u/Unique-Public-8594

These five drugs (atovaquone, metformin, doxycycline, niclosamide, and ivermectin) have an extensive, documented human safety record at doses where its anti-cancer mechanism operates. These medications selectively target cancer stem cells (through their metabolic inflexibility) while not targeting normal cells (due to their metabolic flexibility). There is solid evidence that the concern that “we don’t know if it harms healthy cells” is not true - yet not all clinical teams are aware of this.

Not all clinical teams are aware of cancer’s metabolic inflexibility weakness and that we no longer need to use a treatment that defaults to systemic toxicity as the primary mode of cancer treatment. There is currently a gap between what families deserve to know and what they are told.

The approach outlined in Jane’s How to Starve Cancer book has resonated with people who think, correctly, that there was a body of evidence that was not being brought to them.

Jane McLelland continues to push oncologists to look further and deeper.

(In her substack, Jane provides links to 11 studies that prove the safety of these 5 medications.)

If you are near Stowe and get a chance to stop in at Barbarian, a new restaurant (next to the movie theater), their breakfast sandwich is excellent. Ample size, fresh tomato, quality muffin, aoli, hash browns, chive, meat options plus vegetarian sausage. Wow. $19.00 but worth it.

Stowe adds $1.90 Meal & Room tax.

Friendly vibe.

Any road flooding? Trying to make our way to the FIFA/Boston/Foxboro (tomorrow). So we need to push off soon. Traveling by RV. Have seen the warnings. Any feedback as to whether we need to avoid Montpelier and head from Elmore through St Johnsbury instead before going south through Concord NH?

Hi. Thanks in advance for the help!

Do any of you have a suggestion for this problem:

One of the goals of our photography subreddit mod team is to be friendly to new redditors. Though no karma minimum would be untenable for some subreddits, it has worked well in our case.

About 6 months ago, we started using Automoderator to remove content by Lowest CQS redditors (to filter out content from suspicious accounts). We weren’t noticing problems, it just seemed wise in general, potentially doing our part to help protect not only our sub but also other subs and the platform as a whole.

Now we’re questioning how we can best blend these two (CQS filter and no karma minimum). If every new redditor starts out as Lowest CQS, due only to their low karma, then by implementing a CQS filter, we have inadvertently created a karma minimum.

Is it true that all redditors start as Lowest or are no karma accounts sorted into trustworthy and not trustworthy?

Is there a sweet spot that admins are willing to share (20 karma?) above which, any redditor with a Lowest CQS is suspicious activity rather than low karma alone? Is there a karma level that, if content seems positive & authentic, a redditor moves up the ranks to Low CQS?

If we knew that number, we could set our automod CQS to only filter above that level so we don’t have a karma minimum.

I’m not confident that I’ve described this question clearly. Sorry about that.

My hunch is admins are not at liberty to discuss CQS in detail.

Missing the Milky Way. It used to be bold, years ago. I checked last night (clear skies, new/no moon), but couldn’t see it. Any tips?

I searched this sub for similar questions prior to posting. None found.

First, "why post this here in this sub (rather than r/bugs or r/automoderator)?" Answer: an admin directed me here.

Our photography subreddit has Automod code that assigns flairs based on in-sub karma. This flair system serves two purposes for us: for established contributors, it is gamification. For those who are new to our subreddit, a bot (written by one of our incredible mod team members) alerts our (large, outstanding, and devoted) mod team to first-time contributors, creating a To Do List, and our team uses that To Do List to welcome new subreddit contributors with a human-generated/friendly/customized comment - a warm welcome.

It has been working smoothly for years until a couple of weeks ago. I waited a bit to see if it was a one-off. I gave it another week to see if it was a reddit technological glitch that would resolve soon - but it’s still happening. I’ve checked to see if any member of the mod team (unbeknownst to me) edited the Automod code… nope. Automod history shows the latest revision was back in March of this year (when we added flickr filter code).

It is happening at various karma levels (in Automod, each level has separate rule), so it’s not just one rule that is glitching.

In the same time frame, over 80 other posts have been assigned flairs correctly using this same Automod code.

> Update to clarify, the below rule is the format we use but we have 20 different rules of this type, each with a different karma amount and a different flair.

type:  submission
author:
    post_subreddit_karma: "> 2000"
    ~name:  ["name", "name"]
    is_contributor: false
set_flair: ["Master of Simplicity"]
overwrite_flair: true
action: filter
action_reason: "Move to queue - curated sub"
message: |
    A note from the r/MinimalistPhotography subreddit:  Hi \/u/{{author}}, Sorry for the delay.  This is a curated sub.  For that reason, all posts are held for moderator review. Your post may show as removed or deleted - but it's not... it's just been moved over to our queue waiting for moderator review. It may take a bit of time as we discuss and vote on every photo submitted but we try to get right on it.  While you are waiting, **consider leaving a comment** to kickstart conversation on your post - some ideas include what camera equipment you use, your thought process as you were taking the photo, or what you like about the photo.  And, thanks for your patience.
moderators_exempt: true

I’m stumped. Any ideas on this? (And thank you in advance for being helpful)

Examples of missing flairs for reference:

today, “To & Fro flight”: https://www.reddit.com/r/minimalistphotography/comments/1u3m42f/to_fro_flight/

today, “Urban Architecture”: https://www.reddit.com/r/minimalistphotography/comments/1u36i2g/urban_architecture/

today, “Sunny Apartment”: https://www.reddit.com/r/minimalistphotography/comments/1u3s7kk/sunny_apartment/

yesterday, “Bicyclist”: https://www.reddit.com/r/minimalistphotography/comments/1u2rraw/bicyclist/

2 days ago, “Oslo”: https://www.reddit.com/r/minimalistphotography/comments/1u284io/oslo/

3 days ago, “In flight”: https://www.reddit.com/r/minimalistphotography/comments/1u1avnv/in_flight/

3 days ago, “Traffic Cone in Grass”: https://www.reddit.com/r/minimalistphotography/comments/1u1mw1w/traffic_cone_in_grass/

5 days ago, “Man Drinking Tea”: https://www.reddit.com/r/minimalistphotography/comments/1tz83mf/man_drinking_tea/

8 days ago, “Moonscape Overlook”: https://www.reddit.com/r/minimalistphotography/comments/1tx3mze/moonscape_overlook/

11 days ago, (Astronaut’s photo of rivers from space!): https://www.reddit.com/r/minimalistphotography/comments/1tuaxpt/river_reflections/

Drug study: Daraxonrasib.

Lead researcher: Dr. Brian M. Wolpin, Dana-Farber

Starving cancer by blocking a mutated protein that fuels tumor growth in more than 90% of pancreatic cancer cases.

The GLAGOV study showed that evolocumab combined with a statin more effectively lowers cholesterol (36.6 mg/dL in the evolocumab group compared with about 93 mg/dL in the statin-only group). Reduction occurred in 64.3% of patients receiving evolocumab plus statin versus 47.3% in those on statin alone.

source: JAMA, Nicholls, Dec 2016 https://jamanetwork.com/journals/jama/fullarticle/2584184

Summarized version of Jane McLelland’s email today - Jane is a 30-year survivor of stage 4 cancer who developed her own system for guiding treatment that combines traditional treatments with non-traditional treatments:

One cancer treatment (Histotripsy), uses precisely focused ultrasound to create bubbles that form and collapse within a tumor, tearing cells apart at a structural level. There is no heat, no radiation, no cutting. The procedure leaves the surrounding tissue intact and the immune system’s sensing apparatus fully functional. These tumor cells died in a way that primes anti-tumour immunity (not just at the treated tumor site but at distant tumour sites that were never directly treated) rather than simply ending a cell’s life quietly. The immune system has been educated. It knows the target now. It is looking.

For one patient, after 4 months of Histotripsy treatment, her bloodwork showed a CEA of 3.6. ((It had been 1,500.)

Her oncologist was recommending one more round of (high dose) chemotherapy, which is standard.

Standard-dose chemotherapy — the kind delivered at maximum tolerated dose in cycles, with recovery periods between — is one of the most effective tools oncology has developed. An excellent tool, when the timing is right. At maximum tolerated dose, chemotherapy kills rapidly dividing cells without discrimination. It kills cancer cells. It also kills the rapidly dividing immune cells that the histotripsy procedure has just spent its biological energy activating. The immune reaction that histotripsy just strengthened (dendritic, T, and NK cells), all of it is depleted by high-dose chemotherapy. Histotripsy makes an army to fight cancer, chemotherapy, administered at full dose in its wake, reduces it.

Chemotherapy dosing is not simply a dial controlling how much cancer you kill. It controls which biological processes you are running.

The phase immediately following Histotripsy is arguably the most important phase the patient will ever have. Per Jane, at this time, continuous, low-dose chemotherapy is a better choice (typically around 10% of the standard dose, given daily, without the extended rest periods of conventional cycles) rather than high dose chemotherapy.

Four things happen at metronomic doses that simply do not happen at maximum tolerated dose:

• Anti-angiogenic pressure, continuously maintained. Tumours grow blood vessels. They depend on those vessels in a way that normal tissue does not. High-dose chemotherapy suppresses this vascular network during the treatment window — then allows VEGF, the primary pro-angiogenic signal, to rebound during the recovery period between cycles. Metronomic dosing maintains continuous, low-level anti-angiogenic pressure. The rebound does not happen. The vessels do not recover. (Kerbel & Kamen, Nature Reviews Cancer, 2004)

• Selective immune activation, not immune suppression. At 10% of the maximum tolerated dose, chemotherapy does something that full-dose treatment cannot: it preferentially depletes the immunosuppressive cells — regulatory T cells and myeloid-derived suppressor cells — that tumours use to hide from the immune system. It does this while sparing effector CD8+ T cells and NK cells. In a 2009 Nature Medicine study by Ghiringhelli and colleagues involving human patients, metronomic cyclophosphamide at 50mg daily specifically depleted Tregs while preserving the anti-tumour immune response. The immune system was not suppressed. It was improved. (Ghiringhelli et al., Nat Med, 2009)

• Cancer stem cell suppression. This is the one that matters most in the longer view. High-dose chemotherapy kills the rapidly dividing bulk of a tumour very effectively. But slow-cycling cancer stem cells — the cells responsible for regrowth, for late relapse, for the tumours that come back two years after treatment ends — survive it. They are not cycling fast enough to be caught. Metronomic capecitabine (oral 5-FU) has published anti-cancer stem cell activity in colorectal cancer specifically, reducing the CD133+/CD44+ stem cell fraction via the Wnt/survivin axis. Not just killing today’s tumour. Addressing the cells that would build tomorrow’s. (Emmenegger et al., Clin Cancer Res, 2011)

• Quality of life maintained. The toxicity profile of metronomic dosing is fundamentally different. Peripheral neuropathy — the oxaliplatin legacy that many patients carry for months or years — does not accumulate. Myelosuppression is substantially reduced. The patient can eat, fast, supplement, exercise, and continue the metabolic work that forms the backbone of the broader protocol. The treatment becomes something that fits around a life, rather than a life that fits around treatment. That matters.

The important question becomes not whether to do treatment, not whether to fight, but which treatment will be most effective - and high dose chemotherapy is not always the wisest choice. The question is what form of fighting best serves her biology at this particular moment.

Today, in her listserv, Jane talked about the importance of customizing a cancer treatment plan based on the type/category of cancer (and she requested people spread the information).

Jane’s approach isn’t one protocol for all cancers. The correct treatment depends on which type of cancer you have. Consider these two cancer types have different fuels:

• Glycosis cancers, in which the mitochondria are broken and the cancer’s fuel is sugar. Fueling the mitochondria helps fight the cancer.
• Oxidative phosphorylation (OXPHOS) cancers, in which the fuel is fat (a more common type). For this type, helping the mitochondria would be the wrong approach, it would help the cancer grow.

Some examples of OXPHOS cancers:

• Estrogen positive (ER+ Luminal A) breast cancer (the most common breast cancer).
• Prostate cancer
• Follicular lymphoma
• Hodgkin lymphoma
• Chromophobe renal cell carcinoma

Effective tools for each type:

• Glycosis: keto diet, fasting, and block glycosis pharmacologically.
• OXPHOS: Metformin, statins, Atovaquone (antimalarial), and Tigecycline and/or doxycycline (antibiotics).

> Tests used to identify fuel source (sugar vs fat) include “FDG-PET avidity” and LDH.

Tom Seyfried (a respected expert), thinks differently. He does not recommend statins or Metformin as cancer treatment - but Jane explains that Seyfried is basing that on his study of glucose-driven cancers (only), not considering OXPHOS-driven cancers, which are more common.

Help Vermont take over the US in reddit’s new viral game

Thanks to Maryland’s crab army, Maryland is now merged with states up and down the East Coast forming a new region called Crabalachia in honor of Maryland’s crab. This is what we need to do to continue to succeed:

1. UPVOTE: To help Maryland take over the US, UPVOTE this comment by Charlestownie56: “Maryland/Vermont and Oregon take over the country spreading the best beer, weed, and vibes across the entire nation. America reclaims its status as the best country in the world. “. Here’s the link: CLICK HERE

2. UPVOTE this comment by astral_tiddies: “GIVE ME PRESIDENT BERNIE SANDERS OF THE UNITED STATES OF VERMONSTER OR GIVE ME DEATH. Edit: First course on the menu is Megasota 🍽️”** CLICK HERE

3. Then, sort [THIS POST](Top comment deletes a US State #48 : r/geographymemes) by “Top” and DOWNVOTE all comments above the ones you just upvoted.

Backstory:

Each day, around 11a (ET)  the contest starts over when Jfullr92 posts that day’s map and calls it “Top Comment Deletes a US State”. That is the only post that matters. The other posts are banter, funny rivalries that are sometimes hilarious but don’t determine the vote.  

See the most recent here:  link

The following day, Jfullr92 will delete (first one state, now one region) based on which comment (like “Ohio takes over Illinois”) got the most upvotes (using Top Sort) and then post a new map and the game restarts.

One-by-one over 40+ days, states have been conquered.  Only 3 remain. 

It’s time to rally!!!

To help Vermont win the next round:

1. UPVOTE this specific comment by astral_tiddies (which at the time of this writing has 212 upvotes): ”GIVE ME PRESIDENT BERNIE SANDERS OF THE UNITED STATES OF VERMONSTER OR GIVE ME DEATH Edit: First course on the menu is Megasota 🍽️”

2. Then, open that post refreshed USING THIS LINK the defaulg sort is Best BUT CHANGE THE SORT TO “TOP” and DOWNVOTE all comments above the one you just upvoted.

Thanks!

UPDATE: we’re gaining!! Now up to 264.

###To help Vermont win again tomorrow:

###1. UPVOTE this comment: “Hawai’i, (Oregon) comes for your volcanoes. Congratulations on 10% more rainfall and a new flannel wardrobe.” CLICK HERE

###And

###2. DOWNVOTE this comment: “The Great Minnesotan heros Paul Bunyan and Babe the Blue Ox treat themselves to a nice crab dinner. Megasota (Minnesota) takes Crabbalachia (Vermont).” CLICK HERE

Results expected around 11a ET tomorrow on r/geographymemes subreddit, with a title “Top Comment Deletes a US State #48” posted by user Jfullr92.

Some great places that are gone or not the same:

• Hiking Wheeler Mountain (as a spiral)
• East of Eden restaurant
• Bees Knees, Morrisville
• Pottery on Westphal Rd, Elmore
• Tours of Jasper Hill cellar
• Stowe alpine slide
• Fireside restaurant, Stowe
• Tours of the granite quarry
• Dog Mountain before the suicides
• Drive-up story window in Hardwick
• Down Home restaurant, Montpelier
• Circus Smirkus
• Family-friendly Church Street

I’m looking for mod support surrounding the Timestamp Bug.

Questions:

1. Are there other mods that are impacted?

Context: prior to Q1of 2024 (with reddit’s prior version, “New Reddit”), posts in queue awaiting mod approval, once approved, arrived at the top of New Sort, with a timestamp showing the time that content was approved. Excellent.

Now, with the current version of reddit (“shreddit” introduced in Q1 of 2024), posts that are held in queue awaiting mod approval, once approved, arrive lower in New Sort, with a timestamp showing the time that content was posted.

They now appear in New Sort as old/stale/sunken/lower, often lost from view, sequentially ranked according to its posted/old timestamp (not ideal) rather than its approved/current timestamp (ideal). This gives the subreddit a disadvantage. Content appears to be hours old without upvotes, views, nor comments (zero traction) because the post timestamp is shown rather than the approved timestamp. Since ours is a curated subreddit (all photos are removed to queue then voted on by our mod team as to whether they fit our genre), this hurts not only our sub’s visibility/traction but also hurts each contributor, as it puts their content at a disadvantage compared to other posts in a users’ home feeds.

It was previously mentioned that reddit is working on this and, after waiting all of 2025, it might be fixed in 2026 Q1. Now in May, we see huge earnings posted by reddit for Q1, but no fix of the Timestamp Bug. A fix would be greatly appreciated. We’ve been more than patient. To wait over a year for a bug fix seems… not reasonable, not what I would consider “mod support”.

Example: https://www.reddit.com/r/minimalistphotography/s/ulsle7PGYX

- 3:41pm ET (UTC -4) post submitted.
- Discussed by mod team.
- 7:33p approved and arrives (sunken) in New Sort with a time stamp of 3 hours old but no votes and no views. In our sub it shows at the top of New Sort as our newest post but in a users home feed, other more recent posts would bump it down the feed.

History: Previous posts and comments on this topic:

• days ago, ping, comment in Help subreddit Weekly Recap link
• days ago, requested fix, post in Bugs subreddit link
• days ago, in Help subreddit, admin response, comment, indicating a commitment to fix it: link, (though a more recent comment by Opus in a Help sub Weekly Recap was less optimistic).
• days ago, post in ModSupport subreddit: link

Tagging mods who have previously expressed concern:

• u/thepottsy
• u/SampleOfNone
• WolfXemo

Note: Message to this sub also being sent.