Low fertilization with ICIS
We did our first IVF retrieval last month and I would appreciate opinions on what we can do or changes we can consider to our protocol for our second retrieval in a few months. We have yet to have our follow up with our doctor, and of course plan to discuss this with them when we get the chance. Apologies if my formatting isn’t great.
My partner and I are both generally healthy - normal BMI, active, no longstanding health issues other than eczema for myself (female). TTC for 1.5 years, I’ve never been pregnant or had a positive test.
- Female 32. AMH = 3.32 ng/ml, sonohysterogram normal. Prenatal, Coq10 (400mg)
- Male 33. Sperm analysis was normal, have not done a DNA fragmentation test
IVF retrieval: AFC 19, 13 eggs retrieved, 7 mature, 3/7 fertilized with ICSI, 3 made it to blast (grades 5BA, 5BA, 4BB), after PGTA testing we have 1 euploid, 2 aneuploids.
Protocol
- Rekovelle: Stim days 1-7 at 8mcg, and Stim days 8-9 at 5.33 mcg
- Menopur 75 IU: Stim days 1-3. Discontinued after this because my estrogen was 2600 on SD3.
- Orgalutran 250 mcg: Stim days 4-9
Trigger
- Decapeptyl: Stim days 9 & 10
We were shocked to have such a low fertilization rate with ICSI, and surprised that all 3 embryos made it to blast and PGTA testing! Does anything stand out in terms of what we can look into for our protocol for a 2nd retrieval or changes we should make prior to this? Any theories on why our ICSI fertilization rate was so low?