Seeking advice- thaw and fertilize all 14 eggs, or try two batches?
Hi everyone, my partner and I are navigating what to do. We have 14 frozen eggs (from two rounds of ER when I was 35/36). We are now 43 and 42. We are wondering whether to try to fertilize all at once or do two batches. His semen analysis was very good in terms of count, volume, and motility (a little low on morphology at 3%). We have not done any DNA fragmentation testing. From what I’ve read, intracytoplasmic sperm injection is standard for most clinics when using frozen eggs, so I’m not so worried about morphology. I’m scared of something going wrong with the thaw and culture process, thus wanting an insurance plan of having held back half. I read a difficult post about embryos being contaminated because of an undiagnosed prostrate infection. But on the other hand, I think I expect to get 2-3 viable embryos, so maybe it’s better to just go for it. Notably, I froze the eggs to preserve fertility and I now have very low AMH, but I don’t have a specific reason to suspect poor egg quality or unexplained infertility. So let’s call them normal 35 year old eggs, as far as we know. Do you think we should test for sperm DNA fragmentation first, since this is likely our only shot? We are also trying to decide whether to do one fresh transfer or freeze all to be able to test for aneuploidy. One of the doctors we spoke with recommended PGT while the other didn’t think it was a high priority for age 35 eggs and instead thought a fresh transfer would improve odds a bit over frozen. Any advice or experience would be appreciated!
