Got these back recently. Positive skin biopsy, waiting on an EMG but have had no motor issues, only sensory. My neuro told me today that I'm the first patient she's ever had test positive for this antibody
Posted here a few days ago that I got a positive skin biopsy result. My neurologist thinks it was COVID induced, I had an initial onset in Sept 2024 (1 month after getting COVID), that lasted for a few weeks and then symptoms subsided. I had more mild flares off and on until March 2025. After March 2025, I didn't have a single symptom and was feeling great, until I got a mild cold in December 2025. 2 weeks later, the nerve pin pricking pain and itching, as well as burning returned, but only for a couple days at a time. Certain things would trigger it like going to the gym, so I decided to stop for awhile. Since then, I've had 2 longer flares in March and currently in another one right now.
Has anyone ever had 9+ months of remission? My confusion and question is, since my biopsy is positive, did my nerves heal that quickly and the December 2025 virus damaged them again? Can't seem to find anyone else in a similar situation as me. Any advice on if you improved or what you did to recover from post covid SFN would be greatly appreciated.
Im 26, started having SFN symptoms back in 2024 a month after a Covid infection. They only lasted about a month, and I had very few minor flare ups in 2025, until I got sick this past December. Since then, I've had multiple flare ups lasting weeks, and then relief where I feel symptom free for weeks. I have no other LC symptoms, but I did have parosmia for 6 months in 2021 after getting one of the first strains, followed by another 6 months of the most insane intense anxiety I've ever experienced in my life, and insomnia. Felt like I was going crazy but those have resolved for the most part.
This prompted my neurologist to suspect SFN from COVID and ordered a skin punch biopsy, with both samples coming back with significant loss of intraepidermal nerves (< 5/ linear mm in both my foot and leg). I have it all over the place though.
Has anyone here actually gotten a positive SFN result with seemingly every other autoimmune result ruled out? And if so, did it get better?
Hi, I'm a 26M, healthy overall, and just today receive a positive skin punch biopsy diagnosis. It's all over my body, and it comes in flares. It first started in October 2024 after having COVID, about a month later. I had no clue what it was, doctors had no ideas so they sent me for a brain MRI to rule anything out. It lasted for about a month badly, then went away and came back in flares for a few more weeks. Then for most of 2025, it was completely gone. Fast forward to Dec 2025, I got sick again, and then in January the itching / pricking and burning came back. It went away, but then I started going to gym and working out about a month ago and it came back full force, just as bad as the first time around that I had this.
My neurologist suggested it could be SFN from COVID so sent me for a skin punch biopsy, and surprisingly came back positive at both sites. According to the report, "showed significant loss, (with < 5/linear mm in both) of intraepidermal nerve fibers).
Even these past few weeks, it'll completely go away and then come back. I've been tested for pretty much everything that can cause it, diabetes, autoimmune diseases, all negative. I haven't had MCAS ruled out so I've been looking into that. Has anyone else experienced the same thing as me and had a positive biopsy, but ended up fully recovering? Any insight is very appreciated, thank you. I'm really nervous about this diagnosis and can't stop worrying if I'm gonna have this for the rest of my life.