r/PeterAttia

Rapamycin and Cerebral Blood Flow in APOE4 Carriers: An Early, Genotype-Specific Signal
▲ 12 r/PeterAttia+1 crossposts

Rapamycin and Cerebral Blood Flow in APOE4 Carriers: An Early, Genotype-Specific Signal

A review of a pilot study that seems to connect rapamycin therapy to increased cerebral blood flow in APOE4 carriers.

gethealthspan.com
u/dan_in_ca — 4 days ago

What to do ?

45 year old male. CAC score was 15 a month ago. No current heart related medications. I live a very healthy lifestyle (zero drinking, smoking, etc). 10k steps a day, lift 4x a week, and hiit 1x a week.

Given my lifestyle and overall cholesterol in range - are statins a must at this point ?

u/giannigianni1208 — 10 days ago

54 M - lab work - opinion

hi. new to this sub.
current lab work:
-----------------
54 M
Pre-Diabetic since 2022 A1C(5.8%)
current A1C (5.7%) - Metformin 1000mg Er (taken daily at night)
Diet: generally all whole food meals and very little processed foods (maybe 1-4%)
Eat red meat (maybe too much) 3x a week sometimes 4. The rest white meat and salmon 1x a week.

5'11" : 179
(working on getting to 170 which is ideal healthy weight for me)
Cardio: 5x a week (5 40 min easy runs z2 and 1 Vo2Max interval day 4x4)
Total Cholesterol: 199
HDL Cholesterol: 66
Triglycerides: 58
LDL Cholesterol: 119
Non HDL Cholesterol: 133
Apolipoprotein B: 86 (not taken in the current blood drawl- taken 4 months ago)
A1C: 5.7
Fasting Glucose: 87
urine albumin-creatinine ratio (uACR): 9

Any suggestions to drop Apolipoprotein B? Or generally ok labs.

reddit.com
u/netlifter — 11 days ago

Help Interpreting Results

37M, 5'5" 180lbs at time of the blood-work

Currently taking:

  • Tirzepatide (1.5mg, started after)
  • Creatine (5mg)
  • Pure Encapsulations Men’s Nutrients
  • Magnesium Glycinate (240mg)
  • Kirkland’s Fish Oil (1000mg)

Attached the full result in case other in-range numbers are good references but the out of range are:

  • Platelet Count: 138K/uL
  • LDL: 129mg/dL
  • Non-HDL: 152mg/dL
  • ApoB: 112mg/dL
  • RW-ApoB: 103mg/dL
  • Ferritin: 152ng/mL
  • Albumin/Creatinine Ratio, Urine: 175mg/g creat
  • T4 Free: 1.5ng/dl
  • PTFQI: 0.57
u/EducateMe24 — 10 days ago