r/repatha

I'm in my early 50s and had a heart attack about four years ago. I can't tolerate statins, so my cardiologist suggested Repatha. I was hesitant because I'm on Mounjaro, and injectables tend to give me flu-like symptoms.

The first injection wasn't too bad. The second one - oh my.

The next day I felt like I did after my heart surgery. My whole body felt incredibly heavy, I ached everywhere, and even moving around felt like a huge effort. My left side felt especially heavy, which really worried me. (I have an old neck injury that can flare up when I'm not feeling well, but this was much worse than usual.)

The biggest issue, though, has been the fatigue. I'm exhausted all the time. I'll sleep 9-10 hours, get up, shower, and then feel like I need to go back to bed. I have no energy to do anything, not even go for a walk. It's like a brutal jet lag - these waves of tiredness.
I've started B12 drops just to see if it helps.

I was ready to stop Repatha because I honestly didn't think it was worth it. But after reading so many experiences on this from you guys, I've decided to stick with it for another couple of months to see if my body adjusts.

My doctor says it's "rare" that this extreme fatigue happens, so I told him to check out this forum!

Those of you that had this - when did the fatigue subside? 2nd month maybe? (I'm trying to be hopeful here)

I got put on this medication just yesterday. I have a family history of genetically high cholesterol. My numbers are borderline high and rising. I'm just curious as to when you would start to see the effects of this medicine kick in?

I've been on repatha for two years. Every time I get my script re-fill I have to argue with the pharmacy about the price. $25. They tell me that my card has expired. I go home and call the repatha help line, wait, wait wait. They tell me that my card is NOT expired and to go back and have the pharmacist call them. This does not work well for a busy pharmacy. Anyone have any advise for purchasing that is easier? I have a Dr. Appt in two months and I will be switching to something else. Thanks for any advice!

Hi all. I’m a marathon runner, 49 male with 275 cholesterol thanks to a genetically high LPa. I’ve taken a break from serious training and have started Repatha to get this under control. My first dose was last Friday and I’ve noticed a big drop off in endurance. My first run after the dose was supposed to be an 8 mile easy run on Sunday. After two miles in I had to call my wife for the dreaded ‘pick-up.’ I will chronicle my progress here and hope this subsides or goes away completely. Run #2 was Tuesday (4 days after dose 1) and I got 4.2 in but was still incredibly drained. Anyone else a runner on Repatha? Have you had similar issues?

I know you’re supposed to refrigerate Repatha long-term, but I also heard that it’s OK if you let it be at room temperature for a while. I’m traveling and it was not refrigerated for about 12 hours. What do you think?