u/DIY4thePeople

I'm sharing some product information slides form the manufacturer (Mastelli) brochure for the Plinest line. Plinest is one of the most reputable, well-researched, and evidence-based brands of polynucleotide (PN) products. Mastelli is an Italian based pharmaceutical company whose founder began researching regenerative medicine in the early 1950s. The company has been researching and developing PN/PDRN since the 1980's. The Plinest line was released more than 20 years ago, and Mastelli is considered to be a worldwide leader and an originator/pioneer of the use of polynucleotides for aesthetic and regenertive medicine. As of 2025, Plinest is the most researched brand of polynucleotide products, with data available from more than 100 scientific publications.

A few things to note (info from Mastelli)--

Mastelli has an exclusive high purification technology to produce their PN. Mastelli Plinest PN is produced in-house on their own European based trout farms that undergo rigorous quality control. Plinest was the 1st CE marked polynucleotide-based medical device registered in 2005 for intradermal injection and is the first and only polynucleotides sourced from EU fish farms.

There are multiple different products in the Plinest line, formulated for different uses and different areas of the body/face, including several new recently released products:

Plinest:

• Formulated for the face
• Contains 40mg PN/2ml
• One 2ml syringe

Plinest Eye:

• Formulated for the eye area
• Contains 15mg PN/2ml
• One 2ml syringe

Plinest Fast:

• Formulated for sensitive areas
• Contains 15mg PN/2ml
• One 2ml syringe

Plinest Hair:

• Formulated for hair and eyebrows
• Contains 15mg PN/2ml
• One 2ml syringe

Plinest Newest:

• Formulated for the face, neck, and decollete
• Contains 20mg PN/2ml
• Linear HA 20mg/2ml, and Mannitol
• One 2ml syringe

Plinest One:

• Formulated for "extendended areas"/body
• Contains 8mg PN/4ml
• Five 4ml vials

Plinest Newest One:

• Formulated for "extended areas"/body
• Contains 4mg PN/4ml
• Linear HA 4mg/ml, and Mannitol
• Five 4ml vials

Plinest NewGyn:

• Formulated for the genital areas
• Contains 20mg/2ml
• Linear HA 20mg/2ml, and Mannitol
• One 2ml syringe

Plinest products are available for a competitive price at Wimpole Fillers. Note if you choose to purchase from Wimpole we have a 5% discount with code DIYSCIENCE.

I have some Plinest, Nucleofill, and other European goodies arriving tomorrow!!! 😄 ❤️ 🔥

Meamo is offering 30% off (15% off, plus an extra 15% off with code DIYSCIENCE) all products in their "newly curated" category: https://meamoshop.com/newly-curated/

If you need to restock on toxin, this is a great opportunity to get Neurovie, Nabota, or a few other new Korean toxins at 30% off.

There are some other interesting products and goodies in the 30% off sale category including:

• Jeunetique NAD+ (NAD+, NMN, plant-derived exosomes, PDRN, HA, collagen, and peptides)
• Soonsu Ultra Reju  (1% PN, 1% PDRN, hyrdrolized collagen, niacinamide and peptides)
• Soonsu Ultra White (tranexamoyl dipeptide-23, glutathione, vitamin C, arbutin, and peptides)
• Rejuvenex cream (pharmaceutical-grade skin recovery cream formulated with PDRN)
• Melsmon (premium Japanese-manufactured pharmaceutical grade placenta extract)

Note products not in the newly curated category are still also 15% off with code.

Sale runs from July 4th through 14th (Korean time)

You must be logged in and pay with Wise or bank transfer if you would like to purchase toxin.

I’ve been looking into Juvelook a bit lately and I'm sharing the article "skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study" (Seo et al. 2023, originally published in the Journal of Cosmetic Dermatology)

Poly D, L-lactic acid (PDLLA) is a biodegradable collagen stimulator that has become a more popular treatment in recent years. This study assessed the efficacy and safety of injectable PDLLA in participants with skin aging changes. The study evaluated how injectable treatment using PDLLA combined with non-cross-linked hyaluronic acid affected specific signs of skin aging including wrinkles, rough skin texture, pigmentation, facial erythema (redness), and telangiectasia. Sixteen participants were included in the study and patients were evaluated after two to three treatments.

PDLLA Preparation and Protocol Used:

• PDLLA/HA: PDLLA 42.5 mg + HA 7.5 mg (product used was Juvelook) was dissolved in 10 mL mixture of HA, 1% lidocaine (2.5 mL), and normal saline (5 mL) mixture at a 1:1:2 ratio.
• Treatments were performed two to three times at four-week intervals.
• 4 mL of the diluted PDLLA mixture was injected into the upper dermis  across the face (forehead, temple, cheek, chin, nose, and posterior auricular area) via mesotherapy through 32 gauge needles (in this case they used an automated mesotherapy injector device)

Assessment and Results:

Patients were evaluated at baseline, and follow up visits at 16 weeks or 12 weeks after the final treatment. The results were interesting. Overall, statistical significance was shown in all evaluated categories of aging (fine wrinkles, skin texture, irregular pigmentation, telangiectasia, and facial erythema).

• Fine wrinkle score decreased from 6.25 before treatment to 3.88.
• Skin texture decreased from 6.75 to 4.00.
• Irregular pigmentation decreased from 7.38 to 4.38.
• Telangiectasia decreased from 6.88 to 4.75.
• Facial erythema decreased from 6.75 to 5.0.

In summary skin aging signs improved in the above mentioned categories. PDLLA injection also showed a facial contouring effect. No serious adverse events were identified except temporary procedural pain and temporary facial erythema.

Another interesting part of the study were the results from a histologic evaluation. Biopsy samples were taken from some participants and the histopathological findings demonstrated an increase in collagen fibers and an increase and thickening of elastic fibers within the dermis. In other words, the study did not simply show that the skin looked better in photos, it also confirmed structural changes within the skin, which makes these findings more interesting.

Discussion and Conclusions:

The authors of the study conclude the paper with an interesting discussion on the benefits of “hydrolifting” for skin rejuvenation vs the use of conventional HA fillers. Aging skin generally shows wrinkles and decreased elasticity. These changes in the skin are due to the reduction of collagen, elastic fibers, and other proteins in the dermis--depletion of hyaluronic acid can explain these aging mechanisms. Because HA can attract water hundreds of times its molecular weight, supplementing HA in the dermis has skin rejuvenating effects. With conventional HA filler, relatively large amounts of HA are injected directly into areas can have some adverse events including vascular complicaions, and in some cases allergic reactions. “Hydrolifiting” involves injecting a small amount of a skin booster over several sessions into a large area, such as the whole face. Through this method, there is a minor volumizing effect compared to HA filler but a more profound impact on skin rejuvenation.

PLLA is a biocompatible and biodegradable polymer that breaks down into lactic acid to stimulate collagen synthesis (PLLA injection was originally approved to treat HIV-associated facial lipoatrophy more than 20 years ago). PLLA has a longer lasting effect than HA and thus requires fewer procedures to maintain results. However, the downside of injectable PLLA is it is known to induce a local skin reaction and stimulated a foreign body reaction. Because of the mechanisms behind these reactions, skin thickening can occur with PLLA use and there are some reports of late-onset granuloma formation after PLLA injections.

PDLLA is related to PLLA as a molecule. PDLLA and PLLA have different microsphere shapes even though they share the same chemical forms. PDLLA particles in Juvelook are spherically shaped and are empty inside because of their “foamy feature”. PDLLA has a significant volume restoring effect because it occupies a larger volume than PLLA for the same weight. The authors of the study explain PDLLA would have a lower likelihood of forming granuloma compared to other PLA-type particles. Studies have also shown that PDLLA can increase the extracellular matrix by modulating macrophages and increasing adipose-derived stem cell proliferation.

Overall, I thought this study was interesting because it demonstrated PDLLA can improve not only the appearance of wrinkles and increase collagen, but also improve skin texture, and reduce pigmentation, redness, and telangiectasia. I also appreciated the explanation of how PDLLA may have less risk of granuloma formation than PLLA. Limitations of the study are the relatively small study group size, and the short follow up period. I’d like to see more studies that look at the long term results of PDLLA.

Citation and link to study:

Seo SB, Park H, Jo JY, Ryu HJ. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study. J Cosmet Dermatol. 2024 Mar;23(3):794-802. doi: 10.1111/jocd.16085. Epub 2023 Nov 15. PMID: 37969055.

https://pubmed.ncbi.nlm.nih.gov/37969055/

Full text pdf download: https://doi.org/10.1111/jocd.16085

I bought bought these inexpensive tranexamic acid and niacinamide sheet masks a couple of weeks ago and wanted to share. I ordered them from iHerb (I'm not affiliated with this product or with iHerb but I thought this was a good find for anyone with rosacea or melasma who might be interested)

Product info:

"Powered by 17.2% Tranex Niac Cen™ (containing tranexamic acid, niacinamide and centella asiatica leaf water)"

Full list of Ingredients:

Aqua (water), centella asiatica leaf water, butylene glycol, dipropylene glycol, 1,2-hexanediol, hydroxyethyl urea, propanediol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, hydroxyacetophenone, carbomer, arginine, glycerin, tranexamic acid, niacinamide, disodium edta, cellulose gum, dipotassium glycyrrhizate, glyceryl acrylate/acrylic acid copolymer, xanthan gum, inulin, cellulose, fructose, glucose, polyglucuronic acid, squalane, asiaticoside, madecassic acid, asiatic acid, sodium hyaluronate, melaleuca alternifolia (tea tree) leaf extract, hippophae rhamnoides fruit extract, hydrolyzed collagen, beta-glucan, caprylyl glycol, nelumbium speciosum flower extract, artemisia annua extract, oryza sativa (rice) extract, saccharomyces ferment, solanum melongena (eggplant) fruit extract.

I liked the ingredients stack in this product and I like that there's no added fragrance. I was especially interested in the high concentration of tranexamic acid after reading a couple of studies on the effectiveness of topical use of tranexamic acid (TXA) or TXA "soaking" with a wet dressing either alone or in combination with microneedling with TXA. I have been experimenting with microneedling with TXA as a treatment for my rosacea for a while and I have also been using topical TXA. I think these sheet masks would be a more convienent and inexpensive option than basically soaking wet gauze in TXA as was done in this study:

"The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea" (Bageorgou et al. 2018) compared the effects of 10% TA solution alone with those of a combination of 10% TA solution and microneedling to treat rosacea. In their study, 10 patients were treated for erythematotelangiectatic rosacea (ETR) with a wet dressing infused with 10% TA solution for 20 min every 15 days for four sessions; an additional ten patients were treated with a combination of microneedling and wet dressing therapy. The results showed significant improvements in the clinical severity and quality of life in both groups. The results of the combination therapy group were slightly better than those of the TA-only group.

https://pubmed.ncbi.nlm.nih.gov/30099833/

Other similar articles:

Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study.

Xu Y, Ma R, Juliandri J, Wang X, Xu B, Wang D, Lu Y, Zhou B, Luo D.Medicine (Baltimore). 2017 May;96(19):e6897. doi: 10.1097/MD.0000000000006897. PMID: 28489798

Tranexamic Acid for the Treatment of Hyperpigmentation and Telangiectatic Disorders Other Than Melasma: An Update.

Chen T, Xue J, Wang Q. Clin Cosmet Investig Dermatol. 2024 Sep 25;17:2151-2163. doi: 10.2147/CCID.S479411. eCollection 2024. PMID: 39350932

Tranexamic acid solution soaking is an excellent approach for rosacea patients: a preliminary observation in six patients. (no abstract available)

Kim MS, Chang SE, Haw S, Bak H, Kim YJ, Lee MW.J Dermatol. 2013 Jan;40(1):70-1. doi: 10.1111/j.1346-8138.2012.01515.x. Epub 2012 Nov 1.PMID: 23116067

(There are quite a few other studies on microneedling with TXA or the use of topical TXA to treat melasma and rosacea).

Get Glowing is having a sale for the July 4th holiday that is happening now. They are a US based company with wonderful customer service and a great selection of skin boosters, korean skincare, threads, microneedling supplies, and more! If you are in the U.S. they offer free fast shipping with no tariffs which is a huge plus.

The current sale is 21% off with code DIYSCIENCE

I'm sharing some information on Aestacell Bella B Skin Booster. I came across this product when I was researching skin boosters that contain tranexamic acid as an ingredient (great for roasacea and pigmentation) and I hadn't heard of this booster before. This product is available at Get Glowing and I'm planning to order it during their current sale to try it out with microneedling and mesotherapy.

It contains a good combo of brightening ingredients (glutathione, niacinamide, asorbic acid/vitamin C, arbutin, and tranexamic acid), hyaluronic acid, atelocollagen, PDRN, and peptide growth factors.

Bella B was launched in 2025 and is manufactured in South Korea by USKIN. The manufacturer's website is here: https://uskinlab.com/

It's available here at Get Glowing (currently 21% off with promo code DIYSCIENCE. Get Glowing offers free U.S. shipping--and no tariff charges for those of us in the U.S.)

Has anyone tried this booster? They also have a NMN/NAD⁺ focused booster (Bella A).

Glamcosm is having a SUMMER GLOW SALE!

They have wonderful catalog of products and are offering a 30% discount with promo code DIYSCIENCE 

Promo code is applied to All products including - Already discounted products

Date:  JUNE 23- JULY 3

Payments accepted: CC, Sezzle, Wise, and Remitly

Please note you must be a Member to see all categories--email  info@glamcosm.com with code DIYSCIENCE and they will upgrade your membership (membership is free).

USA time:

PDT: 8 am ( June 23 ) - 8 pm ( July 3 )

MPT: 9 am ( June 23 ) - 9 pm ( July 3 )

CPT: 10 am ( June 23 ) - 10 pm ( July 3 )

EST: 11 am ( June 23 ) - 11 pm ( July 3 )

For anyone interested in techniques for the use of toxin on the neck, I'm sharing some images and text from the open source article "Extra facial esthetic indications of botulinum toxin: A review" (Arora et al. 2024).

Botulinum toxin has been used for numerous off-label aesthetic indications, the majority being facial indications. In this review article, the authors discuss several extra off-label aesthetic uses of toxin including neck rejuvenation. Toxin can be used as a quick and economical alternative to more invasive procedures for indications of neck aging including horizontal neck wrinkles, crepey skin, sagging of skin with hanging folds, excessive adipose tissue causing double chins and/or poorly defined jawlines, and platysmal bands.

The article discusses injection techniques for 1) vertical bands, 2) horizontal neck lines, and 3) microbotox (superficial intradermal inections using diluted toxin to treat mild neck laxity and jowling, crepey neck, horizontal neck lines, and vertical banding).

The full pdf of the article can be downloaded here: https://cosmoderma.org/extra-facial-esthetic-indications-of-botulinum-toxin-a-review/#tab_default_03

Citation:

Arora G, Singh N, Arora S. Extra facial esthetic indications of botulinum toxin: A review. CosmoDerma. 2024;4:32. doi: 10.25259/CSDM_259_2023

Two of the most popular skin boosters from Meamo right now are Jeunetique Exo and Jeunetique NAD+. Both of these products offer a great stack of ingredients to be used with microneedling or mesotherapy. I wanted to share some slides with information from Meamo to help explain the ingredients and function of each of these products, as there are some similarities but also a few key differences.

Jeuntique Exo

Active Ingredients:

• Exosomal Vesicles (at least 1.3 billion highly purified exosomes per mL)
• Lactobacilli
• Totipotent Callus Cells from ginseng (Panax ginseng)
• Totipotent Callus Cells from Centella Asiatica
• PDRN (Polydeoxyribonucleotide)
• Atelocollagen
• Hydrolyzed Collagen
• Ultrashort Peptides (Galloyl Pentapeptide, Nicotinoyl Tripeptide-1, Nonapeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Biotinoyl Tripeptide-1)
• Growth Factors

Method of Action and Benefits:

Jeunetique Exo introduces active signaling molecules into the dermis using exosomes. The product contains nano-sized (30-100 nm), highly purified plant exosomes in an amount of at least 1.3 billion/mL. The product contains other synergystic antiaging ingredients including PDRN, atelocollagen, cellular growth factors and ultra-short peptides. The relatively high concentration of PDRN (3%) stimulates cellular renewal, boosts collagen production, and accelerates tissue repair. PDRN can also reduce fine lines and soothe inflammation.

Jeunetique NAD⁺

Active Ingredients:

• Nicotinamide adenine dinucleotide (NAD+)
• Nicotinamide mononucleotide (NMN)
• Exosomal vesicles (isolated from callus cells, the plant equivalent of stem cells, obtained from Panax ginseng, Centella asiatica, and Camellia japonica)
• PDRN (polydeoxyribonucleotide)
• Atelocollagen
• Hyaluronic acid
• Growth factors
• Ultra-short peptides

Method of Action and Benefits:

Jeunetique NAD⁺ is designed for mature (age 40+) skin, or post-procedure and damaged skin. The dual NAD⁺ and NMN formula directly addresses one of the main drivers of skin aging: age-related NAD⁺ depletion. As we age, cellular energy drops, fibroblasts slow down, collagen production declines, and skin loses firmness. Jeunetique NAD⁺ is formulated to restore metabolic activity inside skin cells. It also contains many beneficial ingredients found in other skin boosters including plant derived exosomes for cellular signaling; PDRN for tissue repair; atelocollagen and hyaluronic acid for improving structure and hydration; and growth factors and peptides for collagen stimulation and wrinkle reduction.

Both products are available as either as single set (two vials--one liquid vial and one freeze-dried vial) or a full box of 5 sets (10 vials--five liquid vials and five freeze dried vials). For both products, each set contains 6mL plus 100mg of product.

The full product brochure for Jeunetique Nad⁺ is here, and Jeunetique Exo is here.

(Both products are part of the current buy two get one free Meamo Labs sale, with an extra 15% off with code DIYSCIENCE.)

Hi Everyone,

I've had great results after completing a series of sessions with Nucleofill Strong (2.5% polynucleotides) and I've been interested in researching the benefits of combining polynucleotides with other treatments.

I just rewatched a Nucleofill webinar that outlines several standard protocols using Nucleofill Medium (2% PN) and Nucleofill Strong (2.5%). The webinar also discusses some options for advanced protocols for more intensive regenerative effects as well as some combined protocols that I found particularly intriguing. I'm sharing those protocols below for anyone interested.

Standard Protocol (for dehydrated skin, skin with mild laxity)

Four sessions spaced approximately two weeks apart

• First Session (Day 0): Nucleofill Medium (2% PN)
• Second Session (Day 15):Nucleofill Medium (2% PN)
• Third Session (Day 30): Nucleofill Medium (2% PN)
• Fourth Session (Day 45):Nucleofill Medium (2% PN)

or

• First Session (Day 0): Nucleofill Strong (2.5% PN)
• Second Session (Day 15): Nucleofill Strong (2.5% PN)
• Third Session (Day 30): Nucleofill Strong (2.5% PN)
• Fourth Session (Day 45):Nucleofill Strong (2.5% PN)

(And one maintenance session every two months.)

5-Point BAP Protocol (injecting into subcutaneous layer with Nucleofill Strong will give a lifting effect).

• First Session (Day 0): Nucleofill Strong (2.5% PN)
• Second Session (Day 15):Nucleofill Strong (2.5% PN)
• Third Session (Day 45): Nucleofill Strong (2.5% PN)
• Fourth Session (Day 60):Nucleofill Strong (2.5% PN)

(And one maintenance session every two months.)

Protocol for Severely Damaged Skin

This protocol alternates between different concentrations of PN. The idea is to maximize the cells response to PN by switching things up (they argue that by using a strong PN product over and over consecutatively the cell receptors will absorb the product less and less and it may become less effective).

Five sessions spaced approximately two weeks apart.

• First Session (Day 0): Nucleofill Medium (2% PN)
• Second Session (Day 15): Nucleofill Strong (2.5% PN)
• Third Session (Day 30): Nucleofill Strong (2.5% PN)
• Fourth Session (Day 45): Nucleofill Medium (2% PN)
• Fifth Session (Day 60): Nucleofill Strong (2.5% PN)

Combined Protocol with Non-Cross Linked Hyaluronic Acid (HA) This protocol alternates between HA and different strenghts of PN---for very dehydrated skin, aged skin, thinning skin, and loss of elasticity--for lifting and hydration.

• First Session (Day 0): HA (non-cross linked)
• Second Session (Day 7): Nucleofill Medium (2% PN)
• Third Session (Day 21): Nucleofill Strong (2.5% PN)
• Fourth Session (Day 36): Nucleofill Medium (2% PN)
• Fifth Session (Day 43): HA (non-cross linked)
• Sixth Session (Day 50): HA (non-cross linked)

Intensive Combined Protocol This protocol is for people with very damaged or mature skin (age 55 and up with skin laxity, oxidative stress, or uneven skin texture).

• Step 1 (Day 0): Nucleofill Medium (2% PN)
• Step 2 (Day 7): Nucleofill Strong (2% PN)
• Step 3 (Day 14): HA (non-cross linked)
• Step 4 (Day 21): HA (non-cross linked)
• Step 6 (Day 28): Nucleofill Strong (2% PN)
• Step 7 (Day 35): Chemical Peel

(Repeat once a year.)

I find the last three protocols particularly interesting. The concept of switching between different strengths of PN to maximize cellular response is something to consider. And I really like the idea of combining or alternating PN with HA treatments to maximize hydration, elasticity, and potentially other synergistic benefits. Some products I can think of that may pair well for this include Profhilo, Revs Pro 32, Jalupro Super Hydro, or recombinant human collagen (RHC) products with HA. I've also heard clinic practitioners discuss the benefits of combining PN injections with peels, microneedling, or laser treatments to accelearate cell turnover, increase collagen generation, and improve healing time, so it is exciting to see that Promoitalia has already recognized the potential of combined or combination treatment methods as a protocol.

If you haven't yet watched it, there is a Nucleofill webinar here which discusses the product research data and describes these protocols: https://www.youtube.com/watch?v=2YaQ7_jrBGc

If you are looking for Nucleofill or other high quality European polynucleotide products such as Plinest, PolyPhil/Croma PhilArt, or Plenhyage, you can find them at Wimpole: https://wimpolefillers.co.uk/?ref=DIYSCIENCE . We have a 5% discount with code DIYSCIENCE.

Sharing a recent video from Elanora Androva, a UK-based aesthetics educator (Dermacure). I've shared a few of her videos before because she is one of my favorite professionals to watch for treatment demos. In this video she discusses how filler has dominated the aesthetics industry for a long time, but medical aesthetics is now shifting to a focus on other treatments. She discusses her approach of using biostimulators, polynucletides, mesotherapy, microneedling, and chemical peels and her emphasis on improving skin quality while more holistically addressing the signs of aging rather than relying solely on filler as a quick fix to mask problems.

This is a really great discussion and I think she does a good job of explaning the current direction of medical aesthetics. To be clear, she's not advocating that everyone should go out and disolve all their filler, but emphasizes that it has been over used as a trend in the aesthetics industry for a long time. Filler is still a valuable tool in moderation but it should not be relied upon as the only tool in a toolkit. She also cautions that overuse of filler can not only lead to "filler blindness" but can affect lymphatic drainage an in some cases contribute to poor skin quality.

Today we have access to many amazing treatments and bioregenative substances that don't add dramatic volume or alter our facial features, but actually improve the skin and underlying cellular matrix so that we can still look like ourselves, but healthier. I thought this was a great discussion, and I think she is one of the few aesthetics educators and professional injectors who offer a very balanced perspective and is up to date with current advancements in aesthetic medicine.

If anyone else gives this video a watch, I'd love to hear your thoughts.

Watch on YouTube here: https://www.youtube.com/watch?v=ZkRrJ-mBFng

Her Instagram:   / dermacure.laser.clinic  
Her Website: https://dermacureclinic.co.uk

Sharing a few images of a Profhilo product brochure depicting "Neck Bioremodeling & BAP Technique". I know alot of us like to adopt this technique for not just Profhilo but other products including polynucleotides and I think it can be helpful to have a few quick reference images on hand.

Please note these are the manufacturer's product images and are not my images and I am not giving professional medical advice.

Father’s Day Sale (June 16–19, Korean Standard Time) https://meamoshop.com/

✅ 25% OFF Sitewide

✅ Additional discount applies with code DIYSCIENCE

🎁 FREE RONAS Waterfull Green Sun Cream for first-time customers (limited stock available).

For anyone looking to stock up on skinboosters, threads, toxin, or other products, the current promotion offers a great value (note, you must be logged in and must pay with Wise or bank transfer if you wish to purchase tox).

Someone turned me on to the Inside Aesthetics podcast a little while ago and if you haven’t checked it out yet, I encourage you to take a look at their library of episodes. It’s a podcast made for professional injectors and they have over 350 episodes! If there is a topic in skincare or aesthetics treatments you are particularly interested in at the moment, they probably have an episode on it.

The “Masterclass Series” of episodes is especially worth a listen, it features global experts in medical aesthetics with discussions focused on fillers, bio-stimulators, polynucleotides, exosomes and other products. They also have a toxin series.

On my drive this morning I listened to Episode 329 which features Dr. Ferial Fanian and mostly focuses on biostimulators. Dr. Fanian is a dermatologist who has researched aesthetic dermatology for over 20 years, has coauthored dermatology textbooks, and is currently Chief Scientific Director of FILLMED Laboratories (producers of NCTF 135).

You can find the episode here: https://community.insideaesthetics.com/c/episode-library/ep-329-masterclass-series-chapter-11-what-biostimulation-actually-is-how-to-classify-biostimulators-dr-ferial-fanian

And can access the podcast library here: https://community.insideaesthetics.com/c/episode-library/

Is anyone else listening to this podcast and do you have any episodes you found especially interesting? Does anyone know of any similar podcasts?

I’m sharing a 2026 presentation from Dr. Tingsong Lim, Principal Investigator and “Key Opinion Leader” for Masteli, Exocobio, HTL, and other leading medical aesthetics and biotechnology companies, and President of the Malaysian Society of Aesthetic Medicine. If you are interested in regenerative medical aesthetics, I really recommend watching this video, it’s a super interesting presentation (link to video below).

In this presentation he discusses bioregenerative substances in aesthetic medicine, including polynucleotides, and how those substances interact with cells and the ECM (extracellular matrix) to improve tissue quality, leading to long-term regenerative outcomes.

Key points from the presentation:

He talks about how we are in the “era of regenerative aesthetics” (yeah!!), and we should be moving away from focusing only on filler to give volume. Medical aesthetics is shifting to a focus on how to make tissues and the microenvironment of the skin healthy again as we age.

He discusses the extracellular matrix and the “four pillars of skin quality”: 1) skin tone evenness, 2) skin surface evenness, 3) skin firmness, and 4) skin glow

He talks about how skin is the upper surface of a complex ecosystem—skin quality depends not only on the dermis but everything beneath it and how those systems interact. The appearance of the skin surface reflects how healthy underlying systems are.

Old view: skin consists of static layers vs. new view: skin, fascia, and the cellular network is a complex and dynamic ecosystem. It’s now known that skin health is not as simple as previously understood--- you cannot draw a simple line between skin, fat, and muscles. Connective tissues, blood vessels, nerves, are all part of the extracellular matrix which is a complex living ecosystem and a dynamic continuum.

Researchers are now focusing on how to make the ECM healthier rather than overstimulating it. The trend in medical aesthetics is moving away from trying to use energy-based devices and a lot of injectables---just stimulating collagen is not going to make it healthier. Overstimulation won’t make a healthier ECM; overstimulation can also create fibrosis and expedite cell aging. He concludes by saying we should focus on improving the ECM with substances that contain nutrients, polynucleotides, and collagen for long term regeneration.

Link to video of presentation on YouTube

Glamderma is having SAME GLAM. NEW ADDRESS. SALE - on their new www.glamderma.co website.

They are offering a 40% discount with promo code DIYSCIENCE.

Promo code is applied to all products including already discounted products.

Date: JUNE 11 - JUNE 18

Payments accepted - Remitly & Wise

USA time:
PDT: 8 am ( June 11 ) - 8 pm ( June 18 )
MPT: 9 am ( June 11 ) - 9 pm ( June 18 )
CPT: 10 am ( June 11 ) - 10 pm ( June 18 )
EST: 11 am ( June 11 ) - 11 pm ( June 18 )