Has anyone had BCR-ABL plateau after multiple TKIs? What happened next?
Hi everyone,
I'm posting on behalf of my boyfriend (31M), who has chronic-phase CML.
He has been through multiple TKIs, including ponatinib, and is now on asciminib. His blood counts have improved, but his BCR-ABL PCR has remained persistently elevated. Following his most recent PCR, his asciminib dose was increased. Although there has been some reduction, it has been very slow, and his hematologist has started discussing the possibility of an allogeneic stem cell transplant if his response doesn't improve.
I know everyone's journey is different, and I'm not looking for medical advice or predictions.
I'm hoping to hear from anyone who has experienced something similar:
* Did your BCR-ABL plateau at a high level for a while?
* Did switching dosage eventually help?
* Did you go on to a stem cell transplant even when CML in chronic phase?
* How did you and your partner cope emotionally during that period of uncertainty?
Most stories I find are from people whose PCR drops quickly, so it's been hard to find experiences that resemble ours.
Thank you to anyone willing to share.