u/gagan6696

Hi everyone,
I’m looking for some insights or similar experiences. We (M30/F31) just finished our first IVF cycle after 4 years of unexplained infertility, and the results were devastating.
**The Background:**
• **AMH:** 4.58
• **Scan:** 13 follicles seen during stims.
• **Retrieval:** Only 3 eggs retrieved (rest were empty).
• **Fertilization:** 3 eggs retrieved -> 2 fertilized via ICSI.
• **Grading at Day 3:** One Grade B and one Grade C (with significant fragmentation).
• **Outcome:** Both embryos arrested at Day 3. Zero growth by Day 5/6.
**Specific Issues Noticed:**

1. **Trigger Response:** In previous IUI/Timed cycles, follicles would often rupture late (after 36-40 hours). This time we did a standard 36-hour retrieval, and I suspect the "Empty Follicles" might have been due to eggs being immature or not detaching in time.
2. **Day 3 Arrest:** Since both stopped right at the Day 3 mark, we are wondering if this points towards a specific DNA issue or Sperm DNA Fragmentation (DFI), as I understand the embryonic genome kicks in then.
   **My Questions:**
3. Has anyone dealt with a high follicle count but very low egg yield? Did a **Dual Trigger** (hCG + Lupron) help in the next cycle?
4. Does Day 3 arrest always mean poor egg quality, or should we look into **Sperm DNA Fragmentation (DFI)** testing?
5. What supplements or protocol changes (like adding Growth Hormone/Omnitrope or CoQ10) worked for you in improving blastocyst conversion?
   We are heartbroken but planning for a 2nd round. Any advice on what to ask our RE during the regroup meeting would be highly appreciated

Hi everyone,
I’m looking for some insights or similar experiences. We (M30/F31) just finished our first IVF cycle after 4 years of unexplained infertility, and the results were devastating.
The Background:
• AMH: 4.58
• Scan: 13 follicles seen during stims.
• Retrieval: Only 3 eggs retrieved (rest were empty).
• Fertilization: 3 eggs retrieved -> 2 fertilized via ICSI.
• Grading at Day 3: One Grade B and one Grade C (with significant fragmentation).
• Outcome: Both embryos arrested at Day 3. Zero growth by Day 5/6.
Specific Issues Noticed:

1. Trigger Response: In previous IUI/Timed cycles, follicles would often rupture late (after 36-40 hours). This time we did a standard 36-hour retrieval, and I suspect the "Empty Follicles" might have been due to eggs being immature or not detaching in time.
2. Day 3 Arrest: Since both stopped right at the Day 3 mark, we are wondering if this points towards a specific DNA issue or Sperm DNA Fragmentation (DFI), as I understand the embryonic genome kicks in then.
   My Questions:
3. Has anyone dealt with a high follicle count but very low egg yield? Did a Dual Trigger (hCG + Lupron) help in the next cycle?
4. Does Day 3 arrest always mean poor egg quality, or should we look into Sperm DNA Fragmentation (DFI) testing?
5. What supplements or protocol changes (like adding Growth Hormone/Omnitrope or CoQ10) worked for you in improving blastocyst conversion?
   We are heartbroken but planning for a 2nd round. Any advice on what to ask our RE during the regroup meeting would be highly appreciated