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youtu.beFrontiers | Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report
Case presentation:
We report the case of an octogenarian Japanese-American woman with a 10-year history of Alzheimer’s disease, including 5 years of marked hypofunction and predominantly monosyllabic speech. Baseline features included chronic urinary incontinence, executive dysfunction, dysphagia, dependent mobility, flat affect, and severe reduction in spontaneous communication. The patient received 5 g of orally administered psilocybin-containing mushrooms (Enigma strain). The acute phase was marked by autonomic activation, clinically suspected hyperthermia, profuse sweating, and a prolonged deep sleep-like state. Approximately 19 h post-administration, spontaneous autobiographical speech emerged. Over subsequent days and weeks, functional improvements included restoration of urinary continence, improved ambulation, autonomous dressing, increased emotional responsiveness, sustained social interaction, contextual memory retrieval, preserved working memory for social context, and spontaneous conversational engagement.
Psychedelic Medicines and Mental Health: Emerging Science and Policy Opportunities
Please join us for a Capitol Hill briefing examining how psychedelic medicines could help address some of America's most urgent mental health challenges, including depression and PTSD.
The program will feature remarks from Rep. Jack Bergman (MI-01), followed by a panel discussion. Drawing on perspectives as veterans, clinicians, patient advocates, and policy experts, panelists will discuss the economic toll of America's mental health crisis; the unmet need for new treatment options; the science behind psychedelic medicines; and how policymakers and regulators can support rigorous review and responsible access to promising treatments.
Speakers:
- Moderator: Peter Pitts, former FDA associate commissioner; president, Center for Medicine in the Public Interest
- Ryan Schloesser, lieutenant colonel (retired), U.S. Army, VALOR
- Vanessa Joy Walker, M.P.H., policy advisor, Depression and Bipolar Support Alliance
- Dimitrios Cavathas, L.C.S.W.-C., chief executive officer, HealthPort
- Steve Levine, M.D., chief patient officer, Compass Pathways