
Rapamycin and Cerebral Blood Flow in APOE4 Carriers: An Early, Genotype-Specific Signal
A review of a pilot study that seems to connect rapamycin therapy to increased cerebral blood flow in APOE4 carriers.

A review of a pilot study that seems to connect rapamycin therapy to increased cerebral blood flow in APOE4 carriers.
45 year old male. CAC score was 15 a month ago. No current heart related medications. I live a very healthy lifestyle (zero drinking, smoking, etc). 10k steps a day, lift 4x a week, and hiit 1x a week.
Given my lifestyle and overall cholesterol in range - are statins a must at this point ?
hi. new to this sub.
current lab work:
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54 M
Pre-Diabetic since 2022 A1C(5.8%)
current A1C (5.7%) - Metformin 1000mg Er (taken daily at night)
Diet: generally all whole food meals and very little processed foods (maybe 1-4%)
Eat red meat (maybe too much) 3x a week sometimes 4. The rest white meat and salmon 1x a week.
5'11" : 179
(working on getting to 170 which is ideal healthy weight for me)
Cardio: 5x a week (5 40 min easy runs z2 and 1 Vo2Max interval day 4x4)
Total Cholesterol: 199
HDL Cholesterol: 66
Triglycerides: 58
LDL Cholesterol: 119
Non HDL Cholesterol: 133
Apolipoprotein B: 86 (not taken in the current blood drawl- taken 4 months ago)
A1C: 5.7
Fasting Glucose: 87
urine albumin-creatinine ratio (uACR): 9
Any suggestions to drop Apolipoprotein B? Or generally ok labs.
37M, 5'5" 180lbs at time of the blood-work
Currently taking:
Attached the full result in case other in-range numbers are good references but the out of range are: