Unexplained infertility - we've had so many tests done, but still no answers
My husband and I have been trying to conceive for a little more than a year and a half, and so far, all of our test results have been normal.
Here’s what we’ve done so far:
- My vaginal/cervical swabs (Mycoplasma, Ureaplasma, Chlamydia) - negative
- Semen analysis and sperm culture - normal
- Pap smear and colposcopy - normal
- Ovulation confirmed for the past 7-8+ months
- HSG - normal, tubes are open
- I also tried ovulation stimulation with Clomid
- Hormone levels - normal
- Regular 28-day cycles, no PCOS
- AMH - normal
- Antisperm antibodies - normal
- I was also tested for both inherited and acquired thrombophilias. The only findings were PAI-1 5G/5G, Factor XIII, and MTHFR C677T.
The only thing that might be a minor issue is mild hyperinsulinemia. However, my endocrinologist didn’t consider it significant enough to require treatment, while my gynecologist prescribed Glucophage XR 1000 mg anyway, just to rule out insulin resistance as a contributing factor. I’ve been taking it for several months now.
At this point, we have been diagnosed with unexplained infertility.
We also recently had our first IUI. I’m currently 14 DPO, and I’m supposed to have my beta hCG blood test in the next few days. But I did two PT on my own on 11 and 13 DPO and both were negative, so I'm not expecting a miracle.
However, regardless of the outcome of this cycle, I’m wondering what else we should investigate. I feel like we’ve already done so many tests, but I’m still not sure if there’s something important we might be missing.
For those of you who have been through something similar, what additional tests did you have done? Did you ever find a cause for your infertility?
I would really appreciate hearing about your experiences and what you would recommend looking into next. Thank you in advance! ❤️