u/loopofhenlee

▲ 6 r/MTHFR

Daughter prescribed 15mg methylfolate

Hello,

My daughter (8 yr) has had difficulty with emotional regulation, sensory processing, executive functioning, mood swings, and adhd symptoms for years now. We’ve been through the gambit of occupational therapy, psychologists, and more recently psychiatrists. One of the psychiatrists had her get a metabolic genetic panel done in order to get a better idea about medication dosing, and we found a homozygous c/c 1298 MTHFR variant. She has a Val/Met type for COMT.

Anyway, we’ve been trying all sorts of things because while she is a wonderful and lovable girl, she also started running away, hitting people, throwing things, and yelling at everyone. I could go into much more detail but things were getting very very bad. The Dr wanted to address her MTHFR variant and said the dose recommendation is 7.5-15mg. We started her on 7.5mg and saw an improvement with everything. So Dr said ok try the next dose up, 15mg.

Only now did I stumble upon this group and now seeing that 15mg is an incredibly high dose. The capsule also has 1,000mcg Vit B12. I called to ask if this was safe and they essentially said it’s fine as long as she isn’t showing side effects.

I don’t think we’re seeing negative effects, but lately she’s been taking longer to fall asleep. I would greatly appreciate any guidance or thoughts you may have on this!

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u/loopofhenlee — 3 days ago