u/lumagre

I’ve been doing IV ketamine treatment for depression for a little over a year.

At first, it worked extremely well. The treatment was genuinely life-changing for me. But over the past several months, the infusions seem to have lost almost all of their therapeutic effect.

I tried increasing the dose, but that ended up causing far more negative effects than positive ones. It got bad enough that I had to stop treatment for a few months, and I really do not want to end up in that situation again.

During the infusions, I already try to reduce sensory input as much as possible. I use a well-sealed sleep mask to block out light and headphones to isolate sound. That has helped a lot, and I do think the setting makes a meaningful difference for me.

Now I’m trying to figure out whether there are any supplements, strategies, or other adjustments that might help me get more therapeutic benefit from ketamine again, without simply pushing the dose higher.

I’ve heard some people mention magnesium L-threonate for this purpose. Has anyone here tried it specifically to improve or restore the effects of ketamine treatment? Did it make any noticeable difference?

I’d also be interested in hearing about anything else that helped you after ketamine infusions started becoming less effective over time.

Thanks in advance.

I’ve been doing IV ketamine treatment for depression for a little over a year.

At first, it worked extremely well. The treatment was genuinely life-changing for me. But over the past several months, the infusions seem to have lost almost all of their therapeutic effect.

I tried increasing the dose, but that ended up causing far more negative effects than positive ones. It got bad enough that I had to stop treatment for a few months, and I really do not want to end up in that situation again.

During the infusions, I already try to reduce sensory input as much as possible. I use a well-sealed sleep mask to block out light and headphones to isolate sound. That has helped a lot, and I do think the setting makes a meaningful difference for me.

Now I’m trying to figure out whether there are any supplements, strategies, or other adjustments that might help me get more therapeutic benefit from ketamine again, without simply pushing the dose higher.

I’ve heard some people mention magnesium L-threonate for this purpose. Has anyone here tried it specifically to improve or restore the effects of ketamine treatment? Did it make any noticeable difference?

I’d also be interested in hearing about anything else that helped you after ketamine infusions started becoming less effective over time.

Thanks in advance.