Medicare covers GLP-1s for weight loss starting today -- info on prior auth and eligibility

Medicare just started covering GLP-1s for $50/month through a new program called Bridge. It goes from today (July 1) to the end of 2027 (another GLP-1 program, BALANCE, is anticipated to start after that). Here's some info about which patients are eligible, and what needs to happen to actually get GLP-1s covered for your patients.

All patients with BMIs of 35, and some patients with BMIs 27-35, have coverage, so long as their Medicare Part D plan wouldn't normally cover a GLP-1 (more on that in a sec). Patients with a BMI of 27-35 are eligible if they have other chronic conditions or medical history in this table:

Patient BMI What else they need
35 or higher Nothing else required
30 or higher Heart failure with preserved ejection fraction, uncontrolled high blood pressure, or chronic kidney disease (stage 3a or higher)
27 or higher Pre-diabetes, a prior heart attack, a prior stroke, or symptomatic peripheral artery disease

Medicare Bridge covers Foundayo tablets, Wegovy as an injection OR tablets, and Zepbound.

  • Single-dose Zepbound pens and vials are NOT covered.

To get coverage, the patient's physician needs to submit a prior authorization form. You can download the PDF directly from Medicare here or use this Medicare GLP1 prior auth PDF form filler to generate a PDF ready for signing. The form itself has various questions about the patient that correspond to the eligibility criteria above. Note that before submitting this form, the pharmacy should submit a claim which is denied.

A few more notes on eligibility, edge cases, operations, etc:

  • You don't actually have to be enrolled in Medicare to prescribe your Medicare patients GLP-1s, but you can't be on the Preclusion List.
  • Medicare Part D coverage. Some patients were already eligible for GLP-1 coverage through Medicare Part D. If that's the case, they're not eligible for Bridge. However, there is a new cost cap of $2,100 per year for Medicare Part D, so your patients in this category do have cheaper access to GLP-1s than before (even if the out of pocket cost is higher than most of us would like). Medicare Part D covers GLP-1s for T2D, moderate-to-severe sleep apnea, or MASH; for those patients, the pharmacy submits claims directly to the Part D plan as usual and nothing changes.
  • Prior auth claims can be submitted starting today, July 1. Medicare says you'll hear back within 72 hours.
  • After the prior auth is is approved, subsequent fills don’t require a new prior auth (unless you change the patient to a different medication). Only 28-day or 30-day fills are covered under Medicare GLP-1 Bridge for now.

Medicare has more official documentation here, but the above covers the basics and I hope it's helpful!

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u/brandonballinger — 4 days ago

New generations are aging faster biologically, raising cancer risk

Early-onset cancer rates have increased 24% in the last 30 years. A new study in Nature Medicine explored an interesting hypothesis: that the increase is driven by faster biological aging.

The researchers used PhenoAge and other formulas to calculate biological age for 154,169 participants form UK Biobank participants and 10,262 from All of Us. Then they calculated an age gap (biological age - chronological age), and plotting it out by generation. Younger generations have a faster rate of biological aging (the effect is stronger in men than women):

https://preview.redd.it/gih8ymgztw8h1.png?width=495&format=png&auto=webp&s=0253281805b62eecfcc603001f780b7aad16d064

Does this age gap correlate with early onset cancer? Yes -- in the study, each standard-deviation increase in PhenoAge gap was associated with 8% higher risk of cancer overall.

They also used proteomics to calculate per-organ aging, and correlated it with various cancer sites. They found immune aging was highly correlated with lung cancer, for instance.

https://preview.redd.it/udhh4nj0uw8h1.png?width=1076&format=png&auto=webp&s=51dcff6d4302502da0df8aa15b1fb28801e4c291

Overall a cool study, and worth a read. I also summarized the main results here.

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u/brandonballinger — 13 days ago

Interviewing a cardiology professor about Lp(a) - questions you'd like answered?

I'm interviewing a cardiology professor at UC San Diego who's recently authored a bunch of studies on Lp(a), including prevalence in testing trends, using CAC scoring in people with Lp(a), digital biomarkers, impact of PCSK9 Inhibitors on Lipoprotein(a), and so on. He's also done machine learning as applied to cardiology, so you can ask about that.

I have a bunch of my own questions, but I thought people here may have questions they want answered. I'm always surprised about the depth of expertise I see in the answers here. Anything you'd like me to ask and include in the interview?

I'll post the transcript of the interview once we complete it.

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u/brandonballinger — 25 days ago
▲ 3 r/PeterAttia+1 crossposts

Biomarkers that that change the most as we age

This chart shows the 5 biomarker each that rise or fall most strongly with age. Some interesting things I noticed:

  • Kidney function (eGFR) declines more strongly with age than any other biomarker discussed. Some older adults maintain youthful kidney performance through healthy blood pressure, glucose control, and avoiding chronic NSAID use.
  • Immune aging is reflected in declining lymphocyte counts.
  • Two of the top five risers, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), are about the size of red blood cells. Common reasons MCV goes up are low B12 or folate.
  • Hemoglobin A1c rises gradually: a 25-year-old with an A1c of 5.0 will, on average, sit closer to 5.5 by 70 even if they never develop diabetes.

I wrote a more detailed writeup here, but thought this community would enjoy the analysis and some of the more interesting insights.

u/brandonballinger — 1 month ago

Most people here probably know that Lipoprotein(a) is the strongest hereditary risk factor for heart disease.

This statement is from lipidologists, but the American Heart Association released similar guidelines in Mar 2026 which recommend Lp(a) testing for everybody.

Only 1 in 400 people test Lp(a) today, although that's up 22x in the last decade. It's especially relevant now since four major drugs are in development that target Lp(a) specifically; one of them lowers it by 94%.

lipidjournal.com
u/brandonballinger — 2 months ago

Made a quick cheat sheet comparing how much each statin reduces cholesterol.

The above image is based on the STELLAR trial. For each statin and dose, it shows reduction in LDL cholesterol. Rosuvastatin at 40mg has the largest effect, reducing LDL cholesterol by 55% on average. Overall, there are 7 combinations of statin and dosage that will give you a 40+% reduction in LDL cholesterol.

ApoB reductions track LDL but tend to be a few points smaller.

Caveats/notes:

  • The STELLAR trial is from 2003, so it doesn't include newer drugs like ezetimibe (Zetia) or PCSK9 inhibitors. A lot of people might benefit from a statin (potentially at a lower dose) + ezetimibe, and, if you can afford it, triple therapy.
  • Nutrition (fiber, saturated fat, etc) also matters and operates through independent mechanisms, so the effects can stack.
  • These are average effect sizes, individuals do vary in their response to each drug. It's not atypical that you might need to empirically try a couple of these with your doctor, to find the one that works for your body.
  • STELLAR included 80mg doses too, but I've omitted them since they're not used as often in current medical practices.
u/brandonballinger — 2 months ago