u/VolSapiens

Hi all, I’m starting a research-track faculty position in biomedical science at a hospital this fall, and the onboarding process has already started. Before this, I spent 7 years as a postdoc, then moved to industry for 3 years, and now I’m coming back to academia.

I have several naive questions and would really appreciate honest advice from people who’ve been through this process. Please feel free to answer any questions you’re comfortable with.

1. During my chalk talk, I proposed a project with 3 possible specific aims. When is the right time to submit an R01? How much preliminary data is usually expected for a new PI? Does Aim 1 need to be mostly completed, or is a strong proof-of-concept data showing my approach is feasible enough?
2. As a new PI, should I prioritize getting institutional approvals (IACUC, IBC, etc.) before focusing on NIH submissions? Also, for IACUC protocols, is it better to only include the exact scope of the first R01 project, or should I include additional mouse lines, potential target genes and procedures I may work on in the future? Broader umbrella protocols vs. separate protocols for each project?
3. Since I’m building the lab from scratch with a limited startup budget, does it make more sense to first apply for an R21 rather than an R01?
4. I don’t think I qualify for ESI status anymore since I’m >10 years post-PhD. Are there other NIH programs that tend to be more favorable for first-time submitters?
5. What do people think about R35 for a new PI? In what situations does it make more sense to pursue an R35 over a traditional R01?
6. I see many different R01 funding opportunities with different RFA or PAR numbers under the same NIH institute. How do you figure out which one is actually the best fit for your project?
7. When is the best time to start communicating with POs?
8. When is the best time to hire a research associate or postdoc?

Any other advice for a new PI trying to set up a lab, manage timelines, and survive the first few years would be greatly appreciated.