements should be met".

In our software engineering world we could verify the all the requirements are met by using some kind of automated testing. But what limits us as iOS/macOS developers - there is no way to cover everything with automated testing. For example - UI tests are flaky and they can't confirm the visuals exactly, i.e. that how the app looks is what's in the design.

I wonder what you guys think, especially seasoned developers? Time to move on from our beloved coding into building infrastructures and systems? Is it even real in iOS/macOS development world?

I feel like daytime is harder for me to get through without getting overwhelmed and exhausted. And in evenings or at nights it feels like there’s just much less weight and pressure - no sunlight, less noises, less internal expectations like “I should be doing something”

Pregabalin helps with some of that, but I’m looking into more management and life hacks. Going to try living through the days in sunglasses, maybe even at home.

Any chance someone has had similar experience? Any suggestions? Thanks!

33M here, diagnosed at 21 years old (2013). Have been having some strange issues since 2019 where I would quickly and often exhaust to the levels I thought I wouldn’t be able to recover from. It wasn’t looking like regular PsA fatigue. First I was thinking it’s some infection inside me that just eats all my energy and strength from the inside. But then around 2022-2023 I came to the conclusion and diagnosis that it’s psychiatric or something like that, not organic.

But then in 2025-2026 I got new diagnosis in Psycho-neurological department of a hospital - that it IS organic. That PsA have affected my Nervous System or/and brain in a way that leads to such syndrome, symptoms. They prescribed Duloxetine and Pregabalin which seem to definitely help. But…

Ultimate it seems that there is nothing that could be done. The CNS/brain have been affected, or are still being affected by the disease.

And it puts strong limits on my days. I can start a day being somewhat rested, but I can’t go far. In order to be alive the whole day I should either pace myself too strictly, or just turn the day into 2 smaller days by taking a nap.

Guess it is what it is now 🤷‍♂️