u/allthatjoeydid

▲ 30 r/IVF

Pgt-a not recommended by uk regulator - what’s the medical view in US?

The UK has the most advanced regulator of IVF I think in the world. This includes categorising add ons by a traffic light system and pgt-a isn’t rated green.

At a talk by the leading embryology researcher here it was explained that the cells tested are placenta cells, and in many cases 1) contain multiple dna strains so it’s contentious how relevant the strain tested actually is 2) the inner cell mass that becomes a baby is completely separate so no guarantee the 2 correlate and 3) doing the treatment can technically only maintain or reduce your chance of success, not increase, as you are either maintaining or reducing the available embryos to transfer.

In all cases there’s genetic tests offered at 12 weeks anyway.

The hospitals here don’t offer pgt-a at all. The view is they cost 50% of running another full cycle, so to be worthwhile the increase in chance of success needs to be 50% of the increase in success from of the new cycle, and it’s not. It doesn’t increase success on the whole at all. It only increases the chance the first transfer succeeds. Private clinics universally do them and advocate for them but those who don’t stand to profit from it see it differently.

Wondering what the view is in other countries.

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u/allthatjoeydid — 4 days ago
▲ 1 r/IVF

For anyone going through ivf/freezing stims in your 40s how bad are the side effects?

Looking to know what to expect in terms of physical and hormonal impacts specifically in early 40s

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u/allthatjoeydid — 4 days ago
▲ 23 r/IVF+1 crossposts

Would a man ever want to raise his partners donor embryo?

I have an impossible situation. Just left a 10 year (abusive) relationship. I’m 41. we were trying to do ivf the last two years, thankfully it didn’t work. But I’ve always wanted a family.

Clinics are recommending freezing embryos using donor sperm if i want a shot at a child that’s genetically mine (which i do). But if feels like doing that is a commitment to going solo as I can’t imagine a partner wanting to have a family with me and my donor embryo. But it’s the best way to keep that dream alive, 35% chance of success per embryo, over 70% if you have 3.

Freezing eggs at this age is discouraged though if I insist I can do it. A high success rate clinic has a 15% success rate with eggs frozen at my age if you can get 10, 6% if less than 10. So it’s a moonshot but emotionally keeps the door open at having a child that’s both mine and a partner’s.

I’m not opposed to using donor eggs with a partner but wouldn’t do that alone. And I would feel the loss of that genetic connection. My family survived some crazy geopolitical conflicts and it kinda kills me to have it all end with me.

It feels like i have to decide my future while still in divorce proceedings ugh I hate this part of female biology

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u/allthatjoeydid — 7 days ago