u/babyjayco

Hello… I have a quick question about this medication. I had to get an angiogram that said I had 50% stenosis in my ostial LAD. Interventional Cardiologist wanted me on a statin. Tried that and failed miserably. He ended up running a genetic test and it showed that I cannot process any kind of statin.

Long story short, he prescribed Repatha and his personal opinion is that this medicine is the best available.

I’ve looked up this medication and searched a lot of posts, but I see it mainly being taken by people who just have high cholesterol and LDL. I’m looking for any accounts of people who have actually have documented coronary artery disease, taking this without a statin.

I know this will lower my LDL which is currently at 92 but will it also stabilize and help my plaque? My CAC score was zero but I had this 50% stenosis of noncalcified.

I hope he’s right because I can’t progress any further.

Side effects?

Thanks!

So I had to get an angiogram done a couple weeks back. It came back that I have 50% stenosis in my ostial LAD. They put me on Crestor and it was awful. My cardiologist ran some genetic testing and it turns out I am intolerant to all statins. Something about the way I processed and makes them build up in my system and causes terrible side effects.
He switched me to Repatha. I'm nervous about trying it. Unfortunately, I read too much on here about side effects and that has me anxious.
Most people I read with this medication are just trying to lower their cholesterol and I don't find a lot of accounts of people with actual LAD stenosis, and their stories with this medication. I know this medication is powerful. Will lower your LDL but will it still give me plaque stabilization if I'm not on any statin and just Repatha?
I guess I'm looking for some positive feedback on this medication in my current situation.
Thanks!

So I had to get an angiogram done a couple weeks back. It came back that I have 50% stenosis in my ostial LAD. They put me on Crestor and it was awful. My cardiologist ran some genetic testing and it turns out I am intolerant to all statins. Something about the way I processed and makes them build up in my system and causes terrible side effects.

He switched me to Repatha. I'm nervous about trying it. Unfortunately, I read too much on here about side effects and that has me anxious.
Most people I read with this medication are just trying to lower their cholesterol and I don't find a lot of accounts of people with actual LAD stenosis, and their stories with this medication.

I know this medication is powerful. Will lower your LDL but will it still give me plaque stabilization if I'm not on any statin and just Repatha?
I guess I'm looking for some positive feedback on this medication in my current situation.
Thanks!

So I had to get an angiogram done a couple weeks back. It came back that I have 50% stenosis in my ostial LAD. They put me on Crestor and it was awful. My cardiologist ran some genetic testing and it turns out I am intolerant to all statins. Something about the way I process them and makes them build up in my system and causes terrible side effects.

He switched me to Repatha. I’m nervous about trying it. Unfortunately, I read too much on here about side effects and that has me anxious.

Most people I read with this medication are just trying to lower their cholesterol and I don’t find a lot of accounts of people with actual LAD stenosis, and their stories with this medication. I know this medication is powerful. Will lower your LDL but will it still give me plaque stabilization if I’m not on any statin and just Repatha?

I guess I’m looking for some positive feedback on this medication in my current situation.

Thanks!

Hello,

I am a male 51 years old. I had to get a nuclear stress test done last year. That was completely normal. I also had a normal CCTA done three years ago. I have a history of NSVT and I’m on metoprolol roughly five or six years.

I was having some chest pain a couple months ago so I went over to the ER. They wanted to repeat the nuclear stress test. I did that and the imaging and perfusion was normal, but this time I had some EKG changes. I will post the results below. Given this, my doctor wants me to repeat a CCTA. I guess my question is could this be a false positive on the latest nuclear stress test, and all this is just a bunch of unnecessary testing since I had a CTA done three years ago that was normal and a nuclear stress test a year ago that was normal? I also had a normal echocardiogram. Additionally, I had a normal cardiac MRI a year ago. The cardiologist while I was in the hospital when I had this nuclear stress test was not concerned due to previous testing and then I visited my regular cardiologist last week and he said let’s just get another CTA done. I’m a bit concerned that I might have a blockage or some sort of microvascular issue. I will add that I went to the hospital around midnight and I did not sleep all night except for maybe a couple hours due to being loud and busy and I had to do the nuclear stress test at 9 AM so I was basically going on two hours to three hours sleep out of the last 36 so I’m wondering if that has something to do with the EKG changes. I brought that up to my cardiologist and he kind of shrugged that off.

Thanks for any input. I’m thinking and hoping that this was just a false positive.

Nuclear Stress Test Summary (03/23/2026)
Protocol: Bruce treadmill
Exercise duration: 5 minutes 57 seconds
Exercise capacity: 7.0 METs
Peak heart rate: 153 bpm (90% of age-predicted maximum)
Resting HR: 74 bpm
Blood pressure: 111/80 mmHg at rest → 154/96 mmHg at peak exercise
Reason test stopped: Maximal exertion
Chest pain during test: None
Exertional hypoxia: None
ECG Findings
Baseline ECG: Normal sinus rhythm
Peak exercise:
1.0 mm downsloping ST depression in the inferior leads (II, III, aVF)
0.5 mm horizontal ST depression in V4–V6
Nuclear Imaging Findings
Normal myocardial perfusion at rest and stress
Normal left ventricular size
Normal wall motion
Left ventricular ejection fraction (LVEF): 69%
No significant differences compared with prior SPECT study (10/30/2024)
Overall Impression
Abnormal stress ECG with 1 mm downsloping ST depressions concerning for ischemia.
Normal rest and exercise myocardial perfusion imaging.
Normal left ventricular systolic function (EF 69%).
Low-risk study.
Because the ECG and imaging results were discordant, clinical correlation was recommended.
Duke Treadmill Score: +1