u/beavertail_blossom

Sharing a video on Mesotox (mesotherapy with diluted botulinum toxin) from Danesthetics Medical:

https://youtu.be/6LGXVBMHXws?si=dnf-BbrhL5-1eX2l

Have you tried mesotox or microneedling with diluted tox and is it a treatment you would do again? How long did the effects last for you? In this video he states the results can last 6 to 8 weeks---in my experience a mesotox, or a tox microneedling treatment does give a temporary glow, and it can be a nice treatment before an event, but the effects are pretty short lived.

Hi Everyone,

I wanted to share information from a recent clinical study where tranexamic acid is used to treat redness and broken capillaries (telangiectasias). As someone who deals with Type 1 rosacea this is something I’ve been trying myself in my treatment rotation for the last year or so and I hope this information may be helpful to others.

Tranexamic acid (TXA) is a synthetic analog of the amino acid lysine. It’s been used in medical settings since the 1970’s and more recently has been used as an effective treatment for melasma and hyperpigmentation. TXA’s applications for treating rosacea, particularly for reducing redness and improving the skin barrier, is a relatively more recent development over the last 10 years with topical and oral use as a medication as the most common modalities for treatment. Within the last few years, several researchers have now been looking at the effectiveness of TXA via microneedling and intradermal injections (mesotherapy) as a rosacea treatment.

Below I am linking a research article by Mohamed et al (2024). The researchers conducted a split-face study where 45 patients with erythematotelangiectatic rosacea (ETR) were treated for three sessions at two week intervals with microneedling at 0.5mm to 1.5mm depth combined with TXA on the right side of the face; and 10% TXA applied topically only on the left side.

Results: Erythema (redness) results showed statistically significant improvement on both sides of the face with either treatment modality; however, when both sides were compared, the side treated with microneedling and TXA had notably better outcomes than the side that was treated with TXA alone. Improvement of telangiectasia was also superior on the side of the face that was treated with microneedling and TXA (66.6% of patients achieved good to excellent results while the other side of the face treated with the topical application of TXA only had poor to no results). Evaluation of facial flushing also demonstrated significant improvement with microneedling and TXA when compared to TXA alone.

While limited, the data from this study is promising and demonstrates that TXA used with microneedling can be an effective and economical treatment for treating erythema (redness) and telangiectasia.

Anecdotally, I’ve been using sterile TXA with microneedling once every 4 to 6 weeks for about a year now and I’ve seen an approximately 25 to 30% reduction in the visibility of telangiectasia on my face and an even bigger improvement in redness reduction and relief from facial flushing, so I am a believer that this treatment can be effective for some people with consistent use. It’s not a miracle worker, and the results are not as immediate or pronounced as in-office treatments with a vascular laser, but it is an easy and inexpensive treatment that can be DIY’d with microneedling at home.

I would love to hear peoples thoughts and questions in the comments.

If you are wondering where you can find sterile tranexamic acid for use with microneedling, I’m providing some links to vendors with sterile injectable grade TXA  in the comments below.

PDF of study: https://pmc.ncbi.nlm.nih.gov/articles/PMC10911261/pdf/jcad_17_2_47.pdf

Citation: Mohamed RR, Mahmoud Mohamed LG, Mansour M, Rageh MA. Topical 10% Tranexamic Acid with and without Microneedling in the Treatment of Erythematotelangiectatic Rosacea: A Split-face Comparative Study. J Clin Aesthet Dermatol. 2024 Feb;17(2):47-51. PMID: 38444423; PMCID: PMC10911261.

The information in this post is not professional medical advice and is for educational purposes only.

I’ve tried out a few different PN products (Polynucleotides, aka “Salmon DNA” ). This year I want to try and start using more 2 and 2.5 percent PN which has solid data as a heavy hitter for collagen production and skin renewal. Today I’m going to complete my third session of Nucleofill Strong which is an Italian-made 2.5 percent PN with strong clinical data and CE certification.

This PN has a high viscosity and can be used with the 5-point BAP injection technique. I’m following the manufacturer’s clinical protocol, which is 2 to 4 consecutive treatments, with each treatment spaced every 2 to 4 weeks.

It’s been a few weeks since my second treatment and so far, this is one of the few products I feel like I’ve gotten notable results with this quickly. I’ve been looking forward to round three and I’m definitely keeping strong PN in my rotation after I finish this series.

I’d like to hear other people’s experiences with PN and which PN’s have been your favorite so far!