u/blueespadrille

Hello, I was recently accepted into a clinical trial for psilocybin/rTMS for treatment resistant depression (TRD).
And well, I’m nervous. I went through two screenings— one where they screened for TRD and another for general health. I passed both and now I have scheduled my two week period where I’ll actually *do* the study.

The premise is this: There’s two days of therapy/prep, then I get either 1mg lab-synthesized psilocybin or 25mg lab-synthesized psilocybin, followed by two more days of therapy or “integration”.

The following week, I’m there for 10 hours a day for 5 days where they give me either real or sham rTMS. They’re trying to see if the combination of those two treatments makes for a more durable long term treatment of TRD.

The study info, if anyone is interested: https://clinicaltrials.gov/study/NCT06132178#study-plan

Here’s what I am wondering— what the hell is 25mg of pure, lab synthesized psilocybin going to be like? What would be the comparable equivalent in grams of shrooms?? I have done shrooms before (3g penis envy each time) but i know this will be a crazy dose in comparison.

I know I will get to talk to my team when the study begins, and I could reach out to them, but I’m wondering what experiences people might have out there, in a more informal way. I have only been able to find two records of ppl talking abt their experiences on 25mg pure psilocybin and they both sounded pretty scary and negative and maybe I want to hear some more positive experiences? I feel pretty desperate for relief, but scared this might make things worse somehow.

Hello, I was recently accepted into a clinical trial for psilocybin/rTMS for treatment resistant depression (TRD).
And well, I’m nervous. I went through two screenings— one where they screened for TRD and another for general health. I passed both and now I have scheduled my two week period where I’ll actually *do* the study.

The premise is this: There’s two days of therapy/prep, then I get either 1mg Comp360 psilocybin or 25mg Comp360 psilocybin, followed by two more days of therapy or “integration”.

The following week, I’m there for 10 hours a day for 5 days where they give me either real or sham rTMS. They’re trying to see if the combination of those two treatments makes for a more durable long term treatment of TRD.

Here’s the study info for those interested

Here’s what I am wondering— what the hell is 25mg of pure, lab synthesized psilocybin going to be like? What would be the comparable equivalent in grams of shrooms??

I know I will get to talk to my team when the study begins, and I could reach out to them, but I’m wondering what experiences people might have out there, in a more informal way. I have only been able to find two records of ppl talking abt their experiences on 25mg comp360 and they both sounded pretty scary and negative and maybe I want to hear some more positive experiences? I feel pretty desperate for relief, but scared this might make things worse somehow.