Study: Zoloft/Sertraline may affect vitamin B1 transport
I found an interesting paper about medication/nutrient interactions and wanted to share it in simple terms.
The study looked at thiamine, also known as vitamin B1, and a transporter called ThTR-2 / SLC19A3. This transporter helps the body absorb/move B1.
The researchers tested many prescription drugs and found that some could inhibit this B1 transporter. Sertraline/Zoloft was one of the drugs listed as potentially relevant.
This does not mean Zoloft automatically causes B1 deficiency. The study is more about a possible mechanism, especially in people who may already be vulnerable to low B1, like those with poor nutrition, alcoholism, malnutrition, or certain health conditions.
I thought it was worth sharing because low B1 can cause symptoms like fatigue, brain fog, weakness, nerve problems, and mood changes and symptoms that can overlap with what some people experience for many different reasons.
Not medical advice, and definitely not saying anyone should stop Zoloft. But if someone is on sertraline long-term and has risk factors or unexplained symptoms, maybe it’s worth asking a doctor about thiamine/B1.
Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC6944527/