u/djroge

Hey all, my(27M) gf(24F) just started Alyftrek yesterday. Her doctors told her to start with half doses because she's had complications with modulators before. As the title suggests she's already coughing up blood before even the 24 hour mark of her taking the first half dose.

She's actually really healthy. She goes to the gym with me, she trains jiu jitsu, she and her sister (also has CF) run long distance together. For whatever reason when she tries modulators (Trikafta and Alyftrek) they always cause her to cough up blood and feel awful.

Is her body rejecting the modulators? Has anyone else experienced something similar? If anyone has any advice it would be greatly appreciated. TIA!

Edit: this probably helps. She is delta f508 homozygous.