r/whatworkedforme

My husband and I have been trying to conceive for a little more than a year and a half, and so far, all of our test results have been normal.

Here’s what we’ve done so far:

1. My vaginal/cervical swabs (Mycoplasma, Ureaplasma, Chlamydia) - negative
2. Semen analysis and sperm culture - normal
3. Pap smear and colposcopy - normal
4. Ovulation confirmed for the past 7-8+ months
5. HSG - normal, tubes are open
6. I also tried ovulation stimulation with Clomid
7. Hormone levels - normal
8. Regular 28-day cycles, no PCOS
9. AMH - normal
10. Antisperm antibodies - normal
11. I was also tested for both inherited and acquired thrombophilias. The only findings were PAI-1 5G/5G, Factor XIII, and MTHFR C677T.

The only thing that might be a minor issue is mild hyperinsulinemia. However, my endocrinologist didn’t consider it significant enough to require treatment, while my gynecologist prescribed Glucophage XR 1000 mg anyway, just to rule out insulin resistance as a contributing factor. I’ve been taking it for several months now.

At this point, we have been diagnosed with unexplained infertility.

We also recently had our first IUI. I’m currently 14 DPO, and I’m supposed to have my beta hCG blood test in the next few days. But I did two PT on my own on 11 and 13 DPO and both were negative, so I'm not expecting a miracle.

However, regardless of the outcome of this cycle, I’m wondering what else we should investigate. I feel like we’ve already done so many tests, but I’m still not sure if there’s something important we might be missing.

For those of you who have been through something similar, what additional tests did you have done? Did you ever find a cause for your infertility?

I would really appreciate hearing about your experiences and what you would recommend looking into next. Thank you in advance! ❤️

Hi everyone,

I’m 31 and have been trying to conceive for 22 cycles. I always thought I would get pregnant very easily because every woman in my family got pregnant effortlessly without even trying.

After 6 months, I started feeling anxious, so I visited my gynecologist. We ran basic tests like hormone panels, AMH, a semen analysis, and everything looked normal on paper. We tried cycles with Letrozole and trigger shots, but still nothing happened.

Next, I had an HSG (hysterosalpingogram) test, which came back normal.

After a year, I was super stressed and felt like it would never happen. Around my 17th and 18th cycles, I had two IUIs, both of which resulted in negative tests.

I then pushed my doctor for an endometrial biopsy, which came back positive for endometritis, though it was a minimal infection up to 2/10. I was told this was insignificant, but I wanted to take antibiotics anyway.

Later, I showed my HSG report and X-ray to a second doctor for a second opinion. She asked if I had any more images, but only one picture had been taken. She mentioned that even though the contrast fluid passed through the uterus and tubes, it looked like there might be adhesions at the ends of the tubes. However, they said we had no choice but to trust the radiologist, and added, "You should just start IVF because if it were going to happen naturally, it would have happened by now."

So, last month, we decided to start IVF. I began injections, and yesterday was my last shot. I have 10 mature follicles, and my egg retrieval is scheduled for tomorrow. I am looking for positive stories similar to mine because I currently feel hopeless and negative.

Has anyone had recurrent chemical pregnancies, lost weight then had a successful pregnancy? I’ve had 3 chemical pregnancies with a successful pregnancy after my first CP. My doctor believes it may be my weight causing this. I’m 34 years old, 5’8, 255 lbs and I have high triglycerides and low hdl. I also have TPO antibodies but my thyroid numbers are normal. But no other health issues that I know of (we’re going to do a recurrent pregnancy panel still).

My husband was recently diagnosed with secondary MFI due to severe oligospermia, with 3 mil concentration, 30% motility, and 3% morphology. We conceived our first child about 5 years ago and his numbers were better then—closer to 23 mil concentration. He has already implemented all the recommended lifestyle changes for more than a year and now we are looking into vitamins and supplements to hopefully boost his numbers a bit which from what I understand can take 3 months to have an effect.

We have been referred to specialists in hopes of getting prescribed HCG but would like to keep trying on our own in the meantime. For anyone whose partner has MFI what you did you do to conceive?

I wanted to share my TTC story because I spent so much time reading other women’s stories when we were trying.
**Quick disclaimer:** this is just what I personally did. I’m not saying this combination caused my pregnancies or that anyone else should copy it. Please check with your doctor before taking supplements.
My husband and I tried for about **8-9 months** without getting pregnant.
I have **prediabetes and symptoms of insulin resistance**, although my doctor told me I do **not** have PCOS. I wasn’t really changing my diet much at the time. We were just trying every month and living normally.
After several months, I started getting discouraged and eventually came across a TikTok from a woman sharing what she had used while TTC.
I did my own research and started taking:

**Myo-inositol**
**Maca** containing red and black maca
**Fish oil — 1,000 mg daily**
**NAC — 600 mg daily**
**Vitamin D3**
**Prenatal vitamin**
**CoQ10 — 600 mg daily**
**Baby aspirin — morning and night**
**Mucinex about 30 minutes before baby dancing during my fertile window**
**I did seed cycling taking seeds like sunflower seeds Brazilian nuts, flax seeds and pumpkin seeds.**
**I did a low carb diet. Basically ate foods that didn’t heavily spike my blood sugar.**
**I prayed hard.**

My husband also took a **men’s fertility/multivitamin supplement** intended to support sperm and semen health.
About **30 days after starting this routine, I got pregnant.**
Unfortunately, I miscarried very early, at around **5–6 weeks**.
I wondered whether my blood sugar, diet, or insulin resistance had anything to do with it, but I’ll never really know. Early miscarriages can happen for many reasons.
What happened next surprised me.
**I never got a period after the miscarriage.( I continued the routine above I never stopped )**
We continued trying, I apparently ovulated before my period returned, and **I got pregnant again immediately.**
That second pregnancy became my son. ❤️
Because I already had prediabetes and insulin-resistance symptoms, I became much more serious about my blood sugar during that pregnancy. I monitored it carefully and managed it through **diet alone for the entire pregnancy**. I maintained an A12 of 4.9-5.2 the entire time.
My faith was also a huge part of this journey.
I prayed while we were trying, through the negative tests, through my first pregnancy, through the miscarriage, and throughout my second pregnancy.
**June Of 2026 we had our baby boy**
I don’t know exactly what changed for us.
Maybe some of the supplements helped. Maybe timing played a role. Maybe addressing things related to my insulin resistance helped. Maybe we simply finally reached the month when it was going to happen.
I mainly wanted to share this for another woman who might be searching Reddit the same way I was.
**Feel free to ask any question I will be replying.**

Hello all,

I started testing with home pregnancy tests on day 6 post transfer, today is day 8 post transfer. It was a 5-day blastocyst rated 4BB, made from an egg frozen 4 years ago.

The home pregnancy test today was negative. The beta test is tomorrow. Is there still any hope?

Hello!

I guess I’m coming here to see if anyone has been through this and is somehow managing to come to terms with things better than I can.

Every month, I find myself crying and mourning the life that I long for.

I have a wonderful husband and a beautiful son who is 6 but, I desperately would love another baby.

I’m so so very grateful for what I have but it hasn’t been easy for me getting here. It took us 3 years to conceive our son and, I was extremely poorly during pregnancy and birth and near organ failure, being rushed in to have my son as a matter of emergency.

Since having our son, we have tried many a time for another baby. My son often asks if he will have a bother or sister.

I have suspected endometriosis as well a fibroids ( growths in the womb) so fertility has been a delicate subject. My husband was tested and he’s got healthy swimmers so, it’s just my body causing issue.

Each month has been so hard, every time a period comes, I feel like I’m mourning the loss of a baby that never happened. This has massively impacted my mental health and as much as my husband and I would love a baby, we decided to put a stop on trying.

Recently I came off some medication which was for
My fibroids. Since coming off this medication my hormones have come back thick and fast, as have my monthlies. I guess this has made my body feel that a baby is now possible again and has bought back all the feelings of yearning for that baby again.

I asked my husband if we should open that capture again and he has explained that he has come to terms with it all and that he doesn’t think it’s a good idea.

It’s so tough, I have no control over my body but I feel responsible for it not behaving as it should. I am 35 and although that’s not old, it’s not young either. I do feel that, the closer I get to menopause the more I’m going to have to accept that it’s over but I’m really struggling to let go of this chapter. I’ve always got hope that it’s not over and it will happen again for me.

Has anyone been through this feeling themselves? Everyone I know has had no issue in conceiving and people make it look so easy. I don’t know what I’m hoofing for in posting this but I don’t really have anyone I can talk to.

Sorry for the essay.

Hey everyone, I just really need to vent and hopefully get some insight from people who actually get it.
TTC has been such a heavy, exhausting journey. Back in July 2024, I got pregnant using Letrozole, but unfortunately lost the baby shortly after (we still don't know why). After taking time to heal, I started trying again and switched OBGYNs. Last November (2025), my new doctor discovered I have endometriosis. It hasn't been officially staged, and I haven't had surgery for it yet.
Since the diagnosis, I feel like I've tried everything to tackle this head-on:
Endo suppression: Did a course of Norethindrone + Letrozole.
Weight loss: Completed 2 rounds of GLP-1 medication.
Optimized labs: Brought up and stabilized my Vitamin D3, B12, and Iron levels.

We got back to active TTC two months ago and just had our first IUI fail. It’s devastating.
I’m so frustrated. Watching literally everyone around me get pregnant—and so easily—is getting harder to swallow every day. It feels so unfair.

For those who have been through endo + secondary/unexplained infertility:
Would excision surgery (laparoscopy) make a difference at this point? Did finding/removing endo help you conceive naturally or through IUI?
Should we skip more IUIs and jump straight to IVF?
What else can be done differently? (Protocols, testing, RE consults, etc.?)
I’d love to hear your experiences, advice, or even just some reassurance. Thank you so much for reading. ❤️